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Browse our MDK Proteins (MDK)

Full name:
Midkine (Neurite Growth-Promoting Factor 2) Proteins (MDK)
On are 41 Midkine (Neurite Growth-Promoting Factor 2) (MDK) Proteins from 15 different suppliers available. Additionally we are shipping MDK Antibodies (145) and MDK Kits (44) and many more products for this protein. A total of 241 MDK products are currently listed.
ARAP, mdk, Mek, midkine, MK, MK-B, NEGF2, PTF-alpha-1, RIHB
list all proteins Gene Name GeneID UniProt
MDK 17242 P12025
MDK 81517 Q9R1S9
MDK 4192 P21741

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MDK Proteins (MDK) by Origin

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Top referenced MDK Proteins

  1. Human MDK Protein expressed in Escherichia coli (E. coli) - ABIN666781 : Jin, Lahat, Korchin, Nguyen, Zhu, Wang, Lazar, Trent, Pollock, Lev: Midkine enhances soft-tissue sarcoma growth: a possible novel therapeutic target. in Clinical cancer research : an official journal of the American Association for Cancer Research 2008 (PubMed)
    Show all 2 references for ABIN666781

  2. Human MDK Protein expressed in Baculovirus infected Insect Cells - ABIN2002427 : Murasugi, Tohma-Aiba: Characterization of partially truncated human midkine expressed in Pichia pastoris. in Bioscience, biotechnology, and biochemistry 2002 (PubMed)

More Proteins for MDK Interaction Partners

Mouse (Murine) Midkine (Neurite Growth-Promoting Factor 2) (MDK) interaction partners

  1. Ethanol engages MDK (and ALK) signaling, which has important consequences for alcohol-induced neurotoxicity.

  2. Mdk plays a crucial role in the early inflammation phase and during the development of cartilaginous callus in the fracture healing process.

  3. This study demonistrated that a differential regulation of specific behavioural responses to ethanol by midkine.

  4. clonidine-induced analgesia was significantly enhanced in PTN (show PTN Proteins)-/- mice compared to MK-/- and WT+/+ mice in the tail-immersion test

  5. midkine plays a critical role in cardiac hypertrophy and remodelling.

  6. Midkine exerts a neuroprotective role against amphetamine-induced neurotoxicity in striatum.

  7. MK leads to a blockade of PAI-1 (show SERPINE1 Proteins), which is closely associated with the suppression of crescentic glomerulonephritis.

  8. Findings indicate a critical role for the midkine-Notch2 (show NOTCH2 Proteins) signaling axis in neuroblastoma (show ARHGEF16 Proteins) tumorigenesis, which implicates new strategies to treat neuroblastoma (show ARHGEF16 Proteins).

  9. This study concluded that MEK is essential for acquisition of gliogenic competence by radial progenitors and that levels of MEK activity regulate gliogenesis in the developing cortex.

  10. Identify endothelial cells as the source of soluble midkine in the vascular system during hypoxia and defined midkine as a pivotal player of angiogenesis during ischemia in nonmalignant tissue.

Human Midkine (Neurite Growth-Promoting Factor 2) (MDK) interaction partners

  1. MDK plays an important role in non-small cell lung cancer progression and prognosis and may act as a convincing prognostic indicator for non-small cell lung cancer patients.

  2. The concentration of MDK in amniotic fluid declined with gestational age.MDK concentrations in amniotic fluid were far higher than in maternal plasma.

  3. The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture.

  4. overexpression of midkine protein serves as an unfavorable prognostic biomarker in breast cancer patients

  5. our results suggest that midkine expression could be a clinically useful marker in predicting the presence of multiple lymph node metastases in BRAFV600E papillary thyroid carcinoma.

  6. PLSCR1 (show PLSCR1 Proteins) positively regulates hepatic carcinoma cell proliferation and migration through interacting with midkine

  7. Use hybrid-type modified chitosan derivative nanoparticles to deliver midkine-siRNA to HepG2 cells.

  8. SP1 (show PSG1 Proteins) directly up-regulated the expression of midkine (MDK), and the SP1 (show PSG1 Proteins)-MDK axis cooperated in glioma tumorigenesis.

  9. Results from targeted sequencing in patients with acute lymphoblastic leukemia identified KMT2D and KIF1B as novel putative driver genes and a putative regulatory non-coding variant that coincided with overexpression of the growth factor MDK.

  10. MK expression in glioma was higher than in paratumor tissues. Overexpression was associated with the WHO grade, low Karnofsky score, time to recurrence, and poor survival. Co-expression of pleiotrophin (show PTN Proteins) and MK had a worse prognosis than either alone.

Cow (Bovine) Midkine (Neurite Growth-Promoting Factor 2) (MDK) interaction partners

  1. Data show that 9-cis-retinoic acid enhanced midkine gene expression, but not insulin-like growth factor-I (show IGF1 Proteins) gene expression, in cumulus-granulosa cells.

Rabbit Midkine (Neurite Growth-Promoting Factor 2) (MDK) interaction partners

  1. Found that macrophages are the major source of midkine in the atherosclerotic neointima of in-stent restenosis in hypercholesterolemic rabbits.

Pig (Porcine) Midkine (Neurite Growth-Promoting Factor 2) (MDK) interaction partners

  1. MK is able to maintain a proliferative PGC (show PGC Proteins) phenotype mediated by the suppression of DAZL (show DAZL Proteins) in early germ cells

MDK Protein Profile

Protein Summary

This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed.

Alternative names and synonyms associated with MDK

  • midkine (neurite growth-promoting factor 2) (mdk-b)
  • midkine (Mdk)
  • midkine (neurite growth-promoting factor 2) (MDK)
  • midkine (neurite growth-promoting factor 2) (Mdk)
  • ARAP protein
  • mdk protein
  • Mek protein
  • midkine protein
  • MK protein
  • MK-B protein
  • NEGF2 protein
  • PTF-alpha-1 protein
  • RIHB protein

Protein level used designations for MDK

PTF-alpha-2 , X-PTF-alpha2 , midkine-B , pleiotrophic factor-alpha-2 , pleiotrophic factor-alpha2 , retinoic acid-induced differentiation factor , MK , amphiregulin-associated protein , midgestation and kidney protein , midkine , neurite outgrowth-promoting factor 2 , retinoic acid inducible factor , RI-HB , retinoic acid-induced heparin-binding protein

399256 Xenopus laevis
17242 Mus musculus
81517 Rattus norvegicus
4192 Homo sapiens
280852 Bos taurus
100008929 Oryctolagus cuniculus
100713073 Cavia porcellus
100359358 Sus scrofa
423196 Gallus gallus
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