You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our PDGFC Proteins (PDGFC)

Full name:
Platelet-Derived Growth Factor C Proteins (PDGFC)
On www.antibodies-online.com are 18 Platelet-Derived Growth Factor C (PDGFC) Proteins from 9 different suppliers available. Additionally we are shipping PDGFC Antibodies (71) and PDGFC Kits (50) and many more products for this protein. A total of 146 PDGFC products are currently listed.
Synonyms:
1110064L01Rik, AI647969, FALLOTEIN, PDGF-C, SCDGF
list all proteins Gene Name GeneID UniProt
PDGFC 79429 Q9EQX6
PDGFC 56034 Q9NRA1
PDGFC 54635 Q8CI19

Show all synonyms

PDGFC Proteins (PDGFC) by Origin

Select your origin of interest

Top referenced PDGFC Proteins

  1. Human PDGFC Protein expressed in Baculovirus infected Insect Cells - ABIN2002489 : Zwerner, May: PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors. in Oncogene 2001 (PubMed)
    Show all 5 references for ABIN2002489

  2. Mouse (Murine) PDGFC Protein expressed in Human Cells - ABIN2007818 : Li, Pontén, Aase, Karlsson, Abramsson, Uutela, Bäckström, Hellström, Boström, Li, Soriano, Betsholtz, Heldin, Alitalo, Ostman, Eriksson: PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. in Nature cell biology 2000 (PubMed)
    Show all 5 references for ABIN2007818

  3. Cynomolgus PDGFC Protein expressed in Human Cells - ABIN2009737 : Gilbertson, Duff, West, Kelly, Sheppard, Hofstrand, Gao, Shoemaker, Bukowski, Moore, Feldhaus, Humes, Palmer, Hart: Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor. in The Journal of biological chemistry 2001 (PubMed)
    Show all 5 references for ABIN2009737

  4. Human PDGFC Protein expressed in Human Cells - ABIN2002486 : Campbell, Hughes, Gilbertson, Palmer, Holdren, Haran, Odell, Bauer, Ren, Haugen, Yeh, Fausto: Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma. in Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)
    Show all 5 references for ABIN2002486

  5. Human PDGFC Protein expressed in Wheat germ - ABIN1314504 : Okada, Honda, Campbell, Sakai, Yamashita, Takebuchi, Hada, Shirasaki, Takabatake, Nakamura, Sunagozaka, Tanaka, Fausto, Kaneko: Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development. in Cancer research 2012 (PubMed)

More Proteins for PDGFC Interaction Partners

Human Platelet-Derived Growth Factor C (PDGFC) interaction partners

  1. High glucose-mediated induction of PDGF-C via ChREBP (show MLXIPL Proteins) in mesangial cells contributes to the development of glomerular mesangial expansion in diabetes.

  2. PDGF-C up-regulation was mediated by the human embryonic lethal abnormal vision-like protein HuR, which stabilizes the PDGF-C transcript by binding to two predicted AU-rich elements (AREs) in the 3'-untranslated region (3'-UTR).

  3. Concomitant upregulation of PDGF-C with VEGF in Glioblastoma tumor cells.

  4. The results indicate that PDGF-C upregulation and calpain-3 (show CAPN3 Proteins) downregulation are involved in the aggressiveness of malignant melanoma and suggest that modulators of these proteins

  5. Platelet-derived growth factor-C (PDGF-C) induces anti-apoptotic effects on macrophages through Akt (show AKT1 Proteins) and Bad phosphorylation.

  6. Data indicate uPA (plau (show PLAU Proteins)) and PAI1 (Serpine1 (show SERPINE1 Proteins)) were up-regulated in human PDGF-C Tg mice, suggesting that uPA (show PRAP1 Proteins) could be compensating for the loss of tissue-type plasminogen activator (tPA (show PLAT Proteins)) activity in PDGF-C Tg; tpa (show PLAT Proteins) KO mice.

  7. High PDGF-C expression induces progressive fibrosis, chronic inflammation, neoangiogenesis and sinusoidal congestion resulting in hepatocellular carcinoma.

  8. PDGF-C is both angiogenic and a neuronal survival factor, and it is an important component of neurovascular crosstalk. [Review]

  9. Results indicate that the alpha-SMA (show SMN1 Proteins) inducing effect of M2 macrophages is in part mediated by secretion of PGDF-CC.

  10. Single nucleotide polymorphisms in the PDGF-C gene are linked to the development of oral clefts.

Mouse (Murine) Platelet-Derived Growth Factor C (PDGFC) interaction partners

  1. High glucose-mediated induction of PDGF-C via ChREBP (show MLXIPL Proteins) in mesangial cells contributes to the development of glomerular mesangial expansion in diabetes.

  2. PDGF (show PDGFA Proteins)-CC neutralization or deficiency was not associated with preservation or accelerated loss of peritubular capillaries, suggesting no significant pro-angiogenic effects of PDGF (show PDGFA Proteins)-CC during renal fibrosis

  3. heme oxygenase-1 (HMOX1 (show HMOX1 Proteins)) activity is critically required for the vascular protective/survival effect of PDGF (show PDGFA Proteins)-CC.

  4. Studied survival and antiapoptotic effects of PDGF-C on focal retinal lesions in Ccl2 (show CCL2 Proteins)(-/-)/Cx3cr1 (show CX3CR1 Proteins)(-/-) on C57BL/6N [Crb1 (show CRB1 Proteins)(rd8)] (DKO rd8) background mice, a model for progressive and focal retinal degeneration.

  5. loss of FREM1 function promotes epidermal blistering in Fraser syndrome as a consequence of reduced PDGFC activity, in addition to its stabilising role in the basement membrane

  6. Study indicates the role for PDGF-C as a critical regulator of impaired angiogenesis of diabetes.

  7. High PDGF-C expression induces progressive fibrosis, chronic inflammation, neoangiogenesis and sinusoidal congestion resulting in hepatocellular carcinoma.

  8. PDGF-C promotes tumor growth via a growth promoting effect on hepatic stellate cells that is dependent on the presence of functional PAK-2 (show PAK2 Proteins)

  9. Data identified PDGF (show PDGFA Proteins)-CC as an important candidate target gene for antiangiogenic therapy, and PDGF (show PDGFA Proteins)-CC inhibition may be of therapeutic value in treating neovascular diseases.

  10. PDGF-CC is critically required for neuronal survival in both brain and retina. Its neuroprotective effect of PDGF-CC is achieved by regulating GSK3beta phosphorylation and expression.

PDGFC Protein Profile

Protein Summary

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with PDGFC

  • platelet derived growth factor C (PDGFC)
  • platelet derived growth factor C (Pdgfc)
  • platelet-derived growth factor C-like (LOC100350272)
  • platelet-derived growth factor C-like (LOC100515267)
  • platelet-derived growth factor, C polypeptide (Pdgfc)
  • 1110064L01Rik protein
  • AI647969 protein
  • FALLOTEIN protein
  • PDGF-C protein
  • SCDGF protein

Protein level used designations for PDGFC

platelet-derived growth factor C , PDGF-C , VEGF-E , fallotein , platelet-derived growth factor, C polypeptide , rScdfg , spinal cord-derived growth factor , secretory growth factor-like protein , SCDGF

GENE ID SPECIES
736477 Pan troglodytes
79429 Rattus norvegicus
56034 Homo sapiens
482666 Canis lupus familiaris
613787 Bos taurus
100722571 Cavia porcellus
395469 Gallus gallus
101112600 Ovis aries
100350272 Oryctolagus cuniculus
100515267 Sus scrofa
54635 Mus musculus
Selected quality suppliers for PDGFC Proteins (PDGFC)
Did you look for something else?