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|Application / Reactivity||Human||Mouse (Murine)|
|Immunofluorescence (fixed cells) (IF/ICC)||1 Antibodies||1 Antibodies|
|Western Blotting (WB)||84 Antibodies||43 Antibodies|
|Neutralization (Neut)||1 Antibodies|
|Immunoprecipitation (IP)||3 Antibodies||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||29 Antibodies||19 Antibodies|
|Immunohistochemistry (IHC)||16 Antibodies||16 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||28 Antibodies||28 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies||1 Antibodies|
|Antigen||Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This MST1R antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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Product Details anti-MST1R AntibodyTarget Details MST1R Application Details Handling Images
|Specificity||This antibody is reactive with MST1R/Ron (family: protein kinase, subfamily: HGF receptor).|
|Immunogen||Synthetic peptide - KLH conjugated|
Target Details MST1RProduct Details anti-MST1R Antibody Application Details Handling Images back to top
|Alternative Name||CD136 / MST1R (MST1R Antibody Abstract)|
|Background||MST1R/Ron, a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. MST1R/Ron expression has been documented in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uterus.Synonyms: MSP receptor, Macrophage-Stimulating 1 Receptor, Macrophage-stimulating protein receptor, Macrophage-stimulating protein receptor alpha chain, Macrophage-stimulating protein receptor beta chain, PTK8, RON, p185-Ron|
Application DetailsProduct Details anti-MST1R Antibody Target Details MST1R Handling Images back to top
Immunohistochemistry on paraffin embedded sections: 4 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MST1R Antibody Target Details MST1R Application Details Images back to top
|Buffer||PBS, 0.09 % Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-80 °C|
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
|Expiry Date||12 months|
ImagesProduct Details anti-MST1R Antibody Target Details MST1R Application Details Handling back to top