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anti-Mouse (Murine) HER2 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended HER2 Antibody (supplied by: Log in to see )

Antigen
V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Antibodies
  • c-erbB2
  • c-neu
  • CD340
  • Erbb-2
  • HER-2
  • HER-2/neu
  • HER2
  • mKIAA3023
  • MLN 19
  • NEU
  • Neu
  • NGL
  • TKR1
Epitope
C-Term
115
82
64
54
54
51
51
44
36
32
32
29
21
20
20
20
20
19
19
19
19
19
19
18
18
18
15
14
14
14
13
13
13
12
10
10
9
8
8
8
7
7
7
7
7
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
5
5
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
1145
406
233
24
12
4
3
3
3
3
2
2
1
1
1
Host
Chicken
937
351
19
17
5
5
Clonality
Polyclonal
Conjugate
This HER2 antibody is un-conjugated
67
62
53
45
45
41
9
9
8
8
8
8
8
8
8
2
2
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
623
514
323
319
215
181
133
112
90
45
21
16
12
6
6
5
5
5
3
3
2
2
1
1
1
1
Supplier
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Catalog No. ABIN499802
$ 401.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.34059706 ABIN498415 IF IHC (p) WB Rabbit Log in to see Polyclonal
0.34059706 ABIN498846 IHC (p) Rabbit pTyr877 Log in to see Polyclonal
0.34059706 ABIN498847 IHC (p) Rabbit pTyr1248 Log in to see Polyclonal
0.34059706 ABIN498936 IHC (p) Rabbit Log in to see Polyclonal
0.34059706 ABIN498935 IHC (p) Rabbit Log in to see Polyclonal
0.00089869933 ABIN181400 IHC (p) IP WB Rabbit C-Term Log in to see Polyclonal 1
0.00089869933 ABIN197226 IF IHC (p) WB Rabbit AA 1246-1250 Log in to see Polyclonal 4
0.00089869933 ABIN196748 IF IHC (p) WB Rabbit pTyr877 Log in to see Polyclonal 2
0.00089869933 ABIN196756 IF IHC (p) WB Rabbit pTyr1248 Log in to see Polyclonal 4
0.00089869933 ABIN197222 IHC (p) WB Rabbit Tyr877 Log in to see Polyclonal 3
0.00089869933 ABIN265464 EIA IHC (p) WB Rabbit Log in to see Polyclonal
0.00089869933 ABIN265465 EIA IHC (p) WB Rabbit Log in to see Polyclonal
0.00089869933 ABIN265462 IHC (p) WB Rabbit Log in to see Polyclonal
0.00089869933 ABIN372478 IHC (fro) IHC (p) IP WB Rabbit IgG AA 1243-1255 Log in to see Polyclonal
0.00089869933 ABIN318038 EIA IHC (p) IP WB Rabbit pTyr877 Log in to see Polyclonal
0.00089869933 ABIN318037 IHC (p) WB Rabbit pTyr1248 Log in to see Polyclonal
0.00089869933 ABIN318035 IHC (p) IP WB Rabbit pTyr1221, pTyr1222 Log in to see Polyclonal
0.00089869933 ABIN373271 IHC (p) Rabbit C-Term Log in to see Polyclonal
0.00089869933 ABIN752398 IF (p) IHC (p) WB Rabbit IgG AA 660-700, pThr686 Log in to see Polyclonal
0.00089869933 ABIN372163 IF IHC (p) WB Chicken AA 153-433 Log in to see Polyclonal

Similar anti-HER2 Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
Dot Blot (DB) 19 Antibodies 113 Antibodies
ELISA 68 Antibodies 152 Antibodies
Enzyme Immunoassay (EIA) 6 Antibodies 6 Antibodies
Flow Cytometry (FACS) 4 Antibodies 4 Antibodies
Immunochromatography (IC) 3 Antibodies
Immunocytochemistry (ICC) 7 Antibodies
Immunofluorescence (IF) 48 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 45 Antibodies
Immunohistochemistry (IHC) 84 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 4 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 43 Antibodies
Immunoprecipitation (IP) 26 Antibodies
Western Blotting (WB) 142 Antibodies

General

Antigen V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Antibodies
Epitope C-Term
(115), (82), (64), (54), (54), (51), (51), (44), (36), (32), (32), (29), (21), (20), (20), (20), (20), (19), (19), (19), (19), (19), (19), (18), (18), (18), (15), (14), (14), (14), (13), (13), (13), (12), (10), (10), (9), (8), (8), (8), (7), (7), (7), (7), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (5), (5), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(1145), (406), (233), (24), (12), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1)
Host Chicken
(937), (351), (19), (17), (5), (5)
Clonality
Polyclonal
Conjugate This HER2 antibody is un-conjugated
(67), (62), (53), (45), (45), (41), (9), (9), (8), (8), (8), (8), (8), (8), (8), (2), (2), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(623), (514), (323), (319), (215), (181), (133), (112), (90), (45), (21), (16), (12), (6), (6), (5), (5), (5), (3), (3), (2), (2), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-HER2 Antibody

Target Details HER2 Application Details Handling References for anti-HER2 Antibody (ABIN499802) Images
Specificity This antibody reacts to erbB-2.
Purification Affinity chromatography purified via peptide column
Immunogen erbB-2 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human erbB-2.
Isotype IgG

Target Details HER2

Product Details anti-HER2 Antibody Application Details Handling References for anti-HER2 Antibody (ABIN499802) Images back to top
Antigen
Alternative Name CD340 / ERBB2 / HER2 (ERBB2 Antibody Abstract)
Background The ErbB family consists of four closely related tyrosine kinase receptors that act as potent mediators of normal cell growth and development. Aberrant expression or function of one or more of these receptors can play a major role in the development and evolution of cancer. ErbB-2, also known as HER2, has been implicated in the evolution of both breast and gastric cancers, and is evident in other cancer types such as ovarian and salivary gland tumors. ErbB-2 possesses an active tyrosine kinase domain, but no direct ligand has been identified yet. ErbB-2 is the preferred binding partner to the other members of the ErbB family and is thought to act primarily through the Ras-MAPK, PI3k-PKB/Akt, and PLC-PKC signaling pathways. Numerous anti-cancer strategies have been employed against erbB-2, such as antibody-based therapies to prevent ligand binding or receptor activation through dimerization, antibody-dependent cell mediated cytotoxicity, in addition to direct kinase inhibition to prevent molecular activation/downstream signaling.Synonyms: HER-2, MNL19, NEU, NEU proto-oncogene, NGL, Receptor tyrosine-protein kinase erbB-2, Tyrosine kinase-type cell surface receptor HER2, c-erbB-2, p185erbB2
Gene ID 2064
NCBI Accession NP_004439
UniProt P04626
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-HER2 Antibody Target Details HER2 Handling References for anti-HER2 Antibody (ABIN499802) Images back to top
Application Notes ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-HER2 Antibody Target Details HER2 Application Details References for anti-HER2 Antibody (ABIN499802) Images back to top
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.

References for anti-HER2 Antibody (ABIN499802)

Product Details anti-HER2 Antibody Target Details HER2 Application Details Handling Images back to top
Background publications

Baselga, Swain: "Novel anticancer targets: revisiting ERBB2 and discovering ERBB3." in: Nature reviews. Cancer, Vol. 9, Issue 7, pp. 463-75, 2009

Vermeij, Teugels, Bourgain, Xiangming, in t Veld, Ghislain, Neyns, De Grève: "Genomic activation of the EGFR and HER2-neu genes in a significant proportion of invasive epithelial ovarian cancers." in: BMC cancer, Vol. 8, pp. 3, 2008

Manno: "Measurement of the digit lengths and the anogenital distance in mice." in: Physiology & behavior, Vol. 93, Issue 1-2, pp. 364-8, 2008

Marmor, Skaria, Yarden: "Signal transduction and oncogenesis by ErbB/HER receptors." in: International journal of radiation oncology, biology, physics, Vol. 58, Issue 3, pp. 903-13, 2004

Slamon, Clark, Wong, Levin, Ullrich, McGuire: "Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene." in: Science (New York, N.Y.), Vol. 235, Issue 4785, pp. 177-82, 1987

Images

Product Details anti-HER2 Antibody Target Details HER2 Application Details Handling References for anti-HER2 Antibody (ABIN499802) back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-HER2 antibody (V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian)) (C-Term) (ABIN499802) Immunohistochemistry of erbB-2 in human liver tissue with erbB-2 antibody at 2.5 μg/ml.
Western Blotting (WB) image for anti-HER2 antibody (V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian)) (C-Term) (ABIN499802) Western blot analysis of erbB-2 in rat liver tissue lysate with AP30319PU-N erbB-2 an...