anti-Human IGF1R antibody for Depletion

Recommended IGF1R Antibody (supplied by: Log in to see )

Antigen
Insulin-Like Growth Factor 1 Receptor (IGF1R) Antibodies
  • CD221
  • IGFIR
  • IGFR
  • JTK13
  • IGFIRC
  • IGFR1
  • IGF-1R
  • IGF1R
  • DKFZp469I0618
  • igf-1r
  • xIGF-1R
  • xIGFR
  • xigf1r
  • A330103N21Rik
  • D930020L01
  • hyft
  • igf-ir
  • insulin-like growth factor 1 receptor
  • insulin-like growth factor I receptor
  • IGF1R
  • Igf1r
  • igf1r
  • LOC780503
  • igf-ir
Reactivity
Human
496
250
238
18
15
11
7
7
6
5
5
5
2
2
1
Host
Mouse
366
127
2
2
Clonality
Monoclonal
Conjugate
This IGF1R antibody is conjugated to PE
21
18
16
15
9
9
8
8
8
8
8
8
8
8
8
7
6
4
Application
Depletion (Dep), Flow Cytometry (FACS), Immunohistochemistry (IHC)
311
116
104
103
88
83
48
41
8
6
6
4
3
2
1
1
1
1
1
1
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Catalog No. ABIN2662549
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2662550 Dep FACS IHC PE Mouse IgG1 kappa Log in to see 1H7-CD221 7

General

Antigen Insulin-Like Growth Factor 1 Receptor (IGF1R) Antibodies
Reactivity Human
(496), (250), (238), (18), (15), (11), (7), (7), (6), (5), (5), (5), (2), (2), (1)
Host Mouse
(366), (127), (2), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IGF1R antibody is conjugated to PE
(21), (18), (16), (15), (9), (9), (8), (8), (8), (8), (8), (8), (8), (8), (8), (7), (6), (4)
Application Depletion (Dep), Flow Cytometry (FACS), Immunohistochemistry (IHC)
(311), (116), (104), (103), (88), (83), (48), (41), (8), (6), (6), (4), (3), (2), (1), (1), (1), (1), (1), (1)
Pubmed 7 references available
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Product Details anti-IGF1R Antibody

Target Details IGF1R Application Details Handling References for anti-IGF1R antibody (ABIN2662549) Images
Purification The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Clone 1H7-CD221
Isotype IgG1 kappa

Target Details IGF1R

Product Details anti-IGF1R Antibody Application Details Handling References for anti-IGF1R antibody (ABIN2662549) Images back to top
Antigen
Alternative Name CD221 (IGF1R Antibody Abstract)
Background CD221, also known as insulin-like growth factor 1 receptor (IGF1R), is a 135 kD transmembrane receptor. It is widely expressed on lymphoid and myeloid cells as well as non-haematopoietic cells. CD221 is a tyrosine kinase receptor and the ligands for CD221 are insulin-like growth factor 1 and 2 (IGF-1 and IGF-2), the polypeptide hormones similar in molecular structure to insulin. IGF-1/2 binding activates downstream PI3K and MAPK pathways and plays an important role in cell growth. Recent studies reveal its function of recruiting immune cells during tissue repair.
Pathways RTK Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy

Application Details

Product Details anti-IGF1R Antibody Target Details IGF1R Handling References for anti-IGF1R antibody (ABIN2662549) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IGF1R Antibody Target Details IGF1R Application Details References for anti-IGF1R antibody (ABIN2662549) Images back to top
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-IGF1R antibody (ABIN2662549)

Product Details anti-IGF1R Antibody Target Details IGF1R Application Details Handling Images back to top
Background publications

Pasternack, Domogauer, Khullar, Akudugu, Howell: "The advantage of antibody cocktails for targeted alpha therapy depends on specific activity." in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Vol. 55, Issue 12, pp. 2012-9, 2014

Ohtani, Numazaki, Yajima, Fujita-Yamaguchi: "Mechanisms of antibody-mediated insulin-like growth factor I receptor (IGF-IR) down-regulation in MCF-7 breast cancer cells." in: Bioscience trends, Vol. 3, Issue 4, pp. 131-8, 2010

Kusada, Morizono, Matsumoto-Takasaki, Sakai, Sato, Asanuma, Takayanagi, Fujita-Yamaguchi: "Construction and characterization of single-chain antibodies against human insulin-like growth factor-I receptor from hybridomas producing 1H7 or 3B7 monoclonal antibody." in: Journal of biochemistry, Vol. 143, Issue 1, pp. 9-19, 2008

Baudler, Baumgartl, Hampel, Buch, Waisman, Snapper, Krone, Brüning: "Insulin-like growth factor-1 controls type 2 T cell-independent B cell response." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 9, pp. 5516-25, 2005

Sharp, Jameson, Cauvi, Havran: "Dendritic epidermal T cells regulate skin homeostasis through local production of insulin-like growth factor 1." in: Nature immunology, Vol. 6, Issue 1, pp. 73-9, 2004

Ye, Liang, Guo, Li, Wu, Giannini, Sachdev, Yee, Brünner, Ikle, Fujita-Yamaguchi: "Combined effects of tamoxifen and a chimeric humanized single chain antibody against the type I IGF receptor on breast tumor growth in vivo." in: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme, Vol. 35, Issue 11-12, pp. 836-42, 2004

Li, Liang, Guo, Wu, Fujita-Yamaguchi: "Single-chain antibodies against human insulin-like growth factor I receptor: expression, purification, and effect on tumor growth." in: Cancer immunology, immunotherapy : CII, Vol. 49, Issue 4-5, pp. 243-52, 2000

Images

Product Details anti-IGF1R Antibody Target Details IGF1R Application Details Handling References for anti-IGF1R antibody (ABIN2662549) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) antibody (PE) (ABIN2662549) anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) antibody (PE)
Flow Cytometry (FACS) image for anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) antibody (PE) (ABIN2662549) anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) antibody (PE) (Image 2)