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Transplantation from GRIM19 (show NDUFA13 Proteins)-overexpressing cells downregulated the expression of nuclear factor of activated T cells (NFATc1) but promoted the expression of regulator of calcineurin (RCAN)3 (show RCAN3 Proteins) while downregulating NFAT-dependent cytokine gene expression.
These results suggest that the Keap1 (show KEAP1 Proteins)/Nrf2 (show NFE2L2 Proteins) axis plays a critical role in NFATc1 expression and osteoclastogenic progression.
Inhibition of calcineurin activity with FK506 or blockage of L-type calcium channels with nifedipine significantly suppressed NFATc1 mRNA expression and CTSK (show CTSK Proteins) protein expression.
astrocytes were strongly associated with proteolysis of the protein phosphatase calcineurin (CN) and the elevated expression of the CN-dependent transcription factor nuclear factor of activated T cells 4 (NFAT4 (show NFATC3 Proteins)
In studies of human and mouse pancreatic cells and tissue, we identified context-specific epigenetic regulation of NFATc1 activity as an important mechanism of pancreatic cell plasticity.
Immunoreceptor tyrosine-based inhibitory motif DC-STAMP is a functional motif that regulates osteoclast differentiation through the NFATc1/Ca(2 (show CA2 Proteins)+) axis.
TNF (show TNF Proteins)/IL-6 (show IL6 Proteins) generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1, DNAX-activation protein 12 (show TYROBP Proteins), and cell proliferation.
PRIP (show NCOA6 Proteins) deficiency impairs osteoclast differentiation, particularly at the early stages, and PRIP (show NCOA6 Proteins) stimulates osteoclast differentiation through calcium-calcineurin-NFATc1 signaling via regulating intracellular Ca(2 (show CA2 Proteins)+)
Results suggest that 25-hydroxycholesterol (25-HC) induced the interaction between NFATc1 and Sp1 (show SP1 Proteins), reducing the level of free Sp1 (show SP1 Proteins) to inhibit microRNA miR (show MLXIP Proteins)-139-5p expression and promote osteoclastogenesis.
In summary, gastrodin could prevent osteoclasts formation and bone resorption via blockage of NFATc1 activity, and stimulate osseointegration in vitro. Gastrodin could be developed as a potent phytochemical candidate to treat osteolytic diseases.
Pathway analysis of the genes associated with the 46 CpG sites revealed an enrichment of immune system process genes, including LYST (cg16962115, FDR = 1.24E-04), CADM1 (show CADM1 Proteins) (cg21933078, FDR = 1.22E-02) and NFATC1 (cg06784563, FDR = 1.46E-02)
there is an NFATc1/ABCA1 (show ABCA1 Proteins)-dependent mechanism in which local TNF (show TNF Proteins) is sufficient to cause free cholesterol-dependent podocyte injury irrespective of TNF (show TNF Proteins), TNFR1 (show TNFRSF1A Proteins), or TNFR2 (show TNFRSF1B Proteins) serum levels
NFATC1 transcription factor (NFATc1) expression is detected in prostate cancer (PCa (show FLVCR1 Proteins)) specimens and PCa (show FLVCR1 Proteins) cells but is absent in non-neoplastic human prostates and non-tumorigenic prostatic cells
DYRK1A phosphorylation of NFATc1/alphaA at S261, S278, S403 and S409 interfered with NFATc1 ubiquitination and ubiquitin-proteasome degradation.
NFATC1 rs3894049 GC was a risk factor for acute rejection in renal transplant recipients compared with CC carriers.
revealed more than 170 NFAT-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 and NFATc2 (show NFAT1 Proteins) in T cells, such as Raptor (show RPTOR Proteins), CHEK1 (show CHEK1 Proteins), CREB1 (show CREB1 Proteins), RUNX1 (show RUNX1 Proteins), SATB1 (show SATB1 Proteins), Ikaros (show IKZF1 Proteins), and Helios (show ZNFN1A2 Proteins).
NFATc1 silencing regulates the cell cycle.
Study showed that luteolin and apigenin effectively maintain pluripotency of PDLCs through activation of Oct-4 (show POU5F1 Proteins)/Sox2 (show SOX2 Proteins) signal via NFATc1.
The enhanced osteoclast formation by TECK (show CCL25 Proteins) was mediated by NFATc1, but not by NF-kB signaling.
In calf pulmonary artery endothelial cells, extracellular application of vasoactive agonist ATP or calcium ionophore ionomycin generates a rise in intracellular calcium that induces nuclear localization of NFATc1.
regulation of nuclear localization of NFAT is isoform-specific and dependent on nuclear export processes
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
, nuclear factor of activated T-cells, cytosolic component 1
, nuclear factor of activated T-cells calcineurin-dependent 1
, nuclear factor of activated T-cells, cytoplasmic 1
, nuclear factor of activated T-cells, cytoplasmic 1-like
, NFAT transcription complex cytosolic component
, transcription factor NF-ATc
, transcription factor NFATmac