Browse our LMTK2 Proteins (LMTK2)

Full name:
Lemur tyrosine Kinase 2 Proteins (LMTK2)
On are 6 Lemur tyrosine Kinase 2 (LMTK2) Proteins from 3 different suppliers available. Additionally we are shipping LMTK2 Antibodies (67) and LMTK2 Kits (1) and many more products for this protein. A total of 80 LMTK2 products are currently listed.
2900041G10Rik, A330101P12Rik, aatyk2, BREK, cprk, KPI-2, KPI2, LMR2
list all proteins Gene Name GeneID UniProt
LMTK2 22853 Q8IWU2
LMTK2 231876 Q3TYD6
Rat LMTK2 LMTK2 304286  

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Human Lemur tyrosine Kinase 2 (LMTK2) interaction partners

  1. Mutation of the di-acidic export motif led to endoplasmic reticulum retention of LMTK2, and an increase in protein half-life.

  2. Lemur Tyrosine Kinase-2 (LMTK2), negatively regulates androgen-dependent and androgen-independent prostate cancer cell proliferation. In addition, LMTK2 also negatively regulates the androgen receptor (show AR Proteins) transcriptional activity.

  3. Data indicate that Lemur tyrosine kinase 2 (LMTK2) localizes at the plasma membrane and co-immunoprecipitates with cystic fibrosis transmembrane conductance regulator (CFTR (show CFTR Proteins)) in airway epithelial cells.

  4. The results indicate that lemur tyrosine kinase 2 is an integral membrane protein in which both the amino and carboxyl termini are exposed to the cytoplasm. Moreover, this topology places the kinase active site within the cytoplasm.

  5. We describe a new signalling pathway within the nervous system that links cdk5 (show CDK5 Proteins)/p35 (show ANXA1 Proteins) with phosphatase-1C and which has implications for a number of neuronal functions and neuronal dysfunction

  6. Low LMTK2 expression is associated with the development of prostate cancer.

  7. Data show that downregulation of myosin VI (show MYO6 Proteins) expression results in a significant reduction in PSA (show PLAG1 Proteins) and VEGF (show VEGFA Proteins) secretion in LNCaP cells, and the intracellular targeting seems to involve myosin VI (show MYO6 Proteins)-interacting proteins, GIPC (show GIPC1 Proteins) and LMTK2 and Dab2 (show DAB2 Proteins).

  8. KPI-2 is a kinase with sites to associate with PP1C and Inh2 to form a regulatory complex that is localized to membranes

  9. Cprk is expressed in a number of tissues but is enriched in brain and muscle; Cprk displays catalytic activity in kinase assays and is itself phosphorylated by cdk5 (show CDK5 Proteins)/p35 (show ANXA1 Proteins); Cdk5 (show CDK5 Proteins)/p35 (show ANXA1 Proteins) inhibits cprk activity

  10. BREK, Brain Enriched Kinase, is a new member of the family of protein serine/threonine kinases; plays important roles in NGF (show NGFB Proteins)-TrkA (show NTRK1 Proteins) signalling in the brain [BREK]

LMTK2 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.

Alternative names and synonyms associated with LMTK2

  • lemur tyrosine kinase 2 (LMTK2)
  • lemur tyrosine kinase 2 (Lmtk2)
  • 2900041G10Rik protein
  • A330101P12Rik protein
  • aatyk2 protein
  • BREK protein
  • cprk protein
  • KPI-2 protein
  • KPI2 protein
  • LMR2 protein

Protein level used designations for LMTK2

CDK5/p35-regulated kinase , apoptosis-associated tyrosine kinase 2 , brain-enriched kinase , cyclin-dependent kinase 5/p35-regulated kinase , hBREK , kinase phosphatase inhibitor 2 , kinase/phosphatase/inhibitor 2 , serine/threonine-protein kinase KPI-2 , serine/threonine-protein kinase LMTK2

22853 Homo sapiens
231876 Mus musculus
304286 Rattus norvegicus
608946 Canis lupus familiaris
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