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we show that stapled peptides targeting the interface between NCKAP1 and CYFIP1 (show CYFIP1 ELISA Kits) destabilize the WASF3 (show WASF3 ELISA Kits) complex... thereby suppressing invasion and metastasis of breast cancer cells.
We identify three mosaic missense and likely-gene disrupting mutations in genes previously implicated in ASD (show ARSD ELISA Kits) (KMT2C, NCKAP1, and MYH10 (show MYH10 ELISA Kits)) in probands but none in siblings. We find a strong ascertainment bias for mosaic mutations in probands relative to their unaffected siblings
miR (show MLXIP ELISA Kits)-34c-3p functions as a tumor promoter by targeting NCKAP1 that is associated with prognosis in hepatocellular carcinoma.
Nap1 is a constitutive and essential component of a WAVE2- and Abi-1-containing complex linking Rac to site-directed actin assembly.
Nap1 mutant phenotypes define the crucial roles of Nap1/WAVE-mediated actin regulation in tissue organization and establishment of the body plan of the mammalian embryo.
Inhibition of Nap1, a member of the WAVE actin-remodeling complex, results in accumulations of F-actin structures at the plasma membrane that are concomitant with a decrease in myoblast fusion.
interacts with Nck and may be involved in the downstream signaling of Nck
membrane-associated protein HEM-2
, nck-associated protein 1
, NAP 1
, brain protein H19