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Human IL34 Protein expressed in CHO Cells - ABIN2666711
Chen, Buki, Vääräniemi, Gu, Väänänen: The critical role of IL-34 in osteoclastogenesis. in PLoS ONE 2011
Show all 6 references for ABIN2666711
Mouse (Murine) IL34 Protein expressed in CHO Cells - ABIN2666972
Lin, Lee, Hestir, Leo, Huang, Bosch, Halenbeck, Wu, Zhou, Behrens, Hollenbaugh, Linnemann, Qin, Wong, Chu, Doberstein, Williams: Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. in Science (New York, N.Y.) 2008
Show all 5 references for ABIN2666972
Human IL34 Protein expressed in CHO Cells - ABIN2666979
Chihara, Suzu, Hassan, Chutiwitoonchai, Hiyoshi, Motoyoshi, Kimura, Okada: IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation. in Cell death and differentiation 2010
Show all 5 references for ABIN2666979
Mouse (Murine) IL34 Protein expressed in CHO Cells - ABIN2666664
Covaleda, Fuller, Payne: EIAV S2 enhances pro-inflammatory cytokine and chemokine response in infected macrophages. in Virology 2010
Show all 4 references for ABIN2666664
Human IL34 Protein expressed in Escherichia coli (E. coli) - ABIN1098782
Wang, Szretter, Vermi, Gilfillan, Rossini, Cella, Barrow, Diamond, Colonna: IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. in Nature immunology 2012
Show all 2 references for ABIN1098782
miR (show MLXIP Proteins)-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis
findings demonstrated that M-CSF (show CSF1 Proteins) binds to IL-34; molecular docking studies predicted the formation of a heteromeric M-CSF (show CSF1 Proteins)/IL-34 cytokine
These results suggest that IL-34, a novel osteoclastogenic cytokine, plays a role in rheumatoid arthritis-associated joint damage and is a potential biomarker for predicting subsequent radiographic progression in patients with RA.
IL-34 is expressed by human FOXP3 (show FOXP3 Proteins)+CD45RCloCD8+ and CD4 (show CD4 Proteins)+ Tregs and markedly inhibited alloreactive immune responses.
This paper provides evidence of alternative binding of IL-34 to chondroitin sulphates and syndecan-1 (show SDC1 Proteins) at the cell surface that modulates M-CSFR (show CSF1R Proteins) activation.
In vitro and in vivo experiments indicate that IL-34 expression is regulated by TNF-a (show TNF Proteins) and IL-1b (show IL1B Proteins) and that its overexpression is associated with an increase in osteosarcoma growth and metastasis.
the expression pattern of IL-34 in ileum and colon and suggest IL-34 as a new modulator of inflammation in inflammatory bowel disease
IL-34 is up-regulated in inflammatory bowel disease and suggest a role for this cytokine in sustaining the inflammatory responses in this disease
IL-34 is induced by IL-22 (show IL22 Proteins) in the inflammatory cascade in response to IAV infection.
IL-34 expression in human gingival fibroblasts, stimulated by TNF-alpha (show TNF Proteins) and IL-1beta (show IL1B Proteins)
study concludes that Langerhans cells require IL-34 when residing in fully differentiated and anatomically intact skin epidermis, but rely on neutrophil-derived CSF1 (show CSF1 Proteins) during inflammation
constitutive IL-34 expressed by skin keratinocytes might suppress resident macrophage responses to C. albicans colonisation by maintaining low levels TLR2 and Dectin-1 (show CLEC7A Proteins) expression by macrophages.
IL-34 protected blood-brain barrier integrity by restored expression levels of tight junction proteins, which were downregulated by pro-inflammatory cytokines.
IL-34-dependent, Mo-mediated, CSF-1 (show CSF1 Proteins) nonredundant mechanisms promote persistent ischemia-incited AKI that worsens subsequent CKD.
Tumor necrosis factor-alpha (show TNF Proteins) induces IL-34 expression via NF-kappaB (show NFKB1 Proteins) in MC3T3-E1 osteoblastic cells.
These findings suggest that TGF-beta (show TGFB1 Proteins) produced by IL-34-treated microglia is a negative regulator of microglial proliferation and enhances the neuroprotective property of microglia.
Differentiated signaling between IL-34 and CSF-1 (show CSF1 Proteins) is likely achieved by the relative thermodynamic independence of IL-34 versus negative cooperativity of CSF-1 (show CSF1 Proteins) at the CSF-1 receptor (show CSF1R Proteins) recognition sites.
IL-34 as a nonredundant cytokine for the development of Langerhans cells during embryogenesis as well as for their homeostasis in the adult skin.
Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R\; MIM 164770) (Lin et al., 2008