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Browse our NFAT1 Proteins (NFAT1)

Full name:
Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 Proteins (NFAT1)
On www.antibodies-online.com are 7 Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) Proteins from 4 different suppliers available. Additionally we are shipping NFAT1 Antibodies (152) and NFAT1 Kits (6) and many more products for this protein. A total of 171 NFAT1 products are currently listed.
Synonyms:
AI607462, NF-ATc2, NFAT1, NFAT1-D, NFATC2, NFATP
list all proteins Gene Name GeneID UniProt
NFAT1 18019 Q60591
NFAT1 4773 Q13469
Rat NFAT1 NFAT1 311658  

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NFAT1 Proteins (NFAT1) by Origin

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Mouse (Murine) Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) interaction partners

  1. These results demonstrate a repressor role for NFAT1 in cell cycle progression and Cyclin E (show CCNE1 Proteins) expression in B lymphocytes, and suggest a potential function for NFAT1 protein in B cell malignancies.

  2. Overexpression of either ca-Nfatc2 or ca-Nfatc1 (show NFATC1 Proteins) in mouse islets enhanced insulin (show INS Proteins) secretion, whereas only ca-Nfatc2 was able to promote b-cell proliferation, suggesting distinct molecular pathways mediating insulin (show INS Proteins) secretion vs. b-cell proliferation are regulated by NFAT (show NFATC1 Proteins)

  3. our results suggest the NFAT1 plays a pivotal role as a genetic switch in CD4 (show CD4 Proteins)(+)/CD8 (show CD8A Proteins)(+) T cell tolerance by regulating AICD process in the T cell mediated skin inflammation.

  4. It is a non-Hsp gene, which is essential for HSF1 (show HSF1 Proteins)-mediated maintenance of whole body homeostasis

  5. NFAT (show NFATC1 Proteins) directs signaling enzymes to gene promoters in islets.

  6. FOXP3 (show FOXP3 Proteins) can inhibit NFAT (show NFATC1 Proteins) driven expression of CD40L (show CD40LG Proteins) and IL-17 (show IL17A Proteins) in CD4 (show CD4 Proteins) T cells through its interaction with NFAT1 and inhibition of this interaction by a short synthetic peptide can modulate effector T cell activity

  7. Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.

  8. our findings reveal a new signaling pathway in microglia that couples TLR4 (show TLR4 Proteins) activation with the translocation of NFAT1 into mitochondria to control the microglial activation during brain infection.

  9. In Nfat1(-/-) CD4 (show CD4 Proteins)(+) T cells, the expression of anti-inflammatory lymphokines was mediated by NFAT2 (show NFATC1 Proteins), thus directly enabling protective IL expression.

  10. Nfatc2 activation in osteoblasts inhibits bone formation and causes cancellous bone osteopenia.

Human Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) interaction partners

  1. These results demonstrate a repressor role for NFAT1 in cell cycle progression and Cyclin E (show CCNE1 Proteins) expression in B lymphocytes, and suggest a potential function for NFAT1 protein in B cell malignancies.

  2. revealed more than 170 NFAT (show NFATC1 Proteins)-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 (show NFATC1 Proteins) and NFATc2 in T cells, such as Raptor (show RPTOR Proteins), CHEK1 (show CHEK1 Proteins), CREB1 (show CREB1 Proteins), RUNX1 (show RUNX1 Proteins), SATB1 (show SATB1 Proteins), Ikaros (show IKZF1 Proteins), and Helios (show ZNFN1A2 Proteins).

  3. NFAT1 silencing could suppress cell migration and invasion through MMP-3 (show MMP3 Proteins).

  4. FOXP1 (show FOXP1 Proteins) has protein-protein interaction with NFAT1 on DNA and enhances breast cancer cell migration by repressing NFAT1 transcriptional activity.

  5. we describe a novel mechanism by which GSK-3beta fine-tunes NFATc2 and STAT3 (show STAT3 Proteins) transcriptional networks to integrate upstream signaling events that govern pancreatic cancer progression and growth.

  6. Up-regulation of Store-operated Ca2 (show CA2 Proteins)+ Entry and Nuclear Factor of Activated T Cells Promote the Acinar Phenotype of the Primary Human Salivary Gland Cells.

  7. two NFAT isoforms (NFAT4 and NFAT1) have shifted band-pass windows for the same receptor in the GPCR signaling pathway

  8. Data indicate that RNA interference of NFAT (show NFATC1 Proteins) isoforms NFATc1 (show NFATC1 Proteins), NFATc2, NFATc3 (show NFATC3 Proteins) and NFATc4 (show NFATC4 Proteins) regulate gene expression differentially in human retinal microvascular endothelial cells (HRMEC).

  9. These data suggest that NFATc2 expression is regulated by intracellular calcium and in vitro stretch, and that the stretch response in human myometrial cells is dependent upon intracellular calcium signalling pathways.

  10. inhibits CCR7 (show CCR7 Proteins) expression during the course of dendritic cell maturation

NFAT1 Protein Profile

Protein Summary

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized.

Alternative names and synonyms associated with NFAT1

  • nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (NFATC2)
  • nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (nfatc2)
  • nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 (Nfatc2)
  • nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Nfatc2)
  • AI607462 protein
  • NF-ATc2 protein
  • NFAT1 protein
  • NFAT1-D protein
  • NFATC2 protein
  • NFATP protein

Protein level used designations for NFAT1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 , nuclear factor of activated T-cells, cytoplasmic 2-like , NF-ATp , NFAT pre-existing subunit , T-cell transcription factor NFAT1 , nuclear factor of activated T-cells, cytoplasmic 2 , NF-ATc2 , NFAT transcription complex, preexisting component , T cell transcription factor NFAT1 , nuclear factor of activated T-cells, preexisting component , preexisting nuclear factor of activated T-cells 2

GENE ID SPECIES
100052657 Equus caballus
469972 Pan troglodytes
100450332 Pongo abelii
100464798 Ailuropoda melanoleuca
100542144 Meleagris gallopavo
100556205 Anolis carolinensis
100599959 Nomascus leucogenys
710601 Macaca mulatta
100414856 Callithrix jacchus
100490186 Xenopus (Silurana) tropicalis
18019 Mus musculus
4773 Homo sapiens
311658 Rattus norvegicus
485930 Canis lupus familiaris
100134969 Sus scrofa
530401 Bos taurus
419346 Gallus gallus
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