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|Antigen||Platelet-Derived Growth Factor beta Polypeptide (PDGFB) Antibodies|
|Epitope||AA 101-116 Alternatives|
|Reactivity||Human, Rat (Rattus) Alternatives|
|Conjugate||This PDGFB antibody is un-conjugated Alternatives|
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
|3 references available|
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Product Details anti-PDGFB AntibodyTarget Details PDGFB Application Details Handling References for anti-PDGFB antibody (ABIN115467) Images
|Specificity||This antibody is specific for PDGF beta form and reacts with PDGF (AB) and PDGF (BB) protein. Cellular localization: cytoplasmic.|
|Immunogen||A synthetic peptide derived from amino acids 101-116 of the Human PDGF beta chain.|
Target Details PDGFBProduct Details anti-PDGFB Antibody Application Details Handling References for anti-PDGFB antibody (ABIN115467) Images back to top
|Alternative Name||PDGFB (PDGFB Antibody Abstract)|
|Background||Platelet-Derived Growth Factor (PDGF) is the major serum mitogen for cells of mesenchymal origin in humans. The biologically active protein is a dimmer composed of two related polypeptides designated A and B. The PDGF protein has been implicated both directly as well as indirectly in several pathological states including neoplasia, arthritis, arteriosclerosis and bone marrow sclerosis.Synonyms: Becaplermin, PDGF B, PDGF beta, PDGF subunit B, PDGF-2, PDGF-B, PDGF2, Platelet-derived growth factor B chain, Platelet-derived growth factor beta, Platelet-derived growth factor subunit B, SIS, c-Sis|
|Research Area||Cytokines, Receptors, Inflammation|
|Pathways||RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling|
Application DetailsProduct Details anti-PDGFB Antibody Target Details PDGFB Handling References for anti-PDGFB antibody (ABIN115467) Images back to top
Immunohistochemistry: 1/50-1/100 in an ABC method for 30 minutes at room temperature. Formalin Fixed Paraffin Embedded Tissue Sections require high temperature antigenunmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Recommended Positive Control: Angiosarcoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-PDGFB Antibody Target Details PDGFB Application Details References for anti-PDGFB antibody (ABIN115467) Images back to top
|Storage Comment||Store the antibody undiluted at 2-8 °C.|
References for anti-PDGFB antibody (ABIN115467)Product Details anti-PDGFB Antibody Target Details PDGFB Application Details Handling Images back to top
|Product cited in:||
van Steensel, Paridaens, van Meurs, van Hagen, van den Bosch, Kuijpers, Drexhage, Hooijkaas, Dik: "Orbit-infiltrating mast cells, monocytes, and macrophages produce PDGF isoforms that orchestrate orbital fibroblast activation in Graves' ophthalmopathy." in: The Journal of clinical endocrinology and metabolism, Vol. 97, Issue 3, pp. E400-8, 2012
Hayes, Harrison, Bouchier, McLellan, Hayes: "Cytosolic and microsomal glutathione S-transferase isoenzymes in normal human liver and intestinal epithelium." in: Gut, Vol. 30, Issue 6, pp. 854-9, 1989
Harrison, Kharbanda, Cunningham, McLellan, Hayes: "Distribution of glutathione S-transferase isoenzymes in human kidney: basis for possible markers of renal injury." in: Journal of clinical pathology, Vol. 42, Issue 6, pp. 624-8, 1989
ImagesProduct Details anti-PDGFB Antibody Target Details PDGFB Application Details Handling References for anti-PDGFB antibody (ABIN115467) back to top