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These results suggest that immobilized EGF (show EGF ELISA Kits) increases collective keratinocyte displacement via an increase in single-cell migration persistence resulting from altered EGFR (show EGFR ELISA Kits) trafficking and PLCgamma1 activation.
High PLC (show HSPG2 ELISA Kits) gamma expression is associated with breast cancer.
We show that the decrease in PI(4,5)P2 level under non-stimulated conditions inhibits PTEN activity leading to the aberrant activation of the oncoprotein Akt (show AKT1 ELISA Kits). As well as defining a novel mechanism of Akt (show AKT1 ELISA Kits) phosphorylation with important therapeutic consequences, we also demonstrate that differential expression levels of FGFR2 (show FGFR2 ELISA Kits), Plc11 and Grb2 (show GRB2 ELISA Kits) correlate with patient survival
These results indicate that PP1 (show PPA1 ELISA Kits) is recruited to the extracellular calcium-dependent E-cadherin (show CDH1 ELISA Kits)-catenin-PIP5K1a complex in the plasma membrane to activate PIP5K1a, which is required for PLC (show HSPG2 ELISA Kits)-g1 activation leading to keratinocyte differentiation.
FGFR1 (show FGFR1 ELISA Kits) dimers forms a complex with its effector PLCgamma1.
High PLC gamma1 expression is associated with gastric adenocarcinoma.
Report PLCG1 genetic alterations in angiosarcomas.
expression of PLC-gamma1 and PIKE (show AGAP2 ELISA Kits) positively correlated with the tumor differentiation of oral squamous cell carcinoma.
In a transgenic mouse model, PLCgamma1 is the dominant signaling effector by which activation of TrkB (show NTRK2 ELISA Kits) promotes epilepsy.
hsa (show CD24 ELISA Kits)-miR (show MLXIP ELISA Kits)-665 and hsa (show CD24 ELISA Kits)-miR (show MLXIP ELISA Kits)-95 were downregulated in GSRCC but upregulated in intestinal gastric adenocarcinoma, and the relatively differential expression of the miRNAs negatively controlling their target genes, GLI2 (show GLI2 ELISA Kits) and PLCG1
our studies demonstrate that PLCgamma1 is important for pre-TCR mediated signal transduction and pre-T cell development.
Knock-down of PLC-gamma-1 induced foreign body giant cell formation.PLC-gamma-1-deficiency caused a decrease in RUNX1 (show RUNX1 ELISA Kits) and subsequent PU.1 upregulation while subsequent rescue of RUNX1 (show RUNX1 ELISA Kits) in sh-PLC-gamma-1-transfected cells strongly inhibited foreign body giant cell formation.
study shows that PLCgamma1 controls osteoclast numbers via a CSF-1 (show CSF1 ELISA Kits)-dependent DAG/beta-catenin (show CTNNB1 ELISA Kits)/cyclinD1 pathway.
this study shows that PLC-gamma1 contributes to protective activity of LAT (show LAT ELISA Kits) activity in vivo
PLCgamma1 signaling is involved in the formation of neuronal processes for functionally faithful brain development. [review]
FGFR1 (show FGFR1 ELISA Kits)/2 act in concert to recruit and transphosphorylate phospholipase Cgamma1.
platelet activation through GPVI (show GP6 ELISA Kits) and alphaIIbbeta3 utilizes PLCgamma2 (show PLCG2 ELISA Kits) because PLCgamma1 levels are insufficient to support responsiveness, but that PLCgamma1 can restore responsiveness if expressed at levels normally achieved by PLCgamma2 (show PLCG2 ELISA Kits).
foci are polymerized de novo as a result of the T cell receptor (TCR) proximal tyrosine kinase (show TYRO3 ELISA Kits) cascade, and facilitate distal signaling events including PLCgamma1 activation and subsequent cytoplasmic calcium ion elevation
The result indicate that LAT (show LAT ELISA Kits)-PLCg1 interaction is important for controlling IL-6 (show IL6 ELISA Kits) production by T cells and demonstrate a critical role of IL-6 (show IL6 ELISA Kits) in the development of the lymphoproliferative syndrome.
low level of LAT (show LAT ELISA Kits)-PLC-gamma1 interaction was associated with Th2 polarized differentiation, and this may contribute to the etiology of asthma.
This study is the first to indicate that PLC gamma 1 is expressed in bovine adrenal chromaffin cells and has the potential to be activated.
Tyrosine775 is identified as a new, functionally important phosphorylation site on PLC gamma 1; phosphorylation of both Y775 and Y783 is required for PLC gamma 1 activation as measured by antigen receptor-induced Ca2 (show CA2 ELISA Kits)+ flux, NF-AT (show NFATC3 ELISA Kits) and AP-1 (show JUN ELISA Kits) activation.
PLC-gamma1 is regulated via a novel autoinhibitory mechanism involving its carboxy-terminal Src (show SRC ELISA Kits) homology (SH2C) domain.
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
, Phospholipase C-beta1
, phosphoinositide phospholipase C
, phosphoinositide phospholipase C-beta-1
, phospholipase C-I
, phospholipase C-beta-1
, PLC gamma 1
, phospholipase C-gamma-1b
, phospholipase C, gamma 1
, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
, monophosphatidylinositol phosphodiesterase
, phosphatidylinositol phospholipase C
, phosphoinositidase C
, phosphoinositide phospholipase C-gamma-1
, phospholipase C, gamma 1 (formerly subtype 148)
, phospholipase C-148
, phospholipase C-II
, phospholipase C-gamma-1
, triphosphoinositide phosphodiesterase
, cell differentiation and embryonic development