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Transplantation from GRIM19 (show NDUFA13 ELISA Kits)-overexpressing cells downregulated the expression of nuclear factor of activated T cells (NFATc1) but promoted the expression of regulator of calcineurin (RCAN)3 (show RCAN3 ELISA Kits) while downregulating NFAT-dependent cytokine gene expression.
These results suggest that the Keap1 (show KEAP1 ELISA Kits)/Nrf2 (show NFE2L2 ELISA Kits) axis plays a critical role in NFATc1 expression and osteoclastogenic progression.
Inhibition of calcineurin activity with FK506 or blockage of L-type calcium channels with nifedipine significantly suppressed NFATc1 mRNA expression and CTSK (show CTSK ELISA Kits) protein expression.
astrocytes were strongly associated with proteolysis of the protein phosphatase calcineurin (CN) and the elevated expression of the CN-dependent transcription factor nuclear factor of activated T cells 4 (NFAT4 (show NFATC3 ELISA Kits)
In studies of human and mouse pancreatic cells and tissue, we identified context-specific epigenetic regulation of NFATc1 activity as an important mechanism of pancreatic cell plasticity.
Immunoreceptor tyrosine-based inhibitory motif DC-STAMP (show TM7SF4 ELISA Kits) is a functional motif that regulates osteoclast differentiation through the NFATc1/Ca(2 (show CA2 ELISA Kits)+) axis.
TNF (show TNF ELISA Kits)/IL-6 (show IL6 ELISA Kits) generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1, DNAX-activation protein 12 (show TYROBP ELISA Kits), and cell proliferation.
PRIP (show NCOA6 ELISA Kits) deficiency impairs osteoclast differentiation, particularly at the early stages, and PRIP (show NCOA6 ELISA Kits) stimulates osteoclast differentiation through calcium-calcineurin-NFATc1 signaling via regulating intracellular Ca(2 (show CA2 ELISA Kits)+)
Results suggest that 25-hydroxycholesterol (25-HC) induced the interaction between NFATc1 and Sp1 (show SP1 ELISA Kits), reducing the level of free Sp1 (show SP1 ELISA Kits) to inhibit microRNA miR (show MLXIP ELISA Kits)-139-5p expression and promote osteoclastogenesis.
In summary, gastrodin could prevent osteoclasts formation and bone resorption via blockage of NFATc1 activity, and stimulate osseointegration in vitro. Gastrodin could be developed as a potent phytochemical candidate to treat osteolytic diseases.
Pathway analysis of the genes associated with the 46 CpG sites revealed an enrichment of immune system process genes, including LYST (show LYST ELISA Kits) (cg16962115, FDR = 1.24E-04), CADM1 (show CADM1 ELISA Kits) (cg21933078, FDR = 1.22E-02) and NFATC1 (cg06784563, FDR = 1.46E-02)
there is an NFATc1/ABCA1 (show ABCA1 ELISA Kits)-dependent mechanism in which local TNF (show TNF ELISA Kits) is sufficient to cause free cholesterol-dependent podocyte injury irrespective of TNF (show TNF ELISA Kits), TNFR1 (show TNFRSF1A ELISA Kits), or TNFR2 (show TNFRSF1B ELISA Kits) serum levels
NFATC1 transcription factor (NFATc1) expression is detected in prostate cancer (PCa (show FLVCR1 ELISA Kits)) specimens and PCa (show FLVCR1 ELISA Kits) cells but is absent in non-neoplastic human prostates and non-tumorigenic prostatic cells
DYRK1A phosphorylation of NFATc1/alphaA at S261, S278, S403 and S409 interfered with NFATc1 ubiquitination and ubiquitin-proteasome degradation.
NFATC1 rs3894049 GC was a risk factor for acute rejection in renal transplant recipients compared with CC carriers.
revealed more than 170 NFAT-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 and NFATc2 (show NFAT1 ELISA Kits) in T cells, such as Raptor (show RPTOR ELISA Kits), CHEK1 (show CHEK1 ELISA Kits), CREB1 (show CREB1 ELISA Kits), RUNX1 (show RUNX1 ELISA Kits), SATB1 (show SATB1 ELISA Kits), Ikaros (show IKZF1 ELISA Kits), and Helios (show ZNFN1A2 ELISA Kits).
NFATc1 silencing regulates the cell cycle.
Study showed that luteolin and apigenin effectively maintain pluripotency of PDLCs through activation of Oct-4 (show POU5F1 ELISA Kits)/Sox2 (show SOX2 ELISA Kits) signal via NFATc1.
The enhanced osteoclast formation by TECK (show CCL25 ELISA Kits) was mediated by NFATc1, but not by NF-kB signaling.
In calf pulmonary artery endothelial cells, extracellular application of vasoactive agonist ATP or calcium ionophore ionomycin generates a rise in intracellular calcium that induces nuclear localization of NFATc1.
regulation of nuclear localization of NFAT is isoform-specific and dependent on nuclear export processes
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
, nuclear factor of activated T-cells, cytosolic component 1
, nuclear factor of activated T-cells calcineurin-dependent 1
, nuclear factor of activated T-cells, cytoplasmic 1
, nuclear factor of activated T-cells, cytoplasmic 1-like
, NFAT transcription complex cytosolic component
, transcription factor NF-ATc
, transcription factor NFATmac