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Browse our PDGFD Proteins (PDGFD)

Full name:
Platelet Derived Growth Factor D Proteins (PDGFD)
On www.antibodies-online.com are 10 Platelet Derived Growth Factor D (PDGFD) Proteins from 5 different suppliers available. Additionally we are shipping PDGFD Antibodies (60) and PDGFD Kits (47) and many more products for this protein. A total of 124 PDGFD products are currently listed.
Synonyms:
1110003I09Rik, IEGF, PDGFD, rSCDGF-B, SCDGF-B, Scdgfb
list all proteins Gene Name GeneID UniProt
PDGFD 80310 Q9GZP0
PDGFD 66018 Q9EQT1
PDGFD 71785 Q925I7

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PDGFD Proteins (PDGFD) by Origin

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Top referenced PDGFD Proteins

  1. Human PDGFD Protein expressed in Escherichia coli (E. coli) - ABIN1098679 : Bergsten, Uutela, Li, Pietras, Ostman, Heldin, Alitalo, Eriksson: PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor. in Nature cell biology 2001 (PubMed)
    Show all 2 references for ABIN1098679

More Proteins for PDGFD Interaction Partners

Human Platelet Derived Growth Factor D (PDGFD) interaction partners

  1. polymorphism of rs7950273 in the PDGFD gene is not associated with ischaemic stroke in the Chinese Han population

  2. Novel findings reveal a new paradigm in matriptase (show ST14 Proteins) activation involving PDGF-D-specific signal transduction leading to extracellular acidosis.

  3. PDGF-D expression is associated with miR (show MLXIP Proteins)-106a and Twist1 (show TWIST1 Proteins) in HCC (show FAM126A Proteins) patients

  4. PDGF-D is highly expressed by ASCs, where it acts as a potent mitogenic factor.

  5. PDGFD, CDH1 and SLIT2 are upregulated in low grade meningiomas and schwannomas compared with healthy tissue.

  6. PDGF (show PDGFA Proteins)-DD secreted by gastric cancer derived mesenchymal stem cells is capable of promoting gastric cancer cell progression in vitro and in vivo.

  7. Data suggest that targeting platelet-derived growth factor-D as a strategy for endometrial cancer treatment.

  8. Compared with matched normal endometrial cases, PDGF-D was up-regulated in endometrial cancer. Expression of PDGF-D protein, found in 78% of the cases, was associated with nonendometrioid histologic type.

  9. PDGFD-PDGFRbeta signalling is required for human neocortical development and local production of growth factors by radial glia supports the expanded germinal region and progenitor heterogeneity of species with large brains

  10. PDGF-D is highly expressed in gemcitabine resistant (GR) liver neoplasm cells. Furthermore, down-regulation of PDGF-D in GR cells led to partial reversal of the EMT (show ITK Proteins) phenotype.

Mouse (Murine) Platelet Derived Growth Factor D (PDGFD) interaction partners

  1. Inactivation of the Pdgfd gene resulted in a mild phenotype in C57BL/6 mice, and the offspring was viable, fertile and generally in good health.

  2. PDGF-D intensifies fibrogenesis by interfering with the fibrolytic activity of the TIMP-1 (show TIMP1 Proteins)/MMP-2 (show MMP2 Proteins)/MMP (show MMP2 Proteins)-9 (show MMP9 Proteins) system, and PDGF-D signaling is mediated through both PDGF (show PDGFA Proteins)-alpha and -beta receptors.

  3. Radial glia require PDGFD-PDGFRbeta signalling in human but not mouse neocortex

  4. PDGF D represents a potentially promising target for prostate carcinoma treatment resistance in the absence of PTEN function, and warrants further laboratory evaluation and clinical study.

  5. Data indicate that the proteolytic processing of full-length PDGF-D is required for PDGF-D activation of preosteoclasts, and that beta-PDGFR (show PDGFRB Proteins) is present in activated osteoclasts.

  6. identified PDGF (show PDGFA Proteins)-DD as an important target gene for antiangiogenic therapy due to its pleiotropic effects on vascular and non-vascular cells. PDGF (show PDGFA Proteins)-DD inhibition may offer new therapeutic options to treat neovascular diseases

  7. Failure of laminin alpha4-mediated down-regulation of PDGF (show PDGFA Proteins) activity contributes to the progressive renal lesions in this animal model.

  8. These results suggest that PDGF-D induce cellular transformation and promote tumour growth by accelerating the proliferation rate of the tumour cells, and by stimulation of tumour neovascularization.

  9. PDGF-D plays an important role in the pathogenesis of tubulointerstitial injury through binding of PDGF (show PDGFA Proteins)-Rbeta in obstructive ureteral nephropathy

  10. PDGF (show PDGFA Proteins)-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns.

PDGFD Protein Profile

Protein Summary

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene.

Alternative names and synonyms associated with PDGFD

  • platelet derived growth factor D (PDGFD)
  • platelet derived growth factor D (Pdgfd)
  • platelet-derived growth factor, D polypeptide (Pdgfd)
  • 1110003I09Rik protein
  • IEGF protein
  • PDGFD protein
  • rSCDGF-B protein
  • SCDGF-B protein
  • Scdgfb protein

Protein level used designations for PDGFD

platelet derived growth factor D , PDGF-D , platelet-derived growth factor D , platelet-derived growth factor D-like , iris-expressed growth factor , spinal cord derived growth factor B , spinal cord-derived growth factor B , spinal cord-derived growth factor-B , SCDGF-B , platelet-derived growth factor, D polypeptide , spinal-cord derived growth factor-B protein

GENE ID SPECIES
466765 Pan troglodytes
100061488 Equus caballus
100172718 Pongo abelii
100398033 Callithrix jacchus
100586178 Nomascus leucogenys
80310 Homo sapiens
66018 Rattus norvegicus
100008912 Oryctolagus cuniculus
100713757 Cavia porcellus
479460 Canis lupus familiaris
525931 Bos taurus
418978 Gallus gallus
101117784 Ovis aries
71785 Mus musculus
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