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Human HER2 ELISA Kit for Sandwich ELISA - ABIN921095
Tao, Suhua, Juanjuan, Zongzhi, Juan, Dandan: In vitro study on human cytomegalovirus affecting early pregnancy villous EVT's invasion function. in Virology journal 2011
Human HER2 ELISA Kit for Sandwich ELISA - ABIN625296
Laidi, Bouziane, Lakhdar, Khabouze, Rhrab, Zaoui: Salivary expression of soluble HER2 in breast cancer patients with positive and negative HER2 status. in OncoTargets and therapy 2014
the antibody-sialidase conjugate desialylated tumor cells in a HER2-dependent manner, reduced binding by natural killer (NK) cell inhibitory sialic acid-binding Ig-like lectin (Siglec) receptors, and enhanced binding to the NK-activating receptor natural killer group 2D (NKG2D (show KLRK1 ELISA Kits)).
High HER2 expression is associated with gastric cancer.
In the CNIO-BR-003/GEICAM/2010-10 study, we were able to show a predictive role of 18F-FMISO-PET in HER2-negative early breast cancer treated with nintedanib, detecting the patients that do not experience benefit from it based on baseline tumor oxygenation levels
High HER2 expression is associated with non-small cell lung cancer.
Although new treatments have been approved for patients with ER+/HER2- advanced or MBC (show DOCK2 ELISA Kits) in the past decade, neither survival nor QoL appear to have improved significantly.
HER2 reduces the radiosensitivity of breast cancer by activating Fak (show PTK2 ELISA Kits) in vitro and in vivo.
HER2 insertion could define a distinct subset of NSCLC, which had a higher prevalence among females, nonsmokers, and adenocarcinoma. HER2 should be in the clinical genotyping of lung cancer, so patients may benefit from HER2-targeted therapy.
Data show that epidermal growth factor receptor (show EGFR ELISA Kits) 2 (HER2) single-point substations such as D769H and D769Y as well as the gatekeeper mutation T798 M were predicted to cause strong resistance for an array of tyrosine kinase (show TXK ELISA Kits) inhibitors (TKIs) by reshaping the geometric feature and physiochemical property of the active site.
Anti-HER-2 and hormonal therapy, except tamoxifen, have been underutilized in Korean male breast cancer patients compared to female breast cancer patients.
Data show that inhibition of S100 calcium binding protein P (S100P (show S100P ELISA Kits)) results in reversing trastuzumab resistance (TzR) in proto-oncogene (show RAB1A ELISA Kits) protein HER-2 (HER2)-driven breast cancers.
YAP (show YAP1 ELISA Kits) accumulated in nuclei of mammary glands in ErbB2/EGFR (show EGFR ELISA Kits)-transgenic mice, suggesting that EGFR (show EGFR ELISA Kits) signaling affects YAP (show YAP1 ELISA Kits) in vivo similar to cell culture. ErbB2/EGFR (show EGFR ELISA Kits)-transgenic mice develop mammary tumors in 7-8 months, but surprisingly, MaSCs from these mice did not form tumors when transplanted into host mice.
Results indicate the importance of the LDL receptor (LDLR (show LDLR ELISA Kits)) in the growth of triple-negative and HER2-overexpressing breast cancers in the setting of elevated circulating LDL cholesterol (LDL-C).
immunocompetent mouse models of HER2/ErbB2-driven breast cancer, CD73 expression by tumor cells and host cells significantly suppressed immune-mediated responses mediated by anti-ErbB2 mAb.
We further demonstrate that loss of one allele of PTEN is sufficient to shift isoform dependency from p110alpha (show PIK3CA ELISA Kits) to p110beta in vivo. These results provide insight into the molecular mechanism by which ErbB2-positive breast cancer escapes p110alpha (show PIK3CA ELISA Kits) inhibition.
sought to further echocardiographically characterize the ErbB2(tg) mouse line as a model of hypertrophic obstructive cardiomyopathy
investigations revealed that NUMB (show NUMB ELISA Kits) and NUMBL (show NUMBL ELISA Kits) interacted with small GTPase (show RACGAP1 ELISA Kits) Rab7 (show RAB7A ELISA Kits) to transition ERBB2 from early to late endosome for degradation.
Combined targeting of TGF-beta (show TGFB1 ELISA Kits), EGFR (show EGFR ELISA Kits) and HER2 signaling suppresses lymphangiogenesis and metastasis in a pancreatic ductal adenocarcinoma model.
The conjugation of benzylguanine-modified auristatin F to EGFR (show EGFR ELISA Kits)-specific 425(scFv)-SNAP and HER2-specific alphaHER2(scFv)-SNAP resulted in two potent recombinant antibody-drug conjugates that specifically killed breast cancer cell lines by inducing apoptosis when applied at nanomolar concentrations.
ErbB2 is required for neonatal cardiomyocyte proliferation. ErbB2 conditional knockout heart exhibited an upregulation of negative cell cycle regulators.
Despite previous evidence suggesting that ErbB (show EGFR ELISA Kits) receptors can bind and activate IRSs, our findings indicate that ErbB2 does not cooperate with the IRS (show IARS ELISA Kits) pathway in mouse breast cancer model.
Newly synthesized N-cadherin (show CDH2 ELISA Kits) molecules move from the lateral to the basal surface of cardiomyocytes during trabeculation. This localization requires Erbb2 signaling.
these results suggest that Nrg1 (show NRG1 ELISA Kits) is not the primary effector of trabeculation and/or that other EGF (show EGF ELISA Kits)-like ligand(s) activates the ErbB2/ErbB4 (show ERBB4 ELISA Kits) pathway, either through functioning as the primary ligand or acting in a redundant manner. Overall, our work provides an example of cross-species differences in EGF (show EGF ELISA Kits) family member requirements for an evolutionary conserved process.
Embryos homozygous for a GBT insertion within neuregulin 2a (nrg2a) revealed a novel requirement for a Neuregulin 2a (Nrg2a)-ErbB2/3-AKT (show AKT1 ELISA Kits) signaling pathway governing the organization of a subset of epidermal cells during median fin fold morphogenesis.
A direct link was found between Erbb2 activity and remodeling of myofibrils.
Study shows that, in addition to its role in cardiomyocyte proliferation, ErbB2 is also required for regulating cardiomyocyte migration (delamination) to initiate cardiac trabeculation.
erbb3 (show ERBB3 ELISA Kits) and erbb2 are essential for schwann cell migration and myelination in zebrafish.
NRG1 (show NRG1 ELISA Kits) and PI3K functionally interact with ErbB2 and ErbB3 (show ERBB3 ELISA Kits) during regeneration
Results indicated that most periocular squamous cell carcinomas of horses expressed epidermal growth factor receptor (EGFR (show EGFR ELISA Kits)) and human epidermal growth factor receptor (show EGFR ELISA Kits) 2 (HER2).[HER2]
Widespread expression of ErbB2 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization, with higher levels in grey matter compared to white matter.
We have isolated the cDNA encoding the rhesus monkey homolog of human Her2/neu (RhErbB2) to construct DNA plasmids and adenoviral vectors for the development of a cancer vaccine against this protein.
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
c-erb B2/neu protein
, metastatic lymph node gene 19 protein
, neuro/glioblastoma derived oncogene homolog
, neuroblastoma/glioblastoma derived oncogene homolog
, proto-oncogene Neu
, proto-oncogene c-ErbB-2
, receptor tyrosine-protein kinase erbB-2
, tyrosine kinase-type cell surface receptor HER2
, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
, Neu oncogene
, avian erythroblastosis oncogene B 2
, proto-oncogene NEU
, Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog)
, NEU proto-oncogene
, epidermal growth factor receptor-related protein
, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
, epidermal growth factor receptor type 2