anti-Human PDGFRA antibody for Enzyme Immunoassay

Recommended PDGFRA Antibody (supplied by: Log in to see )

Antigen
Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) Antibodies
  • AI115593
  • CD140a
  • Pdgfr-2
  • APDGFR
  • PDGFACE
  • CD140A
  • PDGFR-2
  • PDGFR2
  • RHEPDGFRA
  • PDGFR
  • PDGFR-A
  • platelet derived growth factor receptor alpha
  • platelet derived growth factor receptor, alpha polypeptide
  • platelet-derived growth factor receptor, alpha polypeptide L homeolog
  • platelet-derived growth factor receptor, alpha polypeptide
  • PDGFRA
  • Pdgfra
  • pdgfra.L
Epitope
Tyr754
52
27
20
17
15
15
15
15
15
14
12
11
11
11
11
10
10
9
9
8
7
7
6
6
6
5
5
5
5
5
5
4
4
4
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
482
256
160
7
6
6
6
6
4
3
3
3
2
2
1
1
1
1
Host
Rabbit
357
150
49
3
1
Clonality
Polyclonal
Conjugate
This PDGFRA antibody is un-conjugated
36
31
31
26
22
14
13
12
7
7
7
7
6
5
5
5
5
5
5
5
5
5
5
5
3
3
3
2
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
326
195
194
134
110
67
48
44
15
14
12
9
8
4
3
2
1
1
1
1
1
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Catalog No. ABIN359914
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN359908 EIA IHC (p) WB Rabbit Ig Tyr720 Log in to see Polyclonal 2
1 ABIN359912 EIA IHC (p) WB Rabbit Ig Tyr768 Log in to see Polyclonal 5
1 ABIN359906 EIA IHC (p) Rabbit Ig C-Term Log in to see Polyclonal 5
1 ABIN359910 EIA IHC (p) WB Rabbit Ig Tyr762 Log in to see Polyclonal 2
1 ABIN5611421 EIA IHC (p) Rabbit IgG C-Term Log in to see Polyclonal
1 ABIN372897 EIA IHC (p) WB Rabbit IgG C-Term Log in to see Polyclonal
1 ABIN303439 EIA IHC (p) Rabbit AA 1063-1077 Log in to see Polyclonal
1 ABIN110689 EIA IHC (p) WB Mouse IgG1 Extracellular Domain Log in to see 57-20 (35248)

General

Antigen Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) Antibodies
Epitope Tyr754
(52), (27), (20), (17), (15), (15), (15), (15), (15), (14), (12), (11), (11), (11), (11), (10), (10), (9), (9), (8), (7), (7), (6), (6), (6), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(482), (256), (160), (7), (6), (6), (6), (6), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1)
Host Rabbit
(357), (150), (49), (3), (1)
Clonality
Polyclonal
Conjugate This PDGFRA antibody is un-conjugated
(36), (31), (31), (26), (22), (14), (13), (12), (7), (7), (7), (7), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (3), (3), (3), (2), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(326), (195), (194), (134), (110), (67), (48), (44), (15), (14), (12), (9), (8), (4), (3), (2), (1), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-PDGFRA Antibody

Target Details PDGFRA Application Details Handling References for anti-PDGFRA antibody (ABIN359914) Images
Specificity This antibody reacts to PDGFRA.
Purification Protein A column, followed by peptide affinity purification
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y754 of human PDGFRA.
Isotype Ig

Target Details PDGFRA

Product Details anti-PDGFRA Antibody Application Details Handling References for anti-PDGFRA antibody (ABIN359914) Images back to top
Antigen
Alternative Name CD140a / PDGFRA (PDGFRA Antibody Abstract)
Background PDGFRA is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.Synonyms: Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, PDGF Receptor alpha, PDGF-R-alpha
Gene ID 5156, 9606
UniProt P16234
Research Area CD Antigens, Surface Receptors of Immune Cells, Growth Factors
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Platelet-derived growth Factor Receptor Signaling

Application Details

Product Details anti-PDGFRA Antibody Target Details PDGFRA Handling References for anti-PDGFRA antibody (ABIN359914) Images back to top
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50. Immunofluorescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-PDGFRA Antibody Target Details PDGFRA Application Details References for anti-PDGFRA antibody (ABIN359914) Images back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

References for anti-PDGFRA antibody (ABIN359914)

Product Details anti-PDGFRA Antibody Target Details PDGFRA Application Details Handling Images back to top
Background publications

Chen, Wang, Huang, Liu: "[Experimental study on effects of shengmai injection: enhancing 5-FU anti-tumor efficacy and reducing its toxicity]." in: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, Vol. 3, Issue 6, pp. 476-9, 2005

Wilczynski, Chen, Chen, Howell, Shively, Alberts: "Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers." in: Human pathology, Vol. 36, Issue 3, pp. 242-9, 2005

Debiec-Rychter, Cools, Dumez, Sciot, Stul, Mentens, Vranckx, Wasag, Prenen, Roesel, Hagemeijer, Van Oosterom, Marynen: "Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants." in: Gastroenterology, Vol. 128, Issue 2, pp. 270-9, 2005

Sakurai, Hasegawa, Sakuma, Takazawa, Motegi, Nakajima, Saito, Fukayama, Shimoda: "Myxoid epithelioid gastrointestinal stromal tumor (GIST) with mast cell infiltrations: a subtype of GIST with mutations of platelet-derived growth factor receptor alpha gene." in: Human pathology, Vol. 35, Issue 10, pp. 1223-30, 2004

Subramanian, West, Corless, Ou, Rubin, Chu, Leung, Yuen, Zhu, Hernandez-Boussard, Montgomery, Nielsen, Patel, Goldblum, Heinrich, Fletcher, van de Rijn: "Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles." in: Oncogene, Vol. 23, Issue 47, pp. 7780-90, 2004

Images

Product Details anti-PDGFRA Antibody Target Details PDGFRA Application Details Handling References for anti-PDGFRA antibody (ABIN359914) back to top
Supplier Images
 image for anti-Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) (Tyr754) antibody (ABIN359914) anti-Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) (Tyr754) antibody
 image for anti-Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) (Tyr754) antibody (ABIN359914) anti-Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) (Tyr754) antibody (Image 2)