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|Antigen||Leukocyte Receptor tyrosine Kinase (LTK) Antibodies|
|Epitope||AA 800-864 Alternatives|
|Conjugate||This LTK antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-LTK AntibodyTarget Details LTK Application Details Handling Images
|Specificity||This antibody recognizes Leukocyte Protein Tyrosine Kinase LTK.|
|Cross-Reactivity (Details)||Species reactivity (tested):Human.|
|Purification||Protein G Chromatography.|
|Immunogen||Synthetic peptide corresponding to a portion of amino acids 800-864 of Human LTK.|
Target Details LTKProduct Details anti-LTK Antibody Application Details Handling Images back to top
|Alternative Name||LTK / TYK1 (LTK Antibody Abstract)|
|Background||Leukocyte tyrosine kinase (LTK) is a receptor-type protein tyrosine kinase, belonging to the insulin receptor superfamily, and is mainly expressed in B lymphocyte precursors and neuronal tissues. LTK utilizes insulin receptor substrate-1 (IRS-1) and Shc as major two substrates and possesses two NPXY motifs for them separately, tyrosine 485 of one NPXY motif at the juxtamembrane domain for IRS-1 and tyrosine 862 of another NPXY motif at the carboxyl-terminal domain for Shc. It has also been shown that p85 subunit of PI3 kinase directly binds to tyrosine 753 of LTK, which is located within a YXXM motif. Tyrosine 485 and 753 are responsible for IRS-1 and PI3K mediated survival effects of LTK, respectively.Synonyms: Leukocyte tyrosine kinase receptor, Protein tyrosine kinase 1|
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Immunohistochemistry on Paraffin Sections: 10 μg/mL. Western blot: 0.5-2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-LTK Antibody Target Details LTK Application Details Images back to top
|Buffer||PBS containing 0.2 % Gelatin as stabilizer and 0.05 % Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
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