Browse our IGF1 Proteins (IGF1)

Full name:
Insulin-Like Growth Factor 1 Proteins (IGF1)
On www.antibodies-online.com are 170 Insulin-Like Growth Factor 1 (IGF1) Proteins from 25 different suppliers available. Additionally we are shipping IGF1 Antibodies (444) and IGF1 Kits (184) and many more products for this protein. A total of 813 IGF1 products are currently listed.
Synonyms:
C730016P09Rik, IGF-1, IGF-1a, IGF-1L, Igf-I, IGF-IB, IGF1, IGF1A, IGFI, IGFIA, Npt2B
list all proteins Gene Name GeneID UniProt
IGF1 3479 P05019
IGF1 16000 P05017
IGF1 24482 P08025

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IGF1 Proteins (IGF1) by Origin

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Top referenced IGF1 Proteins

  1. Human IGF1 Protein expressed in Escherichia coli (E. coli) - ABIN2666830 : Mohan, Baylink: IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms. in The Journal of endocrinology 2002 (PubMed)
    Show all 7 references for 2666830

  2. Mouse (Murine) IGF1 Protein expressed in Escherichia coli (E. coli) - ABIN2666831 : Brisson, Barton: New Modulators for IGF-I Activity within IGF-I Processing Products. in Frontiers in endocrinology 2013 (PubMed)
    Show all 6 references for 2666831

  3. Rat (Rattus) IGF1 Protein expressed in Escherichia coli (E. coli) - ABIN2666833 : Barton, Park, James, Makarewich, Philippou, Eletto, Lei, Brisson, Ostrovsky, Li, Argon: Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 (PubMed)
    Show all 5 references for 2666833

  4. Human IGF1 Protein expressed in Escherichia coli (E. coli) - ABIN413398 : Robertson, Zhu, Wu: Cellular distribution of the IGF-1R in corneal epithelial cells. in Experimental eye research 2011 (PubMed)
    Show all 4 references for 413398

  5. Human IGF1 Protein expressed in Escherichia coli (E. coli) - ABIN2003114 : Dull, Gray, Hayflick, Ullrich: Insulin-like growth factor II precursor gene organization in relation to insulin gene family. in Nature 1984 (PubMed)
    Show all 4 references for 2003114

  6. Human IGF1 Protein expressed in HEK-293 Cells - ABIN2181262 : Qin, Strong, Baylink, Mohan: Structure-function analysis of the human insulin-like growth factor binding protein-4. in The Journal of biological chemistry 1998 (PubMed)

More Proteins for IGF1 Interaction Partners

Zebrafish Insulin-Like Growth Factor 1 (IGF1) interaction partners

  1. Study demonstrated that IGF-I can stimulate egfr (show EGFR Proteins) expression in both follicles cell culture and intact follicles promoting oocyte maturation.

  2. IGF-I-induced kitlga expression is inhibited by epidermal growth factor (show EGF Proteins), an oocyte-derived paracrine factor in the zebrafish follicle.

  3. hypoxia causes PGC (show PGC Proteins) migration defect by inhibiting IGF signaling through the induction of IGFBP-1 (show IGFBPI Proteins)

  4. Whereas hypoxia repressed the Igf1 receptor and its downstream Erk1/2 and Akt (show AKT1 Proteins) signaling activities, re-oxygenation restored their activities

  5. IGF signalling influences expression of BMP2b (show BMP4 Proteins), a gene that plays an important role in zebrafish pattern formation

  6. The insulin-like growth factor 1 gene can be differentially transcribed to yield two distinct IGF-1 mRNA transcripts

  7. zebrafish XBP-1 (show XBP1 Proteins) spliced form not only activates genes responsible for protein folding, transporting, glycosylation and Endoplasmic Reticulum associated degradation but also activates anti-apoptosis signal via IGF1/Akt (show AKT1 Proteins) pathway in unfolded protein

Mouse (Murine) Insulin-Like Growth Factor 1 (IGF1) interaction partners

  1. These results demonstrate that a greater than additive effect is observed on the growth of skeletal muscle and in the reduction of body fat when myostatin (show MSTN Proteins) is absent and IGF1 is in excess (show RCC1 Proteins), and that myostatin (show MSTN Proteins) and IGF1 regulate skeletal muscle size, myofibre type and gonadal fat through distinct mechanisms.

  2. Confirmation of the impairment of GH-IGF-1 release in hyperphagic MC4R (show MC4R Proteins) KO mice suggests a role for insulin (show INS Proteins) in regulating both the release of GH, but also in mediating growth during periods of physiologically suppressed GH-IGF-1 levels

  3. These results indicate that IGF-1 plays a critical role in spermatogenesis from SSCs.

  4. Exercise negatively regulates IGF-1 pathway in skin epidermis.

  5. A role for IGF-1 in axon elongation that appears to be cell selective and participates in the complex cellular mechanisms that link underfeeding during the early postnatal period with programming of the growth trajectory.

  6. These findings demonstrate that the AMPK (show PRKAA1 Proteins)-TBC1D1 (show TBC1D1 Proteins) signaling nexus interacts with the PKB (show AKT2 Proteins)-mTOR (show FRAP1 Proteins) pathway via IGF1 secretion, which consequently controls expression of lipogenic genes in the adipose tissue

  7. Increased diet-induced fatty streak formation in female Liver derived-IGF-I(-/-) mice was associated with increased serum cholesterol and signs of systemic inflammation, endothelial activation, lipid deposition, and macrophage infiltration in the vascular wall.

  8. findings represent the first demonstration to our knowledge of tissue IGF-1 regulation through proteolytic degradation and suggest that chymase (show CMA1 Proteins) inhibition may be a viable therapeutic approach to enhance late cardioprotection in postischemic heart disease

  9. Experimental NAFLD is associated with sarcopenia, decreased muscle strength, and reduced IGF-1 serum levels. IGF-1 reduction may be involved in pathogenesis of NAFLD-associated sarcopenia.

  10. vascular smooth muscle-derived IGF-1 plays a critical role in hypoxia-induced pulmonary hypertension.

Guinea Pig Insulin-Like Growth Factor 1 (IGF1) interaction partners

  1. Local IGF-1 might play a role in the lesion- and deafness-induced plasticity in FC and at AN/FC synapse following chronic kanamycin-induced deafness.

Human Insulin-Like Growth Factor 1 (IGF1) interaction partners

  1. We found that the thyroid hormone receptor (show THRA Proteins) (TRalpha (show THRA Proteins) 3) has a differential expression profile. Thyroid hormone (show PTH Proteins) is critical for normal brain development. Our results showed that there is a possible link between IGF1/IGF1R (show IGF1R Proteins) and the TRalpha (show THRA Proteins) 3 and that over expression of IGF1R (show IGF1R Proteins) in RTT cells may be the cause of neurites improvement in neural RTT-derived neurons.

  2. Increased IGF1 level as associated with decreased risk of frailty in men.

  3. These patients provide important insights into the regulation of longitudinal growth in humans, documenting the critical role of PAPP-A2 (show PAPPA2 Proteins) in releasing IGF-I from its binding proteins.

  4. The stimulation by DHEA on both IGF-I gene expression and osteoblastogenesis in hMSCs requires IGF-I receptor (show IGF1R Proteins), PI3K (show PIK3CA Proteins), p38 MAPK (show MAPK14 Proteins), or p42 (show EPB42 Proteins)/44 MAPK (show MAPK1 Proteins) signaling pathways.

  5. IGF-1 promotes proliferation and collagen synthesis of human periodontal ligament stem cells, which further accelerates the differentiation into periodontal ligament fibroblast cells.

  6. The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR (show FRAP1 Proteins) and PPARg (show PPARG Proteins). In summary, PPARg (show PPARG Proteins) plays an important role in the regulation of IGF-1 secretion and gene expression in response to dietary protein.

  7. IGF-1 levels were inversely associated with ischemic stroke, especially among persons with insulin (show INS Proteins) resistance.

  8. Serum BDNF (show BDNF Proteins), VEGF (show VEGFA Proteins), and IGF-1 levels were significantly higher in the Taekwondo (TKD) training group after the 16-week intervention. The training may have been effective in increasing children's cognitive function by inducing an increase in the levels of neuroplasticity-related growth factors.

  9. Report serum IGF1/IGFBP3 (show IGFBP3 Proteins) levels in relation to clinical/pathobiological features of squamous cell carcinomas of the head and neck.

  10. IGF-1Ec isoform stimulates the proliferation and migration of MCF-7 breast cancer cells and enhances the intracellular ERK1/2 signaling

Cow (Bovine) Insulin-Like Growth Factor 1 (IGF1) interaction partners

  1. Thus CR suppresses the hypertrophic PGC1alpha-4/IGF-1/AKT1 pathway while promoting activation of the calpain system.

  2. Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.

  3. IGF1 single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.

  4. It has been shown that several specific genes which are differentially regulated, including IGF-1, might impact dairy fertility.

  5. There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 (show STAT5A Proteins) ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.

  6. Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle.

  7. The association of IGF1, GH, and PIT1 (show POU1F1 Proteins) markers with growth and reproductive traits were assessed.

  8. These findings strongly support the concept that IGF-1 upregulates LHR (show LHCGR Proteins) expression in granulosa cells and that IGF-1 is required for determining which follicle becomes dominant and acquires ovulatory capacity.

  9. Insulin (show INS Proteins)-induced glucose uptake in lactating bovine mammary epithelial cells may involve the phosphatidylinositide 3-kinase- but not mitogen-activated protein kinase (show MAPK1 Proteins)-mediated signaling pathways.

  10. Data show that individuals with insulin-like growth factor I (IGF-1) allele C had a significantly higher performance in production traits.

Pig (Porcine) Insulin-Like Growth Factor 1 (IGF1) interaction partners

  1. The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR (show FRAP1 Proteins) and PPARg (show PPARG Proteins). In summary, PPARg (show PPARG Proteins) plays an important role in the regulation of IGF-1 secretion and gene expression in response to dietary protein.

  2. Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.

  3. This study demonstrated that Up-regulation of IGF-1 in the frontal cortex of piglets exposed to an environmentally enriched arena.

  4. Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF (show HGF Proteins) enhances neovascularization but moderately improves cardiac regeneration in a porcine model.

  5. Results show that expression changes of IGF1 genes were associated with C/EBP (show CEBPA Proteins) b expression during embryonic and postnatal development in porcine liver.

  6. genetic association study suggests that the TC genotype of IGF-1 represents the selection genotype for smaller in size.

  7. IGF-I coordinately regulates multiple cell signaling pathways that are critical to proliferation, migration and survival of trophectoderm cells during early pregnancy in pigs.

  8. IGF-1 splice variant (mechano growth factor) is expressed within the growth plate, but the addition of its peptides was not associated with growth plate chondrocytes proliferation.

  9. alpha-linolenic acid increased IGF-I secretion from hepatocytes.

  10. Copper can stimulate chondrocyte proliferation by promoting the expression of IGF-1.

Rabbit Insulin-Like Growth Factor 1 (IGF1) interaction partners

  1. Data suggest caloric restriction modifies response of ovarian granulosa cells to leptin (show LEP Proteins) on cell proliferation/apoptosis, MAP kinase (show MAPK1 Proteins) signaling, and release of hormones (estradiol and IGFI). The caloric restriction studies were conducted in rabbits; then, isolated rabbit granulosa cells were exposed to recombinant human leptin (show LEP Proteins). (IGF1 = insulin-like growth factor I)

  2. Intraplacental gene therapy with Ad-IGF-1 corrects naturally occurring rabbit model of intrauterine growth restriction.

  3. Our studies demonstrate that the active SVCT2 (show SLC23A2 Proteins) is expressed in IVD (show IVD Proteins) cells and that the expression of this transporter is regulated by growth factors IGF-1 and dexamethasone.

  4. increased endogenous IGF1 and IGF2 expression by the blastocyst compensates for the loss of systemic insulin (show INS Proteins) and IGF.

  5. IGF1 showed a significantly higher capacity to form the posterior mesoderm and primitive streak (stage 2 and 3) than blastocysts cultured without growth factors

  6. Overall, IGF-1 promoted atherosclerosis by affecting endothelial function and aging.

Horse (Equine) Insulin-Like Growth Factor 1 (IGF1) interaction partners

  1. Data suggest that metabolism of IGF1, IGF2, and IGFBP3 (insulin-like growth factor binding protein-3 (show IGFBP3 Proteins)) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).

  2. The laminar cell types expressing insulin receptor (show INSR Proteins) and/or insulin-like growth factor-1 receptor (show IGF1R Proteins) and the effect of dietary carbohydrates on their expression are reported.

  3. Increased expression of IGF-1 in female equine embryos. Sex-related influences on expression of the IGF system are probably related to a gradual X chromosome inactivation.

  4. Somatomedin (IGF-I) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor (show IGF1R Proteins) is present in spermatogonia, spermatocytes and Leydig cells.

  5. Hsp90 (show HSP90AB1 Proteins) inhibitor geldanamycin is used to assess age-related responses with IGF1 stimulation of chondrocytes.

Goat Insulin-Like Growth Factor 1 (IGF1) interaction partners

  1. These results suggest the significant influence of the IGF1 gene on prolificacy in goats and identified SNPs would benefit the selection of prolific animals in future breeding programs.

IGF1 Protein Profile

Protein Summary

The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with IGF1

  • insulin-like growth factor 1 (somatomedin C) (IGF1)
  • insulin-like growth factor 1 (Igf1)
  • insulin-like growth factor I (LOC100136741)
  • insulin-like growth factor 1 (igf1)
  • prepro IGF-I (IGF-I)
  • C730016P09Rik protein
  • IGF-1 protein
  • IGF-1a protein
  • IGF-1L protein
  • Igf-I protein
  • IGF-IB protein
  • IGF1 protein
  • IGF1A protein
  • IGFI protein
  • IGFIA protein
  • Npt2B protein

Protein level used designations for IGF1

IGF-IA , IGF-IB , MGF , insulin-like growth factor 1 , insulin-like growth factor I , insulin-like growth factor IA , insulin-like growth factor IB , mechano growth factor , somatomedin-C , somatomedin , IGF-I , somatomedin C , insulin-like growth factor-1 , Insulin-like growth factor I , igf1a , class 1 insulin-like growth factor I preproprotein , insulin growth factor-1 , insulin like growth factor 1 , insulin-like growth factor I (somatomedin C) , insulin-like growth factor I variant 1 , prepro-IGF-I , Somatomedin , insulin like growth factor-1 , insulin-like growth factor-I

GENE ID SPECIES
3479 Homo sapiens
16000 Mus musculus
24482 Rattus norvegicus
397491 Sus scrofa
418090 Gallus gallus
610255 Canis lupus familiaris
100008668 Oryctolagus cuniculus
100136741 Oncorhynchus mykiss
114433 Danio rerio
281239 Bos taurus
443318 Ovis aries
100034198 Equus caballus
100135551 Cavia porcellus
100860838 Capra hircus
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