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both BIM (show BCL2L11 Proteins) and BCL2 (show BCL2 Proteins) proteins are regulated by LMTK2 in a GSK3beta- and PP1A (show PPP1CA Proteins)-dependent manner.
Mutation of the di-acidic export motif led to endoplasmic reticulum retention of LMTK2, and an increase in protein half-life.
Lemur Tyrosine Kinase-2 (LMTK2), negatively regulates androgen-dependent and androgen-independent prostate cancer cell proliferation. In addition, LMTK2 also negatively regulates the androgen receptor (show AR Proteins) transcriptional activity.
Data indicate that Lemur tyrosine kinase 2 (LMTK2) localizes at the plasma membrane and co-immunoprecipitates with cystic fibrosis transmembrane conductance regulator (CFTR (show CFTR Proteins)) in airway epithelial cells.
The results indicate that lemur tyrosine kinase 2 is an integral membrane protein in which both the amino and carboxyl termini are exposed to the cytoplasm. Moreover, this topology places the kinase active site within the cytoplasm.
We describe a new signalling pathway within the nervous system that links cdk5 (show CDK5 Proteins)/p35 (show ANXA1 Proteins) with phosphatase-1C and which has implications for a number of neuronal functions and neuronal dysfunction
Low LMTK2 expression is associated with the development of prostate cancer.
Data show that downregulation of myosin VI (show MYO6 Proteins) expression results in a significant reduction in PSA (show PLAG1 Proteins) and VEGF (show VEGFA Proteins) secretion in LNCaP cells, and the intracellular targeting seems to involve myosin VI (show MYO6 Proteins)-interacting proteins, GIPC (show GIPC1 Proteins) and LMTK2 and Dab2 (show DAB2 Proteins).
KPI-2 is a kinase with sites to associate with PP1C and Inh2 to form a regulatory complex that is localized to membranes
Cprk is expressed in a number of tissues but is enriched in brain and muscle; Cprk displays catalytic activity in kinase assays and is itself phosphorylated by cdk5 (show CDK5 Proteins)/p35 (show ANXA1 Proteins); Cdk5 (show CDK5 Proteins)/p35 (show ANXA1 Proteins) inhibits cprk activity
The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.
, apoptosis-associated tyrosine kinase 2
, brain-enriched kinase
, cyclin-dependent kinase 5/p35-regulated kinase
, kinase phosphatase inhibitor 2
, kinase/phosphatase/inhibitor 2
, serine/threonine-protein kinase KPI-2
, serine/threonine-protein kinase LMTK2