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anti-Mouse (Murine) IGF1R antibody for Intracellular Staining

Recommended IGF1R Antibody (supplied by: Log in to see )

Antigen
Insulin-Like Growth Factor 1 Receptor (IGF1R) Antibodies
  • IGF1R
  • DKFZp469I0618
  • igf-1r
  • xIGF-1R
  • xIGFR
  • xigf1r
  • CD221
  • IGFIR
  • IGFR
  • JTK13
  • IGFIRC
  • IGF-1R
  • IGFR1
  • A330103N21Rik
  • D930020L01
  • hyft
  • insulin-like growth factor 1 receptor
  • insulin-like growth factor I receptor
  • IGF1R
  • igf1r
  • Igf1r
Epitope
pTyr1131
33
30
29
28
24
23
22
16
15
15
15
15
14
13
12
8
7
6
5
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
442
186
184
2
2
2
2
1
1
Host
Mouse
313
124
2
2
Clonality
Monoclonal
Conjugate
This IGF1R antibody is conjugated to Alexa Fluor 647
20
19
17
16
9
8
8
8
8
8
8
8
8
8
8
7
6
Application
Intracellular Staining (ICS)
263
108
104
100
83
71
38
28
8
8
7
3
3
3
2
1
1
1
Options
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Catalog No. ABIN1177067
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Neutralization (Neut) 3 Antibodies
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Immunoprecipitation (IP) 38 Antibodies 7 Antibodies 5 Antibodies
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General

Antigen Insulin-Like Growth Factor 1 Receptor (IGF1R) Antibodies
Epitope pTyr1131
(33), (30), (29), (28), (24), (23), (22), (16), (15), (15), (15), (15), (14), (13), (12), (8), (7), (6), (5), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(442), (186), (184), (2), (2), (2), (2), (1), (1)
Host Mouse
(313), (124), (2), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IGF1R antibody is conjugated to Alexa Fluor 647
(20), (19), (17), (16), (9), (8), (8), (8), (8), (8), (8), (8), (8), (8), (8), (7), (6)
Application Intracellular Staining (ICS)
(263), (108), (104), (100), (83), (71), (38), (28), (8), (8), (7), (3), (3), (3), (2), (1), (1), (1)
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Product Details anti-IGF1R Antibody

Target Details IGF1R Application Details Handling Images
Brand BD Phosflow™
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Phosphorylated Human IGF-1 Receptor
Clone K74-218
Isotype IgG1, kappa

Target Details IGF1R

Product Details anti-IGF1R Antibody Application Details Handling Images back to top
Antigen
Alternative Name CD221 (IGF-1 Receptor) (IGF1R Antibody Abstract)
Background Insulin-like growth factor-1 (IGF-1) receptor, or CD221, is a receptor tyrosine kinase that has high affinity for IGF-1 and low affinity for insulin and IGF-2. Each transmembrane protein complex is formed from a pair of 1367 amino-acid precursor proteins. After the 30 amino-acid signal sequences are removed, the paired polypeptides are cleaved to derive an a and b chain from each. The two extracellular a chains form the ligand-binding domain, while the transmembrane-and-intracellular b chains carry the kinase activity. Upon stimulation by its ligand, IGF-1 receptor autophosphorylates multiple tyrosine sites in its b chains and phosphorylates other signaling mediators that regulate cell growth, development, and neoplastic transformation. The K74-218 monoclonal antibody recognizes the phosphorylated tyrosine 1131 (pY1131) in the activation loop of IGF-1 receptor’s kinase domain. The orthologous phosphorylation sites in mouse and rat IGF-1 receptor are Y1133 and Y1132, respectively.
Pathways RTK Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process

Application Details

Product Details anti-IGF1R Antibody Target Details IGF1R Handling Images back to top
Sample Volume 20 μL
Restrictions For Research Use only

Handling

Product Details anti-IGF1R Antibody Target Details IGF1R Application Details Images back to top
Format Liquid
Buffer Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed. Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.