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discovered a novel signalling pathway in neural crest cell development and demonstrated fate specification of iridophores as the first identified role for Ltk
Data show FAM150B, which was named as augmentor-alpha (AUG-alpha), binds and activtes both anaplastic lymphoma kinase (ALK) and tyrosine kinase (show TXK Proteins) (LTK).
Only two related secreted factors, FAM150A and FAM150B (family with sequence similarity 150 member A and member B), stimulated LTK phosphorylation.
aberrant activation of LTK may contribute to neoplastic cell growth.
polymorphic LTKs cause up-regulation of the PI3K (show PIK3CA Proteins) pathway and possibly form one genetic component of susceptibility to abnormal proliferation of self-reactive B cells in systemic lupus erythematosus
In hippocampus, Ltk and Alk (anaplastic lymphoma kinase) are expressed throughout dentate gyrus, CA1, and CA3. Data suggest genetic interactions between Ltk and Alk in neurogenesis and behavioral measures (i.e., activity, anxiety, spatial memory).
polymorphic LTKs cause up-regulation of the PI3K pathway and possibly form one genetic component of susceptibility to abnormal proliferation of self-reactive B cells in systemic lupus erythematosus
LAR (show PTPRF Proteins) regulates Fyn (show FYN Proteins)/JAK2 (show JAK2 Proteins)/STAT3 (show STAT3 Proteins) and Fyn (show FYN Proteins)/p38 MAPK (show MAPK14 Proteins) pathways involved in ROS (show ROS1 Proteins)-induced apoptosis
Translation initiates from a non-AUG codon (CUG) in some Ltk transcript variants.
The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.
leukocyte tyrosine kinase receptor
, leukocyte receptor tyrosine kinase
, leukocyte tyrosine kinase
, anaplastic lymphoma kinase
, protein tyrosine kinase 1