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We report the case of a patient with an initial diagnosis of salivary acinic cell carcinoma later reclassified as Mammary analogue secretory carcinoma after next-generation sequencing revealed an ETV6-NTRK3 fusion.
Data suggest that kinase domains of neurotrophin (show BDNF Proteins) receptor isoforms, TRKA (show NTRK1 Proteins), TRKB (show NTRK2 Proteins), and TRKC, exhibit a bulky phenylalanine gatekeeper, leading to a small and unattractive back pocket/binding site for antineoplastic kinase inhibitors. [REVIEW]
Pan-Trk (show NTRK1 Proteins) immunohistochemistry is a time-efficient and tissue-efficient screen for NTRK fusions, particularly in driver-negative advanced malignancies and potential cases of secretory carcinoma and congenital fibrosarcoma.
5 gastrointestinal stromal tumors cases lacking alterations in the KIT/PDGFRA (show PDGFRA Proteins)/SDHx/RAS pathways, including two additional cases with FGFR1 (show FGFR1 Proteins)-TACC1 (show TACC1 Proteins) and ETV6 (show ETV6 Proteins)-NTRK3 fusions, are reported.
High expression of TrkC is associated with glioblastoma.
Study found that copy number variations of NTRK3 were associated with platinum-sensitive and platinum-resistant recurrences. Amplification of NTRK3 perfectly predicted platinum-sensitive relapse of ovarian cancer.
we demonstrate the expression of the ETV6-NTRK3 fusion oncogene (show RAB1A Proteins) in a small subset of inflammatory myofibroblastic tumors
ETV6 (show ETV6 Proteins)-NTRK3 translocated papillary thyroid carcinomas are locoregionally aggressive and can metastasize distantly.
We report 6 cases of secretory carcinomas of the skin harboring the ETV6 (show ETV6 Proteins)-NTRK3 gene fusion
ETV6-NTRK3, MYO5A-NTRK3 and MYH9-NTRK3 fusions are identified in Spitz tumours and demonstrated that NTRK3 fusions constitutively activate the mitogen-activated protein kinase, phosphoinositide 3-kinase and phospholipase Cgamma1 pathways in melanocytes.
our data suggest that Runx3 (show RUNX3 Proteins) may play a crucial role in the development of DRGs by regulating the expression of Ntrk3 variants
adult homozygous TrkAC knock-in mice displayed severe deficits in acute and tissue injury-induced pain, representing the first viable adult Trk (show NTRK1 Proteins) mouse mutant with a pain phenotype
TrkC expression in E13.5 VCG neurons requires NeuroD (show NEUROD1 Proteins) and that TrkC expression may be necessary for the normal migration and innervations of those neurons.
The dependence receptor TrkC interacts with Cobra1 (show COBRA1 Proteins).TrkC killer fragment shuttles with Cobra1 (show COBRA1 Proteins) to the mitochondria to engage apoptosis.
ETV6 (show ETV6 Proteins)-SAM (show TTN Proteins) domain interface mutations block ETV6 (show ETV6 Proteins)-NTRK3-induced cellular transformation
This study demonistrated that NTRK3 plays a role in panic disorder by regulating hippocampus-dependent fear memories.
Despite elimination of TrkC mRNA, no differences in development of kindling were detected between TrkC conditional null and wild type control mice.
find that both IRS1 (show IRS1 Proteins) and kinase active IGF1R (show IGF1R Proteins) are required for ETV6 (show ETV6 Proteins)-NTRK3 transformation, that tyrosine phosphorylated IRS1 (show IRS1 Proteins) is present in high molecular weight complexes with EN and IGF1R (show IGF1R Proteins), and that EN colocalizes with IGF1R (show IGF1R Proteins) at the plasma membrane
Data describe the distribution and changes of TrkB (show NTRK2 Proteins) and TrkC in the dopamine neurons of the substantia nigra by comparison of control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP (show PTPN2 Proteins)) Parkinson disease mouse model.
Data suggest that postsynaptic TrkC trans interaction with presynaptic PTPsigma (show PTPRS Proteins) generates bidirectional adhesion and recruitment essential for excitatory synapse development and positions these signaling molecules at the center of synaptic pathways.
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.
ETS related protein-neurotrophic receptor tyrosine kinase fusion protein
, ETV6-NTRK3 fusion
, NT-3 growth factor receptor
, tyrosine kinase receptor C
, neural receptor protein-tyrosine kinase (trkC)
, trkC tyrosine kinase
, neurotrophic tyrosine kinase receptor type 3
, tyrosine kinase C receptor, TrkC receptor, high-affinity neurotrophin receptor
, neurotrophic tyrosine kinase, receptor, type 3
, NT-3 growth factor receptor-like