V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Antibodies
Cow (Bovine), Gibbon, Gorilla, Hamster, Horse (Equine), Human, Monkey, Mouse (Murine), Rat (Rattus)
This HER2 antibody is un-conjugated
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BLAST analysis of the peptide immunogen showed no homology with other human proteins.
ERBB2 antibody was raised against a peptide located in the cytoplasmic domain of ERBB2 (Human).
ERBB2 Antibody Abstract)
A tyrosine kinase receptor in the EGF-receptor family. ErbB2 does not bind ligand on its own, but acts as an amplifier in heterodimers with ErbB1, (EGFR), ErbB3, or ErbB4. Amplification of the ErbB2 gene and overexpression of ErbB2 protein is associated with breast cancer (~25â€¯% of cases), and anti-ErbB2 therapeutics (e.g. Herceptin, an anti-ErbB2 monoclonal antibody) are sometimes effective in treating these cases. Overexpression of ErbB2 has also been indicated as a factor in prostate cancer.
RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
ERBB2 antibody can be used in ELISA starting at 1:10000, Western Blot starting at 1:500 - 1:2000, immunohistochemistry starting at 1:200, and immunofluorescence starting at 1:200 - 1:1000.
For Research Use only
PBS, 0.1 % sodium azide.
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
As with all antibodies avoid freeze/thaw cycles.
4 °C/-80 °C
ERBB2 antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.
anti-V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) (Cytoplasmic Domain) antibody