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anti-Mouse (Murine) IL34 antibody for Immunofluorescence

Recommended IL34 Antibody (supplied by: Log in to see )

Antigen
Interleukin 34 (IL34) Antibodies
  • 2010004A03Rik
  • AI593503
  • C16orf77
  • C18H16ORF77
  • IL-34
Reactivity
Mouse (Murine)
67
29
20
Host
Goat
55
21
7
3
Clonality
Polyclonal
Conjugate
This IL34 antibody is conjugated to Biotin
12
4
3
2
2
2
Application
Blocking Reagent (BR), Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
65
57
13
6
6
4
3
3
2
2
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Catalog No. ABIN2660791
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Top referenced anti-IL34 antibody for Immunofluorescence

Similar anti-IL34 Antibodies

Application / Reactivity Mouse (Murine)
Blocking Reagent (BR) 3 Antibodies
ELISA 18 Antibodies
Enzyme Immunoassay (EIA) 2 Antibodies
Flow Cytometry (FACS) 4 Antibodies
Immunocytochemistry (ICC) 2 Antibodies
Immunofluorescence (IF) 1 Antibodies
Immunohistochemistry (IHC) 2 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 2 Antibodies
Immunoprecipitation (IP) 1 Antibodies
Western Blotting (WB) 23 Antibodies

General

Antigen Interleukin 34 (IL34) Antibodies
Reactivity Mouse (Murine)
(67), (29), (20)
Host Goat
(55), (21), (7), (3)
Clonality (Clone)
Polyclonal   ( )
Conjugate This IL34 antibody is conjugated to Biotin
(12), (4), (3), (2), (2), (2)
Application Blocking Reagent (BR), Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(65), (57), (13), (6), (6), (4), (3), (3), (2), (2)
Pubmed 5 references available
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Product Details anti-IL34 Antibody

Target Details IL34 Application Details Handling References for anti-IL34 Antibody (ABIN2660791) Images
Purification The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
Clone Poly5193
Isotype Ig Fraction

Target Details IL34

Product Details anti-IL34 Antibody Application Details Handling References for anti-IL34 Antibody (ABIN2660791) Images back to top
Antigen
Alternative Name IL-34 (IL34 Antibody Abstract)
Background IL-34 is a homodimeric glycoprotein which contains 241 amino acids. IL-34 is expressed in the heart, brain, lung, liver, kidney, thymus, spleen, and other organs. It specifically binds to CD115/M-CSF receptor (CSF-1 receptor or c-Fms) and activates ERK1/2 phosphorylation. The function of IL-34 overlaps with CSF-1 to regulate myeloid lineage differentiation, proliferation, and survival. Elevated levels of IL-34 are seen in the plasma of rheumatoid arthritis patients, but can be decreased in response to therapy. IL-34 levels are also increased in the serum of cancer patients and associated with poor prognosis. Mouse IL-34 shares 71 % sequence identity with human IL-34 on the amino acid level.
Pathways RTK Signaling

Application Details

Product Details anti-IL34 Antibody Target Details IL34 Handling References for anti-IL34 Antibody (ABIN2660791) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IL34 Antibody Target Details IL34 Application Details References for anti-IL34 Antibody (ABIN2660791) Images back to top
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-IL34 Antibody (ABIN2660791)

Product Details anti-IL34 Antibody Target Details IL34 Application Details Handling Images back to top
Background publications

Eda, Shimada, Beidler, Monahan: "Proinflammatory cytokines, IL-1β and TNF-α, induce expression of interleukin-34 mRNA via JNK- and p44/42 MAPK-NF-κB pathway but not p38 pathway in osteoblasts." in: Rheumatology international, Vol. 31, Issue 11, pp. 1525-30, 2011

Chihara, Suzu, Hassan, Chutiwitoonchai, Hiyoshi, Motoyoshi, Kimura, Okada: "IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation." in: Cell death and differentiation, Vol. 17, Issue 12, pp. 1917-27, 2010

Covaleda, Fuller, Payne: "EIAV S2 enhances pro-inflammatory cytokine and chemokine response in infected macrophages." in: Virology, Vol. 397, Issue 1, pp. 217-23, 2010

Wei, Nandi, Chitu, Yeung, Yu, Huang, Williams, Lin, Stanley: "Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells." in: Journal of leukocyte biology, Vol. 88, Issue 3, pp. 495-505, 2010

Lin, Lee, Hestir, Leo, Huang, Bosch, Halenbeck, Wu, Zhou, Behrens, Hollenbaugh, Linnemann, Qin, Wong, Chu, Doberstein, Williams: "Discovery of a cytokine and its receptor by functional screening of the extracellular proteome." in: Science (New York, N.Y.), Vol. 320, Issue 5877, pp. 807-11, 2008

Images

Product Details anti-IL34 Antibody Target Details IL34 Application Details Handling References for anti-IL34 Antibody (ABIN2660791) back to top
Supplier Images
ELISA image for anti-IL34 antibody (Interleukin 34)  (Biotin) (ABIN2660791) anti-Interleukin 34 (IL34) antibody (Biotin)