anti-Mouse (Murine) HER2 antibody for Dot Blot

Recommended HER2 Antibody (supplied by: Log in to see )

Antigen
V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Antibodies
  • CD340
  • HER-2
  • HER-2/neu
  • HER2
  • MLN 19
  • NEU
  • NGL
  • TKR1
  • Erbb-2
  • Neu
  • c-erbB2
  • c-neu
  • mKIAA3023
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
  • v-erb-b2 avian erythroblastic leukemia viral oncogene 2
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • ERBB2
  • Erbb2
Epitope
pSer1114
101
95
72
69
62
55
55
48
46
35
26
22
22
21
20
20
20
20
20
20
20
20
19
19
19
19
18
17
15
15
13
13
13
12
11
8
8
8
8
8
7
7
6
6
5
5
4
4
4
4
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine)
1374
493
325
36
34
15
13
8
6
5
4
3
3
3
2
1
1
1
1
1
Host
Rabbit
1005
512
30
16
12
5
1
Clonality
Polyclonal
Conjugate
This HER2 antibody is un-conjugated
76
66
59
54
46
41
19
19
12
12
11
10
10
9
8
8
8
8
8
7
7
7
7
7
7
7
7
6
3
2
2
Application
Dot Blot (DB)
716
602
318
314
309
308
267
132
112
102
89
21
19
18
8
6
6
5
3
3
3
2
1
1
1
1
1
1
1
Options
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Catalog No. ABIN1881311
$ 324.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
28.577646 ABIN1881306 DB Rabbit pSer1051 Log in to see Polyclonal 5
28.577646 ABIN1539719 DB Rabbit Ig pSer999 Log in to see Polyclonal
28.577646 ABIN1539787 DB Rabbit Ig pTyr1223 Log in to see Polyclonal
28.577646 ABIN1539699 DB Rabbit Ig pSer26 Log in to see Polyclonal
28.577646 ABIN3029496 DB ELISA Rabbit Ig Fraction pSer1114 Log in to see Polyclonal
28.577646 ABIN3029507 DB ELISA Rabbit Ig Fraction pTyr1223 Log in to see Polyclonal
28.577646 ABIN3029513 DB ELISA Rabbit Ig Fraction pSer999 Log in to see Polyclonal
28.577646 ABIN3029495 DB ELISA Rabbit Ig Fraction pSer1051 Log in to see Polyclonal
28.577646 ABIN3029503 DB ELISA Rabbit Ig Fraction pTyr1197 Log in to see Polyclonal
28.577646 ABIN3029502 DB ELISA WB Rabbit Ig Fraction pTyr1140 Log in to see Polyclonal
1 ABIN1967262 DB ELISA Alkaline Phosphatase (AP) Rabbit IgG pTyr1197 Log in to see Polyclonal
1 ABIN1967261 DB ELISA Alkaline Phosphatase (AP) Rabbit IgG pTyr1140 Log in to see Polyclonal
1 ABIN1967263 DB ELISA Alkaline Phosphatase (AP) Rabbit IgG pTyr1223 Log in to see Polyclonal
1 ABIN1967299 DB ELISA APC Rabbit IgG pSer1114 Log in to see Polyclonal
1 ABIN1967333 DB ELISA APC Rabbit IgG pSer999 Log in to see Polyclonal
1 ABIN1967345 DB ELISA APC Rabbit IgG pTyr1140 Log in to see Polyclonal
1 ABIN1967346 DB ELISA APC Rabbit IgG pTyr1197 Log in to see Polyclonal
1 ABIN1967249 DB ELISA Alkaline Phosphatase (AP) Rabbit IgG pSer999 Log in to see Polyclonal
1 ABIN1967442 DB ELISA Biotin Rabbit IgG pSer1051 Log in to see Polyclonal
1 ABIN1967445 DB ELISA Biotin Rabbit IgG pSer1114 Log in to see Polyclonal

General

Antigen V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Antibodies
Epitope pSer1114
(101), (95), (72), (69), (62), (55), (55), (48), (46), (35), (26), (22), (22), (21), (20), (20), (20), (20), (20), (20), (20), (20), (19), (19), (19), (19), (18), (17), (15), (15), (13), (13), (13), (12), (11), (8), (8), (8), (8), (8), (7), (7), (6), (6), (5), (5), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Mouse (Murine)
(1374), (493), (325), (36), (34), (15), (13), (8), (6), (5), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1)
Host Rabbit
(1005), (512), (30), (16), (12), (5), (1)
Clonality (Clone)
Polyclonal   ( )
Conjugate This HER2 antibody is un-conjugated
(76), (66), (59), (54), (46), (41), (19), (19), (12), (12), (11), (10), (10), (9), (8), (8), (8), (8), (8), (7), (7), (7), (7), (7), (7), (7), (7), (6), (3), (2), (2)
Application Dot Blot (DB)
(716), (602), (318), (314), (309), (308), (267), (132), (112), (102), (89), (21), (19), (18), (8), (6), (6), (5), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-HER2 Antibody

Target Details HER2 Application Details Handling ProductDetails: References for anti-HER2 antibody (ABIN1881311) Images
Predicted Reactivity Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Immunogen This mouse ERBB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1114 of mouse ERBB2.
Clone RB40082

Target Details HER2

Product Details anti-HER2 Antibody Application Details Handling ProductDetails: References for anti-HER2 antibody (ABIN1881311) Images back to top
Antigen
Alternative Name ERBB2 (ERBB2 Antibody Abstract)
Background This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Synonyms: Erbb2, Kiaa3023, Neu, Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, CD_antigen=CD340, Flags: Precursor
NCBI Accession NP_001003817
UniProt P70424
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development

Application Details

Product Details anti-HER2 Antibody Target Details HER2 Handling ProductDetails: References for anti-HER2 antibody (ABIN1881311) Images back to top
Application Notes DB: 1:500
Restrictions For Research Use only

Handling

Product Details anti-HER2 Antibody Target Details HER2 Application Details ProductDetails: References for anti-HER2 antibody (ABIN1881311) Images back to top
Format Liquid
Concentration 0.47 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

ProductDetails: References for anti-HER2 antibody (ABIN1881311)

Product Details anti-HER2 Antibody Target Details HER2 Application Details Handling Images back to top
Product cited in:

Cabodi, Tinnirello, Bisaro, Tornillo, del Pilar Camacho-Leal, Forni, Cojoca, Iezzi, Amici, Montani, Eva, Di Stefano, Muthuswamy, Tarone, Turco, Defilippi: "p130Cas is an essential transducer element in ErbB2 transformation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 10, pp. 3796-808, 2010

Johnson, Seachrist, DeLeon-Rodriguez, Lozada, Miedler, Abdul-Karim, Keri: "HER2/ErbB2-induced breast cancer cell migration and invasion require p120 catenin activation of Rac1 and Cdc42." in: The Journal of biological chemistry, Vol. 285, Issue 38, pp. 29491-501, 2010

Huck, Pontier, Zuo, Muller: "beta1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 35, pp. 15559-64, 2010

Chuang, Chen, Lin, Veeramani, Kumar, Batra, Tu, Lin: "Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth." in: The Journal of biological chemistry, Vol. 285, Issue 31, pp. 23598-606, 2010

Simeone, Straubinger, Khan, Nalleweg, Cheusova, Hashemolhosseini: "Identification of Erbin interlinking MuSK and ErbB2 and its impact on acetylcholine receptor aggregation at the neuromuscular junction." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 19, pp. 6620-34, 2010

Images

Product Details anti-HER2 Antibody Target Details HER2 Application Details Handling ProductDetails: References for anti-HER2 antibody (ABIN1881311) back to top
Supplier Images
Dot Blot (DB) image for anti-V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) (pSer1114) antibody (ABIN1881311) Dot blot analysis of mouse ERBB2 Antibody (Phospho S1114) Phospho-specific Pab (ABIN1...