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Analyses of the melanoma secretome and validation in clinical specimens showed that the heparin-binding factor (show PTN Proteins) midkine is a systemic inducer of neo-lymphangiogenesis that defines patient prognosis. This role of midkine was linked to a paracrine activation of the mTOR (show FRAP1 Proteins) pathway in lymphatic endothelial cells.
MK serves an indispensable role in the NFAT (show NFATC1 Proteins)-regulated activation of CD4 (show CD4 Proteins)(+) T cells and Th1 (show HAND1 Proteins) cell differentiation.
Ethanol engages MDK (and ALK) signaling, which has important consequences for alcohol-induced neurotoxicity.
Mdk plays a crucial role in the early inflammation phase and during the development of cartilaginous callus in the fracture healing process.
This study demonistrated that a differential regulation of specific behavioural responses to ethanol by midkine.
clonidine-induced analgesia was significantly enhanced in PTN (show PTN Proteins)-/- mice compared to MK-/- and WT+/+ mice in the tail-immersion test
midkine plays a critical role in cardiac hypertrophy and remodelling.
Midkine exerts a neuroprotective role against amphetamine-induced neurotoxicity in striatum.
MK leads to a blockade of PAI-1 (show SERPINE1 Proteins), which is closely associated with the suppression of crescentic glomerulonephritis.
Findings indicate a critical role for the midkine-Notch2 (show NOTCH2 Proteins) signaling axis in neuroblastoma (show ARHGEF16 Proteins) tumorigenesis, which implicates new strategies to treat neuroblastoma (show ARHGEF16 Proteins).
Data suggest that mature KLK9 (kallikrein 9 (show KLK9 Proteins)) is a glycosylated chymotrypsin-like enzyme with strong preference for tyrosine over phenylalanine at P1 cleavage position; substrate specificity of KLK9 (show KLK9 Proteins) appears to extend to KLK10 (show KLK10 Proteins) and midkine; enzyme activity is enhanced by Mg2 (show MUC7 Proteins)+ and Ca2 (show CA2 Proteins)+, but is reversibly attenuated by Zn2+; KLK9 (show KLK9 Proteins) is inhibited in vitro by many naturally occurring or synthetic protease inhibitors.
midkine may be a good inflammatory marker in renal transplant recipients as in other inflammatory diseases. Moreover, it seems that it is not affected by factors other than inflammation during the post-transplantation period.
MDK plays an important role in non-small cell lung cancer progression and prognosis and may act as a convincing prognostic indicator for non-small cell lung cancer patients.
The concentration of MDK in amniotic fluid declined with gestational age.MDK concentrations in amniotic fluid were far higher than in maternal plasma.
The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture.
overexpression of midkine protein serves as an unfavorable prognostic biomarker in breast cancer patients
our results suggest that midkine expression could be a clinically useful marker in predicting the presence of multiple lymph node metastases in BRAFV600E papillary thyroid carcinoma.
PLSCR1 (show PLSCR1 Proteins) positively regulates hepatic carcinoma cell proliferation and migration through interacting with midkine
Use hybrid-type modified chitosan derivative nanoparticles to deliver midkine-siRNA to HepG2 cells.
SP1 (show PSG1 Proteins) directly up-regulated the expression of midkine (MDK), and the SP1 (show PSG1 Proteins)-MDK axis cooperated in glioma tumorigenesis.
Data show that 9-cis-retinoic acid enhanced midkine gene expression, but not insulin-like growth factor-I (show IGF1 Proteins) gene expression, in cumulus-granulosa cells.
Found that macrophages are the major source of midkine in the atherosclerotic neointima of in-stent restenosis in hypercholesterolemic rabbits.
MK is able to maintain a proliferative PGC (show PGC Proteins) phenotype mediated by the suppression of DAZL (show DAZL Proteins) in early germ cells
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
, pleiotrophic factor-alpha-2
, pleiotrophic factor-alpha2
, retinoic acid-induced differentiation factor
, amphiregulin-associated protein
, midgestation and kidney protein
, neurite outgrowth-promoting factor 2
, retinoic acid inducible factor
, retinoic acid-induced heparin-binding protein