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Browse our NFATC1 Proteins (NFATC1)

Full name:
Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 Proteins (NFATC1)
On www.antibodies-online.com are 5 Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1) Proteins from 4 different suppliers available. Additionally we are shipping NFATC1 Antibodies (152) and NFATC1 Kits (17) and many more products for this protein. A total of 184 NFATC1 products are currently listed.
Synonyms:
2210017P03Rik, AI449492, AV076380, NF-ATC, NF-ATc1, NFAT, NFAT2, NFATc, NFATC1, Nfatcb, NFATmac, si:ch211-198c22.2
list all proteins Gene Name GeneID UniProt
NFATC1 18018  
NFATC1 4772 O95644
Rat NFATC1 NFATC1 100361818  

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NFATC1 Proteins (NFATC1) by Origin

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More Proteins for NFATC1 Interaction Partners

Mouse (Murine) Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1) interaction partners

  1. Results suggest that 25-hydroxycholesterol (25-HC) induced the interaction between NFATc1 and Sp1 (show SP1 Proteins), reducing the level of free Sp1 (show SP1 Proteins) to inhibit microRNA miR (show MLXIP Proteins)-139-5p expression and promote osteoclastogenesis.

  2. In summary, gastrodin could prevent osteoclasts formation and bone resorption via blockage of NFATc1 activity, and stimulate osseointegration in vitro. Gastrodin could be developed as a potent phytochemical candidate to treat osteolytic diseases.

  3. this study shows that lipopolysaccharide priming of dendritic cells stabilizes their tolerogenicity through CD14 (show CD14 Proteins):NFATc signaling

  4. NFATc1

  5. MK serves an indispensable role in the NFAT-regulated activation of CD4 (show CD4 Proteins)(+) T cells and Th1 (show HAND1 Proteins) cell differentiation.

  6. Overexpression of either ca-Nfatc2 (show NFAT1 Proteins) or ca-Nfatc1 in mouse islets enhanced insulin (show INS Proteins) secretion, whereas only ca-Nfatc2 (show NFAT1 Proteins) was able to promote b-cell proliferation, suggesting distinct molecular pathways mediating insulin (show INS Proteins) secretion vs. b-cell proliferation are regulated by NFAT

  7. Cadm1 (show CADM1 Proteins) is a direct target of NFATc1, which is induced by RANKL (show TNFSF11 Proteins) through epigenetic modification, and regulates osteoclastic bone resorption in a negative feedback manner.

  8. Cyclosporin A can prevent benzo[alpha]pyrene induced lung tissue damage, and it remarkably decreases NFATc1 expression in mouse lung tissue. NFATc1 expression was reduced in CsA-treated animals.

  9. the protein and RNA levels of RANKLinduced cFos and nuclear factor of activated T-cell (show NFATC3 Proteins) cytoplasmic 1 were suppressed by centipedegrass extract (CGE). These results indicated that CGE may serve as a useful drug in the prevention of bone loss.

  10. The enhanced osteoclast formation by TECK (show CCL25 Proteins) was mediated by NFATc1, but not by NF-kB signaling.

Human Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1) interaction partners

  1. revealed more than 170 NFAT-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 and NFATc2 (show NFAT1 Proteins) in T cells, such as Raptor (show RPTOR Proteins), CHEK1 (show CHEK1 Proteins), CREB1 (show CREB1 Proteins), RUNX1 (show RUNX1 Proteins), SATB1 (show SATB1 Proteins), Ikaros (show IKZF1 Proteins), and Helios (show ZNFN1A2 Proteins).

  2. NFATc1 silencing regulates the cell cycle.

  3. Study showed that luteolin and apigenin effectively maintain pluripotency of PDLCs through activation of Oct-4 (show POU5F1 Proteins)/Sox2 (show SOX2 Proteins) signal via NFATc1.

  4. The enhanced osteoclast formation by TECK (show CCL25 Proteins) was mediated by NFATc1, but not by NF-kB signaling.

  5. NFATC1 promoteds growth of ovarian cancer cells up-regulating c-myc (show MYC Proteins) through activation of ERK1/2/p38/MAPK (show MAPK14 Proteins) signal pathway.

  6. The results demonstrate the importance of NFAT activation during PMA-induced mesenchymal stem cells differentiation.

  7. it was shown that NFATc1 siRNA significantly suppresses the growth and vascular generation of SKOV3 human ovarian carcinoma cell-transplanted tumors subcutaneously xenografted into nude mice.

  8. Data indicate that RNA interference of NFAT isoforms NFATc1, NFATc2 (show NFAT1 Proteins), NFATc3 (show NFATC3 Proteins) and NFATc4 (show NFATC4 Proteins) regulate gene expression differentially in human retinal microvascular endothelial cells (HRMEC).

  9. NFATc1binds the GLI1 (show GLI1 Proteins) promoter and represses its transcription.

  10. InB may exhibit growth-inhibitory activity through the activation of PKCalpha (show PKCa Proteins), followed by an increase in NFAT transactivation ability.

Cow (Bovine) Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1) interaction partners

  1. In calf pulmonary artery endothelial cells, extracellular application of vasoactive agonist ATP or calcium ionophore ionomycin generates a rise in intracellular calcium that induces nuclear localization of NFATc1.

  2. regulation of nuclear localization of NFAT is isoform-specific and dependent on nuclear export processes

NFATC1 Protein Profile

Protein Summary

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

Alternative names and synonyms associated with NFATC1

  • nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATC1)
  • nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (nfatc1)
  • nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 (Nfatc1)
  • nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (Nfatc1)
  • 2210017P03Rik protein
  • AI449492 protein
  • AV076380 protein
  • NF-ATC protein
  • NF-ATc1 protein
  • NFAT protein
  • NFAT2 protein
  • NFATc protein
  • NFATC1 protein
  • Nfatcb protein
  • NFATmac protein
  • si:ch211-198c22.2 protein

Protein level used designations for NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 , nuclear factor of activated T-cells, cytosolic component 1 , nuclear factor of activated T-cells calcineurin-dependent 1 , nuclear factor of activated T-cells, cytoplasmic 1 , nuclear factor of activated T-cells, cytoplasmic 1-like , NF-ATc1 , NFAT transcription complex cytosolic component , transcription factor NF-ATc , NFATc , transcription factor NFATmac

GENE ID SPECIES
420815 Gallus gallus
444346 Xenopus laevis
455485 Pan troglodytes
568315 Danio rerio
698089 Macaca mulatta
780197 Xenopus (Silurana) tropicalis
100023153 Monodelphis domestica
100065378 Equus caballus
100436209 Pongo abelii
100470861 Ailuropoda melanoleuca
100545778 Meleagris gallopavo
100565300 Anolis carolinensis
18018 Mus musculus
4772 Homo sapiens
100361818 Rattus norvegicus
483925 Canis lupus familiaris
511224 Bos taurus
397318 Sus scrofa
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