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|Antigen||Discoidin Domain Receptor Family, Member 1 (DDR1) Antibodies|
|Conjugate||This MCK10 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-MCK10 AntibodyTarget Details MCK10 Application Details Handling References for anti-MCK10 antibody (ABIN359899) Images
|Specificity||This antibody reacts to MCK10.|
|Purification||Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with recombinant human MCK10 protein.|
Target Details MCK10Product Details anti-MCK10 Antibody Application Details Handling References for anti-MCK10 antibody (ABIN359899) Images back to top
|Alternative Name||CD167a / DDR1 (DDR1 Antibody Abstract)|
|Background||Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. MCK10 is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain.Synonyms: CAK, CD167 antigen-like family member A, EDDR1, Epithelial discoidin domain receptor 1, Epithelial discoidin domain-containing receptor 1, MCK10, NEP, NTRK4, PTK3A, RTK6, TRKE, Tyrosine kinase DDR-1|
|Gene ID||780, 9606|
|Pathways||RTK Signaling, Smooth Muscle Cell Migration|
Application DetailsProduct Details anti-MCK10 Antibody Target Details MCK10 Handling References for anti-MCK10 antibody (ABIN359899) Images back to top
ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MCK10 Antibody Target Details MCK10 Application Details References for anti-MCK10 antibody (ABIN359899) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-MCK10 antibody (ABIN359899)Product Details anti-MCK10 Antibody Target Details MCK10 Application Details Handling Images back to top
Vogel, Gish, Alves, Pawson: "The discoidin domain receptor tyrosine kinases are activated by collagen." in: Molecular cell, Vol. 1, Issue 1, pp. 13-23, 1998
Ghauri, Chapman, Meldrum: "Convulsant and anticonvulsant actions of agonists and antagonists of group III mGluRs." in: Neuroreport, Vol. 7, Issue 9, pp. 1469-74, 1997
Playford, Butler, Wang, Katso, Cooke, Ganesan: "The genomic structure of discoidin receptor tyrosine kinase." in: Genome research, Vol. 6, Issue 7, pp. 620-7, 1996
Valent, Meddeb, Danglot, Duverger, Nguyen, Bernheim: "Assignment of the NTRK4 (trkE) gene to chromosome 6p21." in: Human genetics, Vol. 98, Issue 1, pp. 12-5, 1996
Edelhoff, Sweetser, Disteche: "Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C." in: Genomics, Vol. 25, Issue 1, pp. 309-11, 1995
ImagesProduct Details anti-MCK10 Antibody Target Details MCK10 Application Details Handling References for anti-MCK10 antibody (ABIN359899) back to top