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|Application / Reactivity||Human|
|ELISA (Capture)||1 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies|
|Immunohistochemistry (IHC)||19 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||2 Antibodies|
|Western Blotting (WB)||17 Antibodies|
|Antigen||Neuregulin 2 (NRG2) Antibodies|
|Epitope||AA 358-389, C-Term Alternatives|
|Conjugate||This Neuregulin 2 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
|5 references available|
|Supplier||Log in to see|
Product Details anti-Neuregulin 2 AntibodyTarget Details Neuregulin 2 Application Details Handling References for anti-Neuregulin 2 Antibody (ABIN1882105) Images
|Predicted Reactivity||Rat (Rattus)|
|Purification||This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Purified Rabbit Polyclonal Antibody (Pab)|
|Immunogen||This NRG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 358-389 amino acids from the C-terminal region of human NRG2.|
Target Details Neuregulin 2Product Details anti-Neuregulin 2 Antibody Application Details Handling References for anti-Neuregulin 2 Antibody (ABIN1882105) Images back to top
|Alternative Name||NRG2 (NRG2 Antibody Abstract)|
Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the Erbb family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. There are six NRG2 alternatively spliced transcripts which are variable between the epidermal growth factor-like (EGF-like) and the transmembrane domains. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease.
Synonyms: NRG2, NTAK, Pro-neuregulin-2, membrane-bound isoform, Neuregulin-2, Divergent of neuregulin-1, Neural- and thymus-derived activator for ERBB kinases
|NCBI Accession||NP_053585, NP_053584, NP_001171864, NP_053586, NP_004874|
|Research Area||Signaling, Tyrosine Kinases|
|Pathways||RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-Neuregulin 2 Antibody Target Details Neuregulin 2 Handling References for anti-Neuregulin 2 Antibody (ABIN1882105) Images back to top
|Application Notes||IHC (p): 1:50-100|
|Restrictions||For Research Use only|
HandlingProduct Details anti-Neuregulin 2 Antibody Target Details Neuregulin 2 Application Details References for anti-Neuregulin 2 Antibody (ABIN1882105) Images back to top
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.|
|Precaution of Use||WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.|
References for anti-Neuregulin 2 Antibody (ABIN1882105)Product Details anti-Neuregulin 2 Antibody Target Details Neuregulin 2 Application Details Handling Images back to top
|Product cited in:||
Yamada, Ichino, Nishii et al.: "Characterization of the human NTAK gene structure and distribution of the isoforms for rat NTAK mRNA." in: Gene, Vol. 255, Issue 1, pp. 15-24, 2000 (PubMed).
Ring, Chang, Guilbot et al.: "The human neuregulin-2 (NRG2) gene: cloning, mapping and evaluation as a candidate for the autosomal recessive form of Charcot-Marie-Tooth disease linked to 5q." in: Human genetics, Vol. 104, Issue 4, pp. 326-32, 1999 (PubMed).
Higashiyama, Horikawa, Yamada et al.: "A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4." in: Journal of biochemistry, Vol. 122, Issue 3, pp. 675-80, 1998 (PubMed).
Busfield, Michnick, Chickering et al.: "Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus." in: Molecular and cellular biology, Vol. 17, Issue 7, pp. 4007-14, 1997 (PubMed).
Carraway, Weber, Unger et al.: "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases." in: Nature, Vol. 387, Issue 6632, pp. 512-6, 1997 (PubMed).
ImagesProduct Details anti-Neuregulin 2 Antibody Target Details Neuregulin 2 Application Details Handling References for anti-Neuregulin 2 Antibody (ABIN1882105) back to top