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Human PAK4 Protein expressed in Escherichia coli (E. coli) - ABIN666714
Li, Minden: PAK4 functions in tumor necrosis factor (TNF) alpha-induced survival pathways by facilitating TRADD binding to the TNF receptor. in The Journal of biological chemistry 2005
Show all 2 references for ABIN666714
High expression of PAK4 is associated with breast cancer.
In gastric cancer, High PAK4 expression was significantly correlated with clinicopathological variables related to tumour progression, including depth of invasion, metastatic lymph nodes, pathological stage, distant metastasis or recurrent disease. High PAK4 expression was significantly associated with poorer disease-specific survival and relapse-free survival.
PAK4 methylation by SETD6 (show SETD6 Proteins) promotes the activation of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.
Study has confirms prognostic role of PAK4 level in cervical cancer patients and recognizes the regulatory role in cervical cancer progression. PAK4 also confers the chemoresistance of cervical cancer cells in a PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)-dependent way.
PAK4 catalytic domain binds cellular ATP and the Inka1 inhibitor. The crystal lattice consists only of PAK4-PAK4 contacts, which form a hexagonal array with channels of 80 A in diameter that run the length of the crystal.
PAK4 localizes to cell-cell junctions and contributes to estblishing cell polarity.PAK4 phosphorylate beta-catenin (show CTNNB1 Proteins) Serine-675.PAK4 binding to cell-cell junctions is dependent on Cdc42 (show CDC42 Proteins).
Nuclear Pak4 is involved in the pathogenesis of endometrial cancer especially in postmenopausal women.
data show decreased nuclear accumulation and transcriptional activity of STAT3 (show STAT3 Proteins) in PAK4-silenced pancreatic cancer cells
this report reveals that high level of p-Pak4 correlates with poor prognosis in gastric cancer (GC), thereby suggesting that p-Pak4 might be a potential prognostic marker for GC.
PAK4 and RhoU (show RHOU Proteins) cooperate to drive adhesion turnover and promote cell migration.
These data demonstrate the relevance of PAK4 in osteoclast differentiation and the potential of PAK4 inhibitors for treating osteoclast-related disorders.
PAK4 promotes alpha-MSH/UVB-induced melanogenesis via the CREB (show CREB1 Proteins) and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathways and suggest that PAK4 may be a potential therapeutic target in pigmentation disorders.
PAK4 phosphorylates Par6B (show PARD6B Proteins) at Ser143 blocking its interaction with Cdc42 (show CDC42 Proteins).
Defined here is the overlap in phosphopeptides regulated by K-Ras (show HRAS Proteins), Cdc42 (show CDC42 Proteins), and PAK4; perturbation of these signaling components affects phosphoproteins associated with microtubule depolymerization, cytoskeletal organization, and the cell cycle.
These results indicate that PAK4 functions, including control of actin dynamics, are necessary for normal development of the heart
p21-activated kinase 4 regulates regulatory myosin light chain phosphorylation and myosin contractility during FcgammaR-mediated phagocytosis.
the transient increase in PAK4 levels at early G1 reduces p21 levels, thereby abrogating the activity of CDK4 (show CDK4 Proteins)/CDK6 (show CDK6 Proteins) kinases, and allowing cells to proceed with the cell cycle in a precisely coordinated way
Conditional Pak4 knockout mice were born normally, but displayed growth retardation and died prematurely. The brains showed a dramatic decrease in proliferation of cortical and striatal neuronal progenitor cells.
results suggest that overexpression of Pak4 triggers events that are important for the transformation of mammary epithelial cells
PAK4 interacts with KGF (show FGF7 Proteins) receptor and mediate anti-apoptosis effects of KGF (show FGF7 Proteins) on epithelial cells.
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
p21-activated kinase 4
, p21(CDKN1A)-activated kinase 4
, protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs
, serine/threonine-protein kinase PAK 4
, p21 (CDKN1A)-activated kinase 4