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anti-Human MCK10 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended MCK10 Antibody (supplied by: Log in to see )

Antigen
Discoidin Domain Receptor Family, Member 1 (DDR1) Antibodies
  • 6030432F18
  • AI323681
  • CAK
  • Cak
  • CD167
  • CD167a
  • DDR
  • DDR1
  • Drd1
  • EDDR1
  • HGK2
  • MCK10
  • Nep
  • NEP
  • NTRK4
  • PTK3
  • PTK3A
  • PTK3D
  • RTK6
  • TRKE
Epitope
N-Term
5
1
1
1
1
1
1
Reactivity
Human
16
6
6
Host
Rabbit
11
5
Clonality
Polyclonal
Conjugate
This MCK10 antibody is un-conjugated
2
1
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
9
4
3
3
2
1
1
1
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Catalog No. ABIN359897
$ 401.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008982679 ABIN359899 EIA IHC (p) WB Rabbit Ig Log in to see Polyclonal 5
0.0008982679 ABIN614409 EIA IHC (p) WB Mouse IgG1 AA 602-681 Log in to see 2G4E12
0.0008982679 ABIN302391 IHC (p) Rabbit C-Term Log in to see Polyclonal
0.0008982679 ABIN302427 IHC (p) Rabbit N-Term Log in to see Polyclonal

Top referenced anti-MCK10 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Similar anti-MCK10 Antibodies

Application / Reactivity Human
ELISA 2 Antibodies
Enzyme Immunoassay (EIA) 4 Antibodies
Flow Cytometry (FACS) 4 Antibodies
Immunofluorescence (IF) 1 Antibodies
Immunohistochemistry (IHC) 1 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 5 Antibodies
Immunoprecipitation (IP) 1 Antibodies
Western Blotting (WB) 10 Antibodies

General

Antigen Discoidin Domain Receptor Family, Member 1 (DDR1) Antibodies
Epitope N-Term
(5), (1), (1), (1), (1), (1), (1)
Reactivity Human
(16), (6), (6)
Host Rabbit
(11), (5)
Clonality
Polyclonal
Conjugate This MCK10 antibody is un-conjugated
(2), (1), (1)
Application Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(9), (4), (3), (3), (2), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-MCK10 Antibody

Target Details MCK10 Application Details Handling References for anti-MCK10 Antibody (ABIN359897) Images
Specificity This antibody reacts to DDR1.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MCK10.
Isotype Ig

Target Details MCK10

Product Details anti-MCK10 Antibody Application Details Handling References for anti-MCK10 Antibody (ABIN359897) Images back to top
Antigen
Alternative Name CD167a / DDR1 (DDR1 Antibody Abstract)
Background Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. MCK10 is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. The gene is located on chromosome 6p21.3 in proximity to several HLA class I genes.Synonyms: CAK, CD167 antigen-like family member A, EDDR1, Epithelial discoidin domain receptor 1, Epithelial discoidin domain-containing receptor 1, MCK10, NEP, NTRK4, PTK3A, RTK6, TRKE, Tyrosine kinase DDR-1
Gene ID 780, 9606
UniProt Q08345
Pathways RTK Signaling

Application Details

Product Details anti-MCK10 Antibody Target Details MCK10 Handling References for anti-MCK10 Antibody (ABIN359897) Images back to top
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-MCK10 Antibody Target Details MCK10 Application Details References for anti-MCK10 Antibody (ABIN359897) Images back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

References for anti-MCK10 Antibody (ABIN359897)

Product Details anti-MCK10 Antibody Target Details MCK10 Application Details Handling Images back to top
Background publications

Vogel, Gish, Alves, Pawson: "The discoidin domain receptor tyrosine kinases are activated by collagen." in: Molecular cell, Vol. 1, Issue 1, pp. 13-23, 1998

Ghauri, Chapman, Meldrum: "Convulsant and anticonvulsant actions of agonists and antagonists of group III mGluRs." in: Neuroreport, Vol. 7, Issue 9, pp. 1469-74, 1997

Playford, Butler, Wang, Katso, Cooke, Ganesan: "The genomic structure of discoidin receptor tyrosine kinase." in: Genome research, Vol. 6, Issue 7, pp. 620-7, 1996

Valent, Meddeb, Danglot, Duverger, Nguyen, Bernheim: "Assignment of the NTRK4 (trkE) gene to chromosome 6p21." in: Human genetics, Vol. 98, Issue 1, pp. 12-5, 1996

Edelhoff, Sweetser, Disteche: "Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C." in: Genomics, Vol. 25, Issue 1, pp. 309-11, 1995

Images

Product Details anti-MCK10 Antibody Target Details MCK10 Application Details Handling References for anti-MCK10 Antibody (ABIN359897) back to top
Supplier Images
 image for anti-MCK10 antibody (Discoidin Domain Receptor Family, Member 1) (N-Term) (ABIN359897) anti-Discoidin Domain Receptor Family, Member 1 (DDR1) (N-Term) antibody
 image for anti-MCK10 antibody (Discoidin Domain Receptor Family, Member 1) (N-Term) (ABIN359897) anti-Discoidin Domain Receptor Family, Member 1 (DDR1) (N-Term) antibody (Image 2)