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|Application / Reactivity||Mouse (Murine)|
|Blocking Reagent (BR)||3 Antibodies|
|Enzyme Immunoassay (EIA)||2 Antibodies|
|Flow Cytometry (FACS)||4 Antibodies|
|Immunocytochemistry (ICC)||2 Antibodies|
|Immunofluorescence (IF)||1 Antibodies|
|Immunohistochemistry (IHC)||2 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||2 Antibodies|
|Immunoprecipitation (IP)||1 Antibodies|
|Western Blotting (WB)||23 Antibodies|
|Antigen||Interleukin 34 (IL34) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This IL34 antibody is un-conjugated Alternatives|
Blocking Reagent (BR), Flow Cytometry (FACS)
|5 references available|
|Supplier||Log in to see|
Product Details anti-IL34 AntibodyTarget Details IL34 Application Details Handling References for anti-IL34 Antibody (ABIN2665836) Images
|Purification||The LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.|
|Sterility||0.2 μm filtered|
Endotoxin level is <0.1 EU/μg of the protein (<0.01 ng/μg of the protein) as determined by the LAL test.
Target Details IL34Product Details anti-IL34 Antibody Application Details Handling References for anti-IL34 Antibody (ABIN2665836) Images back to top
|Alternative Name||IL-34 (IL34 Antibody Abstract)|
|Background||IL-34 is a homodimeric glycoprotein which contains 241 amino acids. IL-34 is expressed in the heart, brain, lung, liver, kidney, thymus, spleen, and other organs. It specifically binds to CD115/M-CSF receptor (CSF-1 receptor or c-Fms) and activates ERK1/2 phosphorylation. The function of IL-34 overlaps with CSF-1 to regulate myeloid lineage differentiation, proliferation, and survival. Elevated levels of IL-34 are seen in the plasma of rheumatoid arthritis patients, but can be decreased in response to therapy. IL-34 levels are also increased in the serum of cancer patients and are associated with poor prognosis. Mouse IL-34 shares 71 % sequence identity with human IL-34 on the amino acid level.|
Application DetailsProduct Details anti-IL34 Antibody Target Details IL34 Handling References for anti-IL34 Antibody (ABIN2665836) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL34 Antibody Target Details IL34 Application Details References for anti-IL34 Antibody (ABIN2665836) Images back to top
|Handling Advice||This LEAF™ solution contains no preservative, handle under aseptic conditions|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-IL34 Antibody (ABIN2665836)Product Details anti-IL34 Antibody Target Details IL34 Application Details Handling Images back to top
Eda, Shimada, Beidler et al.: "Proinflammatory cytokines, IL-1β and TNF-α, induce expression of interleukin-34 mRNA via JNK- and p44/42 MAPK-NF-κB pathway but not p38 pathway in osteoblasts." in: Rheumatology international, Vol. 31, Issue 11, pp. 1525-30, 2011 (PubMed).
Wei, Nandi, Chitu et al.: "Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells." in: Journal of leukocyte biology, Vol. 88, Issue 3, pp. 495-505, 2010 (PubMed).
Chihara, Suzu, Hassan et al.: "IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation." in: Cell death and differentiation, Vol. 17, Issue 12, pp. 1917-27, 2010 (PubMed).
Covaleda, Fuller, Payne: "EIAV S2 enhances pro-inflammatory cytokine and chemokine response in infected macrophages." in: Virology, Vol. 397, Issue 1, pp. 217-23, 2010 (PubMed).
Lin, Lee, Hestir et al.: "Discovery of a cytokine and its receptor by functional screening of the extracellular proteome." in: Science (New York, N.Y.), Vol. 320, Issue 5877, pp. 807-11, 2008 (PubMed).
ImagesProduct Details anti-IL34 Antibody Target Details IL34 Application Details Handling References for anti-IL34 Antibody (ABIN2665836) back to top