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regulation of nuclear localization of NFAT (show NFATC1 ELISA Kits) is isoform-specific and dependent on nuclear export processes
Both NFATc3 knock-out mice and ILK (show ILK ELISA Kits) conditional-knockdown mice (cKD-ILK (show ILK ELISA Kits)) display symptoms of NDI (show AVPR2 ELISA Kits) (polyuria and reduced AQP2 (show AQP2 ELISA Kits) expression).
we found that VIP (show Vip ELISA Kits) inhibits NFAT (show NFATC1 ELISA Kits) nuclear translocation in primary human pulmonary artery smooth muscle cells (PASMC). Early activation of NFATc3 in IPF patients may contribute to disease progression and the increase in VIP (show Vip ELISA Kits) expression could be a protective compensatory mechanism
the transcription factor NFATC3 binds to IRF7 (show IRF7 ELISA Kits) and functions synergistically to enhance IRF7 (show IRF7 ELISA Kits)-mediated IFN expression in Plasmacytoid dendritic cells.
Ca(2 (show CA2 ELISA Kits)+) influx through ASIC1 (show ACCN2 ELISA Kits) mediates chronic hypoxia and ET-1 (show EDN1 ELISA Kits)-induced NFATc3 nuclear import and 2) the scaffolding protein PICK1 (show PICK1 ELISA Kits) is necessary for NFATc3 nuclear import.
AKAP150-calcineurin signaling dyad is essential for the activation of the phosphatase and the subsequent down-regulation of Kv channel currents following myocardial infarction.
Study defines the NFAT4/ miR (show MLXIP ELISA Kits)-324-5p/Mtfr1 (show MTFR1 ELISA Kits) axis, which participates in the regulation of mitochondrial fission and cardiomyocyte apoptosis.
Disrupting the calcineurin-NFAT (show NFATC1 ELISA Kits) axis by either genetic or pharmacologic approaches confers resistance to the development of social stress-induced voiding and dysfunction.
NFATc3 interacted in a SUMO-dependent manner with Trim17, an E3 ubiquitin ligase necessary for neuronal apoptosis
A calcineurin- and NFAT-dependent pathway is involved in alpha-synuclein-induced degeneration of midbrain dopaminergic neurons in a Parkinson's disease mouse model.
study demonstrates for the first time that NFATc3 is necessary for macrophage iNOS (show NOS2 ELISA Kits) expression during sepsis, which is essential for containment of bacterial infections.
The NFATc3 first induced the expression of its interaction partner FosB (show FOSB ELISA Kits) before forming the heterodimeric NFATc3-FosB (show FOSB ELISA Kits) transcription factor complex, which bound the proximal AP-1 (show FOSB ELISA Kits) site in the TF gene promoter and activated TF expression.
NFAT1 (show NFAT1 ELISA Kits) is stimulated by subplasmalemmal Ca2 (show CA2 ELISA Kits)+ microdomains, whereas NFAT4 additionally requires Ca2 (show CA2 ELISA Kits)+ mobilization from the inner nuclear envelope by nuclear InsP3 receptors.
Calcineurin together with its upstream molecule, calpain 2 (show CAPN2 ELISA Kits), and its downstream effector, NFAT (show NFATC1 ELISA Kits)-c3, might contribute to the development of atrial fibrillation in patients with heart valve disease and diabetes.
two NFAT isoforms (NFAT4 and NFAT1) have shifted band-pass windows for the same receptor in the GPCR signaling pathway
Data indicate that RNA interference of NFAT (show NFATC1 ELISA Kits) isoforms NFATc1 (show NFATC1 ELISA Kits), NFATc2 (show NFAT1 ELISA Kits), NFATc3 and NFATc4 (show NFATC4 ELISA Kits) regulate gene expression differentially in human retinal microvascular endothelial cells (HRMEC).
Results show that two protein isoforms NFAT1 (show NFAT1 ELISA Kits) and NFAT4 are both cytosolic and stimulated by the same Ca2 (show CA2 ELISA Kits)+ messenger but require distinct subcellular Ca2 (show CA2 ELISA Kits)+ signals for activity.
Suggest nuclear NF-AT3 (show NFATC4 ELISA Kits) and NF-AT4 participates in atrial structural remodeling, and that PICP and TGF-beta1 (show TGFB1 ELISA Kits) levels may be sensitive serum biomarkers to estimate atrial structural remodeling with atrial fibrillation.
NF-AT affects neural convergent extension.
transcriptional control of morphological and electrophysiological properties of neurons is mediated by distinct NFAT (show NFATC1 ELISA Kits) interactions
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene.
cytoplasmic nuclear factor of activated T-cells 3
, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
, nuclear factor of activated T-cells, cytoplasmic 3
, nuclear factor of activated T-cells, cytoplasmic 3-like
, T-cell transcription factor NFAT4
, T cell transcription factor NFAT4
, nuclear factor of activated T-cells c3 isoform IE-Xa
, nuclear factor of activated T-cell