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|Antigen||Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 3 (NFATC3) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-NFATC3 AntibodyTarget Details NFATC3 Application Details Handling Images
|Specificity||This antibody detects endogenous levels of NFAT4 protein. (region surrounding Glu159)|
|Cross-Reactivity (Details)||Species reactivity (tested):Human and Mouse.|
|Purification||Affinity Chromatography using epitope-specific immunogen.|
Target Details NFATC3Product Details anti-NFATC3 Antibody Application Details Handling Images back to top
|Alternative Name||NFAT4 / NFATC3 (NFATC3 Antibody Abstract)|
|Background||NFATc4 (nuclear factor of activated T cells, cytoplasmic, calcineurindependent 4) is a member of the nuclear factors of activated T cells DNAbinding transcription complex that influences cytokine gene expression, cardiac hypertrophy and adipocyte differentiation. This complex consists of at least two components, a cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate in the formation of this complex. NFATc4 plays a role in the inducible expression of cytokine genes in T cells, including the induction of IL-2 and IL-4. p38 MAP kinase phosphorylates multiple residues in the NFAT homology domain of NFATc4.Synonyms: NF-ATc3, NFATc3, Nuclear factor of activated T-cells, T-cell transcription factor NFAT4, T-cell transcription factor NFAT4, cytoplasmic 3|
|Molecular Weight||approx. 115 kDa|
|Pathways||RTK Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, Chromatin Binding|
Application DetailsProduct Details anti-NFATC3 Antibody Target Details NFATC3 Handling Images back to top
ELISA: 1/10000approx. 1/20000. Western Blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-NFATC3 Antibody Target Details NFATC3 Application Details Images back to top
|Buffer||Phosphate buffered saline (PBS), pH 7.2., 0.05 % Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
ImagesProduct Details anti-NFATC3 Antibody Target Details NFATC3 Application Details Handling back to top