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anti-Human Neuregulin 1 antibody for Enzyme Immunoassay

Recommended Neuregulin 1 Antibody (supplied by: Log in to see )

Antigen
Neuregulin 1 (NRG1) Antibodies
  • 6030402G23Rik
  • ARIA
  • D230005F13Rik
  • DKFZp459A1838
  • GGF
  • GGF2
  • GGFII
  • heregulin
  • HGL
  • Hgl
  • HPRG
  • HRG
  • HRG1
  • HRGA
  • HRGalpha
  • HRGP
  • MST131
  • NDF
  • NRG-1
  • NRG1
  • nrg1-A
  • pro-neuregulin-1
  • SMDF
  • THPH11
  • wu:fm70e01
Epitope
Middle Region
21
20
14
12
8
8
8
7
7
7
6
5
4
4
4
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
174
70
60
2
1
1
1
Host
Rabbit
191
21
Clonality
Polyclonal
Conjugate
This Neuregulin 1 antibody is un-conjugated
18
11
4
3
3
3
2
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
155
91
61
39
19
12
11
10
10
8
5
3
3
3
Supplier
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Catalog No. ABIN358711
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008833851 ABIN1108408 EIA WB Mouse IgG1 AA 20-241 Log in to see k1G13 3
0.0008833851 ABIN265466 EIA IF IHC (p) WB Rabbit Log in to see Polyclonal
0.0008833851 ABIN783139 EIA IHC (p) WB Rabbit IgG Isoform 10, N-Term Log in to see Polyclonal

Top referenced anti-Neuregulin 1 antibody for Enzyme Immunoassay

Similar anti-Neuregulin 1 Antibodies

Application / Reactivity Human
Blocking Reagent (BR) 3 Antibodies
ELISA 72 Antibodies
Enzyme Immunoassay (EIA) 4 Antibodies
Flow Cytometry (FACS) 19 Antibodies
Immunochromatography (IC) 2 Antibodies
Immunocytochemistry (ICC) 7 Antibodies
Immunofluorescence (IF) 4 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 12 Antibodies
Immunohistochemistry (IHC) 56 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 6 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 32 Antibodies
Immunoprecipitation (IP) 6 Antibodies
Neutralization (Neut) 8 Antibodies
Western Blotting (WB) 136 Antibodies

General

Antigen Neuregulin 1 (NRG1) Antibodies
Epitope Middle Region
(21), (20), (14), (12), (8), (8), (8), (7), (7), (7), (6), (5), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(174), (70), (60), (2), (1), (1), (1)
Host Rabbit
(191), (21)
Clonality
Polyclonal
Conjugate This Neuregulin 1 antibody is un-conjugated
(18), (11), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(155), (91), (61), (39), (19), (12), (11), (10), (10), (8), (5), (3), (3), (3)
Pubmed 5 references available
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Product Details anti-Neuregulin 1 Antibody

Target Details Neuregulin 1 Application Details Handling References for anti-Neuregulin 1 Antibody (ABIN358711) Images
Specificity This antibody reacts to NRG1.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human NRG1.
Isotype Ig

Target Details Neuregulin 1

Product Details anti-Neuregulin 1 Antibody Application Details Handling References for anti-Neuregulin 1 Antibody (ABIN358711) Images back to top
Antigen
Alternative Name Neuregulin 1 (NRG1 Antibody Abstract)
Background Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains, and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.Synonyms: Acetylcholine receptor-inducing activity, Breast cancer cell differentiation factor p45, GGF, Glial growth factor, HGL, HRG, HRGA, Heregulin, NDF, NRG1, Neu differentiation factor, Pro-neuregulin-1 membrane-bound isoform, SMDF, Sensory and motor neuron-derived factor
Gene ID 3084, 9606
UniProt Q02297
Research Area Growth Factors
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-Neuregulin 1 Antibody Target Details Neuregulin 1 Handling References for anti-Neuregulin 1 Antibody (ABIN358711) Images back to top
Application Notes ELISA: 1/1,000. Western Blot: 1/50 - 1/100. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-Neuregulin 1 Antibody Target Details Neuregulin 1 Application Details References for anti-Neuregulin 1 Antibody (ABIN358711) Images back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

References for anti-Neuregulin 1 Antibody (ABIN358711)

Product Details anti-Neuregulin 1 Antibody Target Details Neuregulin 1 Application Details Handling Images back to top
Background publications

Stove, Stove, Derycke, Van Marck, Mareel, Bracke: "The heregulin/human epidermal growth factor receptor as a new growth factor system in melanoma with multiple ways of deregulation." in: The Journal of investigative dermatology, Vol. 121, Issue 4, pp. 802-12, 2003

Adélaïde, Huang, Murati, Alsop, Orsetti, Mozziconacci, Popovici, Ginestier, Letessier, Basset, Courtay-Cahen, Jacquemier, Theillet, Birnbaum, Edwards, Chaffanet: "A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 gene." in: Genes, chromosomes & cancer, Vol. 37, Issue 4, pp. 333-45, 2003

Ritch, Carroll, Sontheimer: "Neuregulin-1 enhances motility and migration of human astrocytic glioma cells." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20971-8, 2003

Vermeer, Einwalter, Moninger, Rokhlina, Kern, Zabner, Welsh: "Segregation of receptor and ligand regulates activation of epithelial growth factor receptor." in: Nature, Vol. 422, Issue 6929, pp. 322-6, 2003

Atlas, Cardillo, Mehmi, Zahedkargaran, Tang, Lupu: "Heregulin is sufficient for the promotion of tumorigenicity and metastasis of breast cancer cells in vivo." in: Molecular cancer research : MCR, Vol. 1, Issue 3, pp. 165-75, 2003

Images

Product Details anti-Neuregulin 1 Antibody Target Details Neuregulin 1 Application Details Handling References for anti-Neuregulin 1 Antibody (ABIN358711) back to top
Supplier Images
 image for anti-Neuregulin 1 antibody (NRG1) (Middle Region) (ABIN358711) anti-Neuregulin 1 (NRG1) (Middle Region) antibody
 image for anti-Neuregulin 1 antibody (NRG1) (Middle Region) (ABIN358711) anti-Neuregulin 1 (NRG1) (Middle Region) antibody (Image 2)