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Human HER2 ELISA Kit for Sandwich ELISA - ABIN921095
Tao, Suhua, Juanjuan, Zongzhi, Juan, Dandan: In vitro study on human cytomegalovirus affecting early pregnancy villous EVT's invasion function. in Virology journal 2011
Human HER2 ELISA Kit for Sandwich ELISA - ABIN625296
Laidi, Bouziane, Lakhdar, Khabouze, Rhrab, Zaoui: Salivary expression of soluble HER2 in breast cancer patients with positive and negative HER2 status. in OncoTargets and therapy 2014
similarities in HER2 amplification status between the in situ and invasive component of admixed tumors hint at a common biological pathway for both components
HER2 amplification in the invasive carcinomas was negative in 87% of the cases and positive in 13% of the cases
EGFR (show EGFR ELISA Kits) and/or HER2 transactivation is involved in cell adhesion, cell migration and VEGF (show VEGFA ELISA Kits) secretion produced by GHRH (show GHRH ELISA Kits).
Evaluation of progesterone expression in axillary lymph node metastasis of ER-positive, HER2-negative breast cancer may enable prediction of patients who are less likely to benefit from adjuvant tamoxifen.
Data suggest that three new candidate genes involved in the development of rheumatoid arthritis (RA): ERBB2, TP53 (show TP53 ELISA Kits) and THOP1 (show THOP1 ELISA Kits).
ERBB2 Exon 20 Insertion-Mutation is associated with response to chemotherapy in Lung Adenocarcinomas.
Review of the role of HER-2 mutation in non-small cell lung carcinoma development, diagnosis, and treatment.
Patients with activating exon 20 HER2 mutations appear to have worse survival out- comes compared with other patients with lung adenocar- cinomas with oncogenic drivers.
human epidermal growth factor receptor (show EGFR ELISA Kits) 2 (HER-2) levels, were correlated well with TSP50 (show PRSS50 ELISA Kits)/p-Samd2/3 and TSP50 (show PRSS50 ELISA Kits)/p27 (show PAK2 ELISA Kits) expression status. Thus, our studies revealed a novel regulatory mechanism underlying TSP50 (show PRSS50 ELISA Kits)-induced cell proliferation and provided a new favorable intervention target for the treatment of breast cancer
relevant genomic aberrations such as mutations in the hotspot regions of exon 9 and 20 of the PIK3CA (show PIK3CA ELISA Kits) gene can be detected in single circulating tumor cells and might provide insights into mechanisms of resistance to HER2-targeted therapies.
immunocompetent mouse models of HER2/ErbB2-driven breast cancer, CD73 expression by tumor cells and host cells significantly suppressed immune-mediated responses mediated by anti-ErbB2 mAb.
We further demonstrate that loss of one allele of PTEN is sufficient to shift isoform dependency from p110alpha (show PIK3CA ELISA Kits) to p110beta in vivo. These results provide insight into the molecular mechanism by which ErbB2-positive breast cancer escapes p110alpha (show PIK3CA ELISA Kits) inhibition.
sought to further echocardiographically characterize the ErbB2(tg) mouse line as a model of hypertrophic obstructive cardiomyopathy
investigations revealed that NUMB (show NUMB ELISA Kits) and NUMBL (show NUMBL ELISA Kits) interacted with small GTPase (show RACGAP1 ELISA Kits) Rab7 (show RAB7A ELISA Kits) to transition ERBB2 from early to late endosome for degradation.
Combined targeting of TGF-beta (show TGFB1 ELISA Kits), EGFR (show EGFR ELISA Kits) and HER2 signaling suppresses lymphangiogenesis and metastasis in a pancreatic ductal adenocarcinoma model.
The conjugation of benzylguanine-modified auristatin F to EGFR (show EGFR ELISA Kits)-specific 425(scFv)-SNAP and HER2-specific alphaHER2(scFv)-SNAP resulted in two potent recombinant antibody-drug conjugates that specifically killed breast cancer cell lines by inducing apoptosis when applied at nanomolar concentrations.
ErbB2 is required for neonatal cardiomyocyte proliferation. ErbB2 conditional knockout heart exhibited an upregulation of negative cell cycle regulators.
Despite previous evidence suggesting that ErbB (show EGFR ELISA Kits) receptors can bind and activate IRSs, our findings indicate that ErbB2 does not cooperate with the IRS (show IARS ELISA Kits) pathway in mouse breast cancer model.
It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis
Study showed that suppression of STAT3 (show STAT3 ELISA Kits), STAT5 (show STAT5A ELISA Kits), and STAT6 (show STAT6 ELISA Kits) and overexpression of the proapoptotic factor STAT1 (show STAT1 ELISA Kits), which provides p53 (show TP53 ELISA Kits)-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 tyrosine kinase receptor (show KDR ELISA Kits) overexpression promotes neuronal survival through activation of STAT (show STAT1 ELISA Kits)-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1 (show STAT1 ELISA Kits)
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
c-erb B2/neu protein
, metastatic lymph node gene 19 protein
, neuro/glioblastoma derived oncogene homolog
, neuroblastoma/glioblastoma derived oncogene homolog
, proto-oncogene Neu
, proto-oncogene c-ErbB-2
, receptor tyrosine-protein kinase erbB-2
, tyrosine kinase-type cell surface receptor HER2
, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
, Neu oncogene
, avian erythroblastosis oncogene B 2
, proto-oncogene NEU
, Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog)
, NEU proto-oncogene
, epidermal growth factor receptor-related protein
, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
, epidermal growth factor receptor type 2