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Browse our PAK4 Proteins (PAK4)

Full name:
P21-Activated Kinase 4 Proteins (PAK4)
On www.antibodies-online.com are 21 P21-Activated Kinase 4 (PAK4) Proteins from 11 different suppliers available. Additionally we are shipping PAK4 Antibodies (172) and PAK4 Kits (2) and many more products for this protein. A total of 206 PAK4 products are currently listed.
Synonyms:
5730488L07Rik, AW555722, mKIAA1142
list all proteins Gene Name GeneID UniProt
PAK4 10298 O96013
PAK4 70584 Q8BTW9
Rat PAK4 PAK4 292756  

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PAK4 Proteins (PAK4) by Origin

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Top referenced PAK4 Proteins

  1. Human PAK4 Protein expressed in Escherichia coli (E. coli) - ABIN666714 : Li, Minden: PAK4 functions in tumor necrosis factor (TNF) alpha-induced survival pathways by facilitating TRADD binding to the TNF receptor. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 references for ABIN666714

More Proteins for PAK4 Interaction Partners

Human P21-Activated Kinase 4 (PAK4) interaction partners

  1. PAK4 methylation by SETD6 (show SETD6 Proteins) promotes the activation of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.

  2. Study has confirms prognostic role of PAK4 level in cervical cancer patients and recognizes the regulatory role in cervical cancer progression. PAK4 also confers the chemoresistance of cervical cancer cells in a PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)-dependent way.

  3. PAK4 catalytic domain binds cellular ATP and the Inka1 inhibitor. The crystal lattice consists only of PAK4-PAK4 contacts, which form a hexagonal array with channels of 80 A in diameter that run the length of the crystal.

  4. PAK4 localizes to cell-cell junctions and contributes to estblishing cell polarity.PAK4 phosphorylate beta-catenin (show CTNNB1 Proteins) Serine-675.PAK4 binding to cell-cell junctions is dependent on Cdc42 (show CDC42 Proteins).

  5. Nuclear Pak4 is involved in the pathogenesis of endometrial cancer especially in postmenopausal women.

  6. data show decreased nuclear accumulation and transcriptional activity of STAT3 (show STAT3 Proteins) in PAK4-silenced pancreatic cancer cells

  7. this report reveals that high level of p-Pak4 correlates with poor prognosis in gastric cancer (GC), thereby suggesting that p-Pak4 might be a potential prognostic marker for GC.

  8. PAK4 and RhoU (show RHOU Proteins) cooperate to drive adhesion turnover and promote cell migration.

  9. PAK4 mediated LIMK1 (show LIMK1 Proteins) phosphorylation regulates the migration and invasion in NSCLC. Therefore, PAK4 might be a significant prognostic marker and potential therapeutic molecular target in NSCLC.

  10. CXCL12 (show CXCL12 Proteins)/CXCR4 (show CXCR4 Proteins) signaling has a role in docetaxel-induced microtubule stabilization via p21-activated kinase 4-dependent activation of LIMK1 (show LIMK1 Proteins)

Mouse (Murine) P21-Activated Kinase 4 (PAK4) interaction partners

  1. These data demonstrate the relevance of PAK4 in osteoclast differentiation and the potential of PAK4 inhibitors for treating osteoclast-related disorders.

  2. PAK4 promotes alpha-MSH/UVB-induced melanogenesis via the CREB (show CREB1 Proteins) and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathways and suggest that PAK4 may be a potential therapeutic target in pigmentation disorders.

  3. PAK4 phosphorylates Par6B (show PARD6B Proteins) at Ser143 blocking its interaction with Cdc42 (show CDC42 Proteins).

  4. Defined here is the overlap in phosphopeptides regulated by K-Ras (show HRAS Proteins), Cdc42 (show CDC42 Proteins), and PAK4; perturbation of these signaling components affects phosphoproteins associated with microtubule depolymerization, cytoskeletal organization, and the cell cycle.

  5. These results indicate that PAK4 functions, including control of actin dynamics, are necessary for normal development of the heart

  6. p21-activated kinase 4 regulates regulatory myosin light chain phosphorylation and myosin contractility during FcgammaR-mediated phagocytosis.

  7. the transient increase in PAK4 levels at early G1 reduces p21 levels, thereby abrogating the activity of CDK4 (show CDK4 Proteins)/CDK6 (show CDK6 Proteins) kinases, and allowing cells to proceed with the cell cycle in a precisely coordinated way

  8. Conditional Pak4 knockout mice were born normally, but displayed growth retardation and died prematurely. The brains showed a dramatic decrease in proliferation of cortical and striatal neuronal progenitor cells.

  9. results suggest that overexpression of Pak4 triggers events that are important for the transformation of mammary epithelial cells

  10. PAK4 interacts with KGF (show FGF7 Proteins) receptor and mediate anti-apoptosis effects of KGF (show FGF7 Proteins) on epithelial cells.

PAK4 Protein Profile

Protein Summary

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Alternative names and synonyms associated with PAK4

  • p21 protein (Cdc42/Rac)-activated kinase 4 (PAK4)
  • p21-activated kinase 4 (LOC100336246)
  • p21 protein (Cdc42/Rac)-activated kinase 4 (Pak4)
  • 5730488L07Rik protein
  • AW555722 protein
  • mKIAA1142 protein

Protein level used designations for P21-Activated Kinase 4 Proteins (PAK4)

p21-activated kinase 4 , PAK-4 , p21(CDKN1A)-activated kinase 4 , protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs , serine/threonine-protein kinase PAK 4 , p21 (CDKN1A)-activated kinase 4

GENE ID SPECIES
100067000 Equus caballus
100336246 Bos taurus
10298 Homo sapiens
70584 Mus musculus
292756 Rattus norvegicus
484513 Canis lupus familiaris
770462 Gallus gallus
539742 Bos taurus
100341934 Oryctolagus cuniculus
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