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|Application / Reactivity||Human|
|Cellular Assay (CA)||1 Antibodies|
|Cytometry by Time of Flight (CyTOF)||14 Antibodies|
|Dot Blot (DB)||192 Antibodies|
|ELISA (Capture)||3 Antibodies|
|Enzyme Immunoassay (EIA)||17 Antibodies|
|Flow Cytometry (FACS)||285 Antibodies|
|Functional Studies (Func)||5 Antibodies|
|Immunoassay (IA)||1 Antibodies|
|Immunochromatography (IC)||5 Antibodies|
|Immunocytochemistry (ICC)||87 Antibodies|
|Immunoelectron Microscopy (IEM)||6 Antibodies|
|Immunofluorescence (IF)||299 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||102 Antibodies|
|Immunohistochemistry (IHC)||335 Antibodies|
|Immunohistochemistry (Acetone-fixed) (IHC (af))||5 Antibodies|
|Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))||2 Antibodies|
|Immunohistochemistry (Formalin-fixed Sections) (IHC (f))||3 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||107 Antibodies|
|Antigen||V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Antibodies|
|Conjugate||This HER2 antibody is un-conjugated Alternatives|
Immunohistochemistry (Acetone-fixed) (IHC (af)), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)), Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
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Product Details anti-HER2 AntibodyTarget Details HER2 Application Details Handling Images
This antibody recognises epitope E of human HER2/neu, otherwise known as CD340 and c-ErbB-2, a proto-oncogene expressed at the cell surface of a range of tumour cells, which is often associated with poor prognosis, and an increased risk of metastasis.
HER2/neu is used in conjunction with antibodies recognising both Estrogen and Progesterone receptors, for the classification of breast cancer tumours, and to determine patient prognosis and course of treatment.
Excessive HER2/neu is present in around 20 % to 25 % of invasive breast cancers, referred to as HER2-positive cancer, and can help determine whether drugs such as trastuzumab (Herceptin) or lapatinib (Tykerb), might be beneficial.
Rat Anti Human Cd340
Protein Size: 1225
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
Target Details HER2Product Details anti-HER2 Antibody Application Details Handling Images back to top
|Alternative Name||ERBB2 (ERBB2 Antibody Abstract)|
|Background||Rat Anti Human Cd340|
|Pathways||RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-HER2 Antibody Target Details HER2 Handling Images back to top
|Application Notes||Flow Cytometry: Use 10 μL of the suggested working dilution to label 1x106 cells in 100 μL.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-HER2 Antibody Target Details HER2 Application Details Images back to top
|Handling Advice||Avoid repeat freeze-thaw cycles.|
|Storage||4 °C,-20 °C|
Store at +4 °C or at -20 °C if preferred.
This product should be stored undiluted.
Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.