Browse our anti-MERTK (MERTK) Antibodies

On www.antibodies-online.com are 213 C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) Antibodies from 27 different suppliers available. Additionally we are shipping MERTK Proteins (25) and MERTK Kits (22) and many more products for this protein. A total of 277 MERTK products are currently listed.
Synonyms:
C-EYK, c-mer, DKFZp469D2215, Eyk, Mer, MERTK, nmf12, Nyk, rdy, RP38, si:ch1073-268l12.2
list all antibodies Gene Name GeneID UniProt
MERTK 10461 Q12866
MERTK 17289 Q60805
MERTK 65037 P57097

Most Popular Reactivities for anti-MERTK (MERTK) Antibodies

anti-Human MERTK Antibodies:

anti-Mouse (Murine) MERTK Antibodies:

anti-Rat (Rattus) MERTK Antibodies:

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More Antibodies against MERTK Interaction Partners

Human C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) interaction partners

  1. Patients with macroalbuminuria diabetes had higher circulating levels of sMer and more urinary soluble Tyro3 (show TYRO3 Antibodies) and sMer than normoalbuminuric diabetics. Increased clearance of sTyro3 and sMer was associated with loss of tubular Tyro3 (show TYRO3 Antibodies) and Mer expression in diabetic nephropathy tissue. During in vitro diabetes, human kidney cells had down-regulation of Tyro3 (show TYRO3 Antibodies) and Mer mRNA and increased shedding of sTyro3 and sMer.

  2. evidence that proteolytic cleavage of the macrophage efferocytosis receptor c-Mer tyrosine kinase (show TXK Antibodies) (MerTK) reduces efferocytosis and promotes plaque necrosis and defective resolution.

  3. Small molecule and antibody inhibitors of AXL (show AXL Antibodies) and MER have recently been described, and some of these have already entered clinical trials. The optimal design of treatment strategies to maximize the clinical benefit of these AXL (show AXL Antibodies) and MER targeting agents are discussed in relation to the different cancer types and the types of resistance encountered.

  4. A 48 bp insertion sequence was buried within the breakpoint; 18 bps shared homology to MIR4435-2HG and LINC00152, and 30 bp mapped to MERTK. The deletion cosegregated with arRP in the family.

  5. In this paper, we review the biology of the Gas6 (show GAS6 Antibodies)/Tyro3 (show TYRO3 Antibodies), Axl (show AXL Antibodies), and MerTK(collectively named TAM (show CCNA1 Antibodies) system)and the current evidence supporting its potential role in the pathogenesis of multiple sclerosis .

  6. The rs4374383 AA genotype, associated with lower intrahepatic expression of MERTK, is protective against F2-F4 fibrosis in patients with non-alcoholic fatty liver disease (NAFLD (show TSC2 Antibodies)).

  7. We report a novel missense mutation (c.3G>A, p.0?) in the MERTK gene that causes severe vision impairment in a patient.

  8. Utilizing an ex vivo co-cultivation approach to model key cellular and molecular events found in vivo during infarction, cardiomyocyte phagocytosis was found to be inefficient, in part due to myocyte-induced shedding of macrophage MERTK

  9. Upon differentiation of these iPSC towards RPE (show RPE Antibodies), patient-specific RPE (show RPE Antibodies) cells exhibited defective phagocytosis, a characteristic phenotype of MERTK deficiency observed in human patients and animal models

  10. The current study demonstrates the contribution of the TAM (show CCNA1 Antibodies) receptor MerTK to the phagocytosis of myelin by human adult microglia and monocyte-derived macrophages.

Mouse (Murine) C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) interaction partners

  1. evidence that proteolytic cleavage of the macrophage efferocytosis receptor c-Mer tyrosine kinase (show TYRO3 Antibodies) (MerTK) reduces efferocytosis and promotes plaque necrosis and defective resolution.

  2. these results suggest, for the first time, that MerTK is an intracellular negative feedback regulator that inhibits the inflammatory response of lipoteichoic acid -stimulated macrophages

  3. the reciprocal activation of Axl (show AXL Antibodies) and Mer (show ERH Antibodies) receptor tyrosine kinases has a major impact on the outcome of renal inflammation.

  4. Reduced transcription of Mertk, rather than differences in MERTK protein structure, determines the reduced efficiency of apoptotic cell clearance in the Aath4a(DBA/DBA (show RPS19 Antibodies)) mice, which, in turn, contributes to their increased susceptibility to atherosclerosis.

  5. Axl (show AXL Antibodies), Mertk and Tyro3 (show TYRO3 Antibodies) receptors are not required for Zika virus entry and infection.

  6. Signaling through the Mer (show ERH Antibodies) proto-oncogene (show RAB1A Antibodies) tyrosine kinase (show TYRO3 Antibodies) (MerTK) receptor in cultured macrophages and in sterile inflammation in vivo promotes specialized proresolving mediator (SPM (show NPC1 Antibodies)) biosynthesis by a mechanism involving an increase in the cytoplasmic:nuclear ratio of a key SPM (show NPC1 Antibodies) biosynthetic enzyme, 5-lipoxygenase (show ALOX5 Antibodies).

  7. These studies define the clearance of infected, apoptotic neutrophils by dendritic cells and Mer (show ERH Antibodies) receptor signaling as central to the early immune evasion strategies of L. major.

  8. Tyro3 (show TYRO3 Antibodies) gene dosage modulates Mertk-associated retinal degeneration, provide strong evidence for a direct role for TYRO3 (show TYRO3 Antibodies) in RPE (show RPE Antibodies) phagocytosis, and suggest that an eQTL (show EQTN Antibodies) can modify a recessive Inherited photoreceptor degenerations.

  9. Activation of Mertk synergized with interferon-beta (show IFNB1 Antibodies) to tighten cell junctions and prevent virus transit across brain microvascular endothelial cells.

  10. results establish TAM (show CCNA1 Antibodies) receptors as both controllers of microglial physiology and potential targets for therapeutic intervention in central nervous system disease

MERTK Antigen Profile

Antigen Summary

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).

Alternative names and synonyms associated with MERTK

  • c-mer proto-oncogene tyrosine kinase (MERTK) antibody
  • c-mer proto-oncogene tyrosine kinase (LOC100219161) antibody
  • c-mer proto-oncogene tyrosine kinase (mertk) antibody
  • c-mer proto-oncogene tyrosine kinase (Mertk) antibody
  • C-EYK antibody
  • c-mer antibody
  • DKFZp469D2215 antibody
  • Eyk antibody
  • Mer antibody
  • MERTK antibody
  • nmf12 antibody
  • Nyk antibody
  • rdy antibody
  • RP38 antibody
  • si:ch1073-268l12.2 antibody

Protein level used designations for MERTK

c-eyk proto-oncogene , tyrosine-protein kinase Mer , c-mer proto-oncogene tyrosine kinase , MER receptor tyrosine kinase , tyrosine-protein kinase Mer-like , STK kinase , proto-oncogene c-Mer , receptor tyrosine kinase MerTK , Tyro 12 , proto-oncogene tyrosine-protein kinase Mer , Receptor tyrosine tinase gene probably the gene for Rdy , proto-oncogene tyrosine-protein kinase MER , retinal dystrophy

GENE ID SPECIES
395836 Gallus gallus
459492 Pan troglodytes
483060 Canis lupus familiaris
504429 Bos taurus
698330 Macaca mulatta
100171862 Pongo abelii
100219161 Taeniopygia guttata
100322133 Danio rerio
100476239 Ailuropoda melanoleuca
10461 Homo sapiens
17289 Mus musculus
65037 Rattus norvegicus
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