anti-Dog (Canine) Neuregulin 1 antibody for Western Blotting

Recommended Neuregulin 1 Antibody (supplied by: Log in to see )

Antigen
Neuregulin 1 (NRG1) Antibodies
  • NRG1
  • wu:fm70e01
  • DKFZp459A1838
  • HPRG
  • HRGP
  • THPH11
  • HRG1
  • ARIA
  • GGF
  • GGF2
  • HGL
  • HRG
  • HRGA
  • MST131
  • NDF
  • SMDF
  • 6030402G23Rik
  • D230005F13Rik
  • GGFII
  • HRGalpha
  • Hgl
  • pro-neuregulin-1
  • NRG-1
  • heregulin
  • nrg1-A
  • neuregulin 1
  • histidine-rich glycoprotein
  • NRG1
  • nrg1
  • Nrg1
  • HRG
  • Hrg
Epitope
N-Term
23
19
16
14
11
10
8
7
7
7
6
6
5
5
5
4
4
4
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Horse (Equine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus), Sheep (Ovine)
237
78
74
3
2
1
1
Host
Rabbit
201
69
Clonality
Polyclonal
Conjugate
This Neuregulin 1 antibody is un-conjugated
21
13
7
4
4
4
3
3
3
3
3
3
3
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
223
127
68
44
19
16
15
11
8
5
5
5
5
4
3
1
Options
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Catalog No. ABIN2782798
$ 289.00
Plus shipping costs $45.00

General

Antigen Neuregulin 1 (NRG1) Antibodies
Epitope N-Term
(23), (19), (16), (14), (11), (10), (8), (7), (7), (7), (6), (6), (5), (5), (5), (4), (4), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Cow (Bovine), Dog (Canine), Horse (Equine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus), Sheep (Ovine)
(237), (78), (74), (3), (2), (1), (1)
Host Rabbit
(201), (69)
Clonality
Polyclonal
Conjugate This Neuregulin 1 antibody is un-conjugated
(21), (13), (7), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Western Blotting (WB)
(223), (127), (68), (44), (19), (16), (15), (11), (8), (5), (5), (5), (5), (4), (3), (1)
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Product Details anti-Neuregulin 1 Antibody

Target Details Neuregulin 1 Application Details Handling Images
Blocking Peptide Blocking peptide for this product available: ABIN980957
Sequence YMCKVISKLG NDSASANITI VESNEIITGM PASTEGAYVS SESPIRISVS
Predicted Reactivity Cow: 93%, Dog: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 93%, Rat: 93%, Sheep: 93%
Characteristics This is a rabbit polyclonal antibody against NRG1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human NRG1

Target Details Neuregulin 1

Product Details anti-Neuregulin 1 Antibody Application Details Handling Images back to top
Antigen
Alternative Name NRG1 (NRG1 Antibody Abstract)
Background Neuregulin 1 (NRG1) interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues.Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains, and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains, and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.
Alias Symbols: ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, NDF, SMDF, MST131
Protein Interaction Partner: IKZF4, ADAM19, LIMK1, ERBB4, ERBB3, EGF, EGFR, ERBB2, DLG4,
Protein Size: 637
Molecular Weight 70 kDa
Gene ID 3084
NCBI Accession NM_013957, NP_039251
UniProt Q7RTW3
Research Area Neurology, Glia marker
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation

Application Details

Product Details anti-Neuregulin 1 Antibody Target Details Neuregulin 1 Handling Images back to top
Restrictions For Research Use only

Handling

Product Details anti-Neuregulin 1 Antibody Target Details Neuregulin 1 Application Details Images back to top
Format Liquid
Concentration 1 mg/mL
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeat freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Images

Product Details anti-Neuregulin 1 Antibody Target Details Neuregulin 1 Application Details Handling back to top
Supplier Images
Western Blotting (WB) image for anti-Neuregulin 1 (NRG1) (N-Term) antibody (ABIN2782798) NRG1 (neuregulin 1) Antibody (against the N terminal of NRG1) (50ug) validated by WB ...