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anti-Cow (Bovine) GRB2 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended GRB2 Antibody (supplied by: Log in to see )

Antigen
Growth Factor Receptor-Bound Protein 2 (GRB2) Antibodies
  • GRB2
  • grb2
  • AA408164
  • Ash
  • ASH
  • EGFRBP-GRB2
  • Grb3-3
  • MST084
  • MSTP084
  • NCKAP2
  • wu:fb18e12
  • wu:fb34e06
  • zgc:73077
  • growth factor receptor-bound protein 2
  • Growth factor receptor-bound protein 2
  • growth factor receptor bound protein 2
  • growth factor receptor-bound protein 2b
  • GRB2
  • grb2
  • Grb2
  • LOC100342500
  • grb2b
Epitope
AA 198-217, C-Term
33
18
16
6
6
6
6
5
5
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
158
64
64
16
10
9
7
5
5
4
3
3
3
3
3
2
2
1
1
Host
Rabbit
104
28
25
2
Clonality
Polyclonal
Conjugate
This GRB2 antibody is un-conjugated
8
4
3
3
3
3
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
141
69
55
31
13
7
5
4
2
2
2
1
Supplier
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Catalog No. ABIN615588
$ 500.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
12.795739 ABIN364459 IHC (p) WB Mouse IgG1, kappa Log in to see
1 ABIN374150 EIA IHC (p) WB Goat C-Term Log in to see Polyclonal 1
1 ABIN180592 IF IHC (p) Mouse IgG1 Log in to see 2GB04-same C1-4
1 ABIN481756 IHC (p) ELISA WB Goat AA 206-217 Log in to see Polyclonal
1 ABIN2450618 IF IHC (p) Mouse IgG1, kappa AA 54-62 Log in to see 2GB04
1 ABIN384842 IF IHC (p) Mouse IgG1, kappa AA 54-62 Log in to see 2GB04
1 ABIN1735236 IHC (p) ELISA WB Goat C-Term Log in to see Polyclonal
1 ABIN208556 IHC (fro) IF IHC (p) WB Mouse IgG1, kappa AA 54-62 Log in to see

Top referenced anti-GRB2 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Similar anti-GRB2 Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus) Cow (Bovine)
Immunofluorescence (fixed cells) (IF/ICC) 2 Antibodies 1 Antibodies 1 Antibodies
Western Blotting (WB) 141 Antibodies 57 Antibodies 57 Antibodies 14 Antibodies
Immunoprecipitation (IP) 7 Antibodies 2 Antibodies 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 32 Antibodies 9 Antibodies 14 Antibodies 14 Antibodies
Immunohistochemistry (IHC) 55 Antibodies 14 Antibodies 13 Antibodies 1 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 2 Antibodies 1 Antibodies

General

Antigen Growth Factor Receptor-Bound Protein 2 (GRB2) Antibodies
Epitope AA 198-217, C-Term
(33), (18), (16), (6), (6), (6), (6), (5), (5), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
(158), (64), (64), (16), (10), (9), (7), (5), (5), (4), (3), (3), (3), (3), (3), (2), (2), (1), (1)
Host Rabbit
(104), (28), (25), (2)
Clonality
Polyclonal
Conjugate This GRB2 antibody is un-conjugated
(8), (4), (3), (3), (3), (3)
Application Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(141), (69), (55), (31), (13), (7), (5), (4), (2), (2), (2), (1)
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Product Details anti-GRB2 Antibody

Target Details GRB2 Application Details Handling Images
Specificity The polyclonal antibody recognizes Grb2, a highly conserved approximately 26 kDa adaptor protein.
Purification Immunoaffinity Chromatography
Immunogen GRB2 antibody was raised against synthetic peptide corresponding to C-terminus of human Grb2 (amino acids 198-217). .Remarks: 100% identity between man, cow, rat and mouse

Target Details GRB2

Product Details anti-GRB2 Antibody Application Details Handling Images back to top
Antigen
Alternative Name GRB2 / ASH (GRB2 Antibody Abstract)
Background Growth factor receptor bound protein 2 (GRB2), also known as Ash protein, is a 24 kDa protein that contains a central Src homology (SH2) domain flanked by two SH3 domains. GRB2 is believed to be a regulatory subunit of signaling molecules whose activity is modulated by receptor binding. GRB2 associates with activated (tyrosine phosphorylated) EGFR and PDGFR via its SH2 domain as well as IRS1, SHC, and LNK through SH2 and SH3 domains. The SH3 domain binds to SOS, a guanine nucleotide exchange factor for Ras proteins. Endocytosis of activated EGFR requires the interaction of GRB2 with the GTP binding protein dynamin, a factor essential to the formation of endocytotic vesicle. It is ubiquitously expressed and several isoforms are produced by alternative splicing. On SDS PAGE, GRB2 has an apparent molecular weight of 28 kDa.Synonyms: Growth factor receptor-bound protein 2
Gene ID 2885
NCBI Accession NP_002077
UniProt P62993
Research Area Signaling
Pathways RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, EGFR Downregulation

Application Details

Product Details anti-GRB2 Antibody Target Details GRB2 Handling Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-GRB2 Antibody Target Details GRB2 Application Details Images back to top
Buffer PBS containing 15 mM sodium azide and 0.2 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Images

Product Details anti-GRB2 Antibody Target Details GRB2 Application Details Handling back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-GRB2 antibody (Growth Factor Receptor-Bound Protein 2) (AA 198-217) (ABIN615588) IHC Image for AP23211PU-N Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-GRB2 antibody (Growth Factor Receptor-Bound Protein 2) (AA 198-217) (ABIN615588) IHC Image for AP23211PU-N Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-GRB2 antibody (Growth Factor Receptor-Bound Protein 2) (AA 198-217) (ABIN615588) IHC Image for AP23211PU-N Human Colon, Myenteric Plexus: Formalin-Fixed, Paraffin-Emb...