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anti-Human PDGFRA antibody for Enzyme Immunoassay

Recommended PDGFRA Antibody (supplied by: Log in to see )

Antigen
Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) Antibodies
  • AI115593
  • APDGFR
  • CD140A
  • CD140a
  • PDGFACE
  • PDGFR
  • PDGFR-2
  • Pdgfr-2
  • PDGFR-A
  • PDGFR2
  • RHEPDGFRA
Epitope
C-Term
52
25
19
18
18
18
16
16
15
14
14
14
14
12
11
11
9
7
6
5
5
5
5
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
436
206
138
4
3
3
3
3
2
1
1
1
1
1
1
Host
Rabbit
343
115
35
4
1
Clonality
Polyclonal
Conjugate
This PDGFRA antibody is un-conjugated
32
28
23
22
20
14
11
10
9
6
5
5
5
5
5
5
4
4
3
3
3
3
3
3
2
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
291
198
171
116
76
62
52
43
18
14
12
12
8
4
3
1
1
1
1
Supplier
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Catalog No. ABIN359906
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.00088638917 ABIN359910 EIA IHC (p) WB Rabbit Ig Tyr762 Log in to see Polyclonal 2
0.00088638917 ABIN359914 EIA IF IHC (p) WB Rabbit Ig Tyr754 Log in to see Polyclonal 5
0.00088638917 ABIN359908 EIA IHC (p) WB Rabbit Ig Tyr720 Log in to see Polyclonal 2
0.00088638917 ABIN359912 EIA IHC (p) WB Rabbit Ig Tyr768 Log in to see Polyclonal 5
0.00088638917 ABIN372491 EIA IHC (p) Rabbit IgG C-Term Log in to see Polyclonal
0.00088638917 ABIN372897 EIA IHC (p) WB Rabbit IgG C-Term Log in to see Polyclonal
0.00088638917 ABIN303439 EIA IHC (p) Rabbit AA 1063-1077 Log in to see Polyclonal
0.00088638917 ABIN110689 EIA IHC (p) WB Mouse IgG1 Extracellular Domain Log in to see 57-20 (35248)

Top referenced anti-PDGFRA antibody for Enzyme Immunoassay

  • Human Polyclonal PDGFRA Primary Antibody for EIA, IHC (p) - ABIN359906 (5 Publications): Cools, DeAngelo, Gotlib, Stover, Legare, Cortes, Kutok, Clark, Galinsky, Griffin, Cross, Tefferi, Malone, Alam, Schrier, Schmid, Rose, Vandenberghe, Verhoef, Boogaerts, Wlodarska, Kantarjian, Marynen et al.: A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. ... in The New England journal of medicine 2003 (PubMed)

  • Human Polyclonal PDGFRA Primary Antibody for EIA, IHC (p) - ABIN359910 (2 Publications): Chen, Wang, Huang, Liu: [Experimental study on effects of shengmai injection: enhancing 5-FU anti-tumor efficacy and reducing its toxicity]. in Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 2005 (PubMed)

  • Human Polyclonal PDGFRA Primary Antibody for EIA, IF - ABIN359914 (5 Publications): Wilczynski, Chen, Chen, Howell, Shively, Alberts: Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers. in Human pathology 2005 (PubMed)

  • Human Polyclonal PDGFRA Primary Antibody for EIA, IHC (p) - ABIN359912 (5 Publications): Debiec-Rychter, Cools, Dumez, Sciot, Stul, Mentens, Vranckx, Wasag, Prenen, Roesel, Hagemeijer, Van Oosterom, Marynen: Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants. in Gastroenterology 2005 (PubMed)

Similar anti-PDGFRA Antibodies

Application / Reactivity Human
Dot Blot (DB) 14 Antibodies
ELISA 179 Antibodies
Enzyme Immunoassay (EIA) 9 Antibodies
Flow Cytometry (FACS) 82 Antibodies
Functional Studies (Func) 3 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunocytochemistry (ICC) 41 Antibodies
Immunofluorescence (IF) 52 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 62 Antibodies
Immunohistochemistry (IHC) 150 Antibodies
Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)) 1 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 77 Antibodies
Immunoprecipitation (IP) 12 Antibodies
In vitro Assay (in vitro) 12 Antibodies
Neutralization (Neut) 1 Antibodies
Proximity Ligation Assay (PLA) 3 Antibodies

General

Antigen Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) Antibodies
Epitope C-Term
(52), (25), (19), (18), (18), (18), (16), (16), (15), (14), (14), (14), (14), (12), (11), (11), (9), (7), (6), (5), (5), (5), (5), (4), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(436), (206), (138), (4), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Host Rabbit
(343), (115), (35), (4), (1)
Clonality
Polyclonal
Conjugate This PDGFRA antibody is un-conjugated
(32), (28), (23), (22), (20), (14), (11), (10), (9), (6), (5), (5), (5), (5), (5), (5), (4), (4), (3), (3), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(291), (198), (171), (116), (76), (62), (52), (43), (18), (14), (12), (12), (8), (4), (3), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-PDGFRA Antibody

Target Details PDGFRA Application Details Handling References for anti-PDGFRA Antibody (ABIN359906) Images
Specificity This antibody reacts to PDGFRA.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PDGFRA.
Isotype Ig

Target Details PDGFRA

Product Details anti-PDGFRA Antibody Application Details Handling References for anti-PDGFRA Antibody (ABIN359906) Images back to top
Antigen
Alternative Name CD140a / PDGFRA (PDGFRA Antibody Abstract)
Background PDGFRA is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.Synonyms: Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, PDGF Receptor alpha, PDGF-R-alpha
Gene ID 5156, 9606
UniProt P16234
Research Area CD Antigens, Surface Receptors of Immune Cells, Growth Factors
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-PDGFRA Antibody Target Details PDGFRA Handling References for anti-PDGFRA Antibody (ABIN359906) Images back to top
Application Notes ELISA: 1/1,000. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-PDGFRA Antibody Target Details PDGFRA Application Details References for anti-PDGFRA Antibody (ABIN359906) Images back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

References for anti-PDGFRA Antibody (ABIN359906)

Product Details anti-PDGFRA Antibody Target Details PDGFRA Application Details Handling Images back to top
Background publications

Cools, DeAngelo, Gotlib, Stover, Legare, Cortes, Kutok, Clark, Galinsky, Griffin, Cross, Tefferi, Malone, Alam, Schrier, Schmid, Rose, Vandenberghe, Verhoef, Boogaerts, Wlodarska, Kantarjian, Marynen et al.: "A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. ..." in: The New England journal of medicine, Vol. 348, Issue 13, pp. 1201-14, 2003

Heinrich, Corless, Duensing, McGreevey, Chen, Joseph, Singer, Griffith, Haley, Town, Demetri, Fletcher, Fletcher: "PDGFRA activating mutations in gastrointestinal stromal tumors." in: Science (New York, N.Y.), Vol. 299, Issue 5607, pp. 708-10, 2003

Ribom, Andrae, Frielingsdorf, Hartman, Nistér, Smits: "Prognostic value of platelet derived growth factor alpha receptor expression in grade 2 astrocytomas and oligoastrocytomas." in: Journal of neurology, neurosurgery, and psychiatry, Vol. 72, Issue 6, pp. 782-7, 2002

Andrae, Molander, Smits, Funa, Nistér: "Platelet-derived growth factor-B and -C and active alpha-receptors in medulloblastoma cells." in: Biochemical and biophysical research communications, Vol. 296, Issue 3, pp. 604-11, 2002

Kawagishi, Kumabe, Yoshimoto, Yamamoto: "Structure, organization, and transcription units of the human alpha-platelet-derived growth factor receptor gene, PDGFRA." in: Genomics, Vol. 30, Issue 2, pp. 224-32, 1996

Images

Product Details anti-PDGFRA Antibody Target Details PDGFRA Application Details Handling References for anti-PDGFRA Antibody (ABIN359906) back to top
Supplier Images
 image for anti-PDGFRA antibody (Platelet-Derived Growth Factor Receptor, alpha Polypeptide) (C-Term) (ABIN359906) anti-Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) (C-Term) antibody