Browse our Phospholipase D2 Proteins (PLD2)

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Phospholipase D2 Proteins (PLD2)
On are 4 Phospholipase D2 (PLD2) Proteins from 2 different suppliers available. Additionally we are shipping Phospholipase D2 Antibodies (57) and Phospholipase D2 Kits (17) and many more products for this protein. A total of 86 Phospholipase D2 products are currently listed.
PLD2, Pldc
list all proteins Gene Name GeneID UniProt
PLD2 5338 O14939
Rat PLD2 PLD2 25097 P70498
PLD2 18806 P97813

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Phospholipase D2 Proteins (PLD2) by Origin

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More Proteins for Phospholipase D2 Interaction Partners

Human Phospholipase D2 (PLD2) interaction partners

  1. Data suggest that elevated membrane tension acts through phospholipase D2 (PLD2) and the mammalian target of rapamycin (show FRAP1 Proteins) complex 2 (mTORC2 (show CRTC2 Proteins)) to limit actin nucleation.

  2. results suggest that the small GTPase (show RACGAP1 Proteins) RalA (show rala Proteins) plays an important role in promoting invagination and trafficking of caveolae, not by potentiating the association between Cav-1 (show CAV1 Proteins) and FilA but by stimulating PLD2-mediated generation of phosphatidic acid.

  3. Suggest PLD expression in high grade serous ovarian carcinoma may have a role in mediating progression to effusions and chemoresistance.

  4. PLD2 functions as a key mediator in the VEGF-mediated angiogenic functions of endothelial cells.

  5. PLD2 protein itself interacts with HIF-1alpha (show HIF1A Proteins), prolyl hydroxylase (PHD (show PDC Proteins)) and VHL (show VHL Proteins) to promote degradation of HIF-1alpha (show HIF1A Proteins) via the proteasomal pathway independent of lipase (show LIPG Proteins) activity.

  6. PLD2-mediated production of phosphatidic acid contributed to the control of EGFR (show EGFR Proteins) exposure to ligand through a multipronged transcriptional and posttranscriptional program during the out-of-control accumulation of EGFR (show EGFR Proteins) signaling in cancer cells.

  7. These results suggest that PLD2 expression in colon cancer cells is up-regulated via HIF1-alpha (show HIF1A Proteins) in response to hypoxic stress and underscores the crucial role of HIF1-alpha (show HIF1A Proteins)-induced PLD2 in tumor growth.

  8. A 3D model of the PLD2 by combining homology and ab initio 3 dimensional structural modeling methods, and docking conformation, is reported.

  9. PLD2 expression regulates formation of Golgi tubules in Hela cells.

  10. Results indicate distinctive roles of phospholipase D PLD1 and PLD2 isoforms in pathological conditions in retinal pigment epithelium (RPE).

Cow (Bovine) Phospholipase D2 (PLD2) interaction partners

  1. Results suggest that PLD2 is the isoform that mediates aldosterone secretion and likely priming.

Mouse (Murine) Phospholipase D2 (PLD2) interaction partners

  1. Pld1-/- and Pld2-/- mice present elevated free fatty acids (FFA) levels and are insulin (show INS Proteins) as well as glucose intolerant. In conclusion, these data suggest that deficiency of PLD1 or PLD2 activity promotes development of overweight and diabetes.

  2. PLD2 functions as a key mediator in the VEGF-mediated angiogenic functions of endothelial cells.

  3. PLD1/2 signaling pathways are involved in mitogenic signaling in astrocytes.

  4. Data show that although phospholipase D PLD1 deficiency impaired Fc epsilon receptor FcepsilonRI-mediated signaling and mast cell function, phospholipase D PLD2 deficiency actually enhanced these pathways.

  5. PLD2 in neutrophils is essential for the pathogenesis of experimental sepsis

  6. The impact of polyunsaturated fatty acid (PUFA) supplementation on phospholipase D (PLD) trafficking and activity in mast cells was investigated.

  7. AQP3 (show AQP3 Proteins) has a pro-differentiative role in epidermal keratinocytes and PLD2 activity is necessary for this effect.

  8. phosphatidic acid and phospholipase D1 and D2 have roles in leukocyte adhesion

  9. PLD1 and PLD2 have roles in platelet alpha-granule secretion

  10. Demonstrate a novel role for endothelial PLD2 in the survival and migration of ECs under hypoxia via the expression of hypoxia-inducible factor-1alpha and in pathological retinal angiogenesis and tumor angiogenesis in vivo.

Pig (Porcine) Phospholipase D2 (PLD2) interaction partners

  1. The results indicate that PKC (show FYN Proteins) could be the final target and an integrator molecule of different signaling pathways triggered by angiotensin II (Ang II), which could explain the sustained activation of Na(+)-ATPase by Ang II (show AGT Proteins).

Phospholipase D2 (PLD2) Protein Profile

Protein Summary

The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Phospholipase D2 (PLD2)

  • phospholipase D2 (PLD2)
  • phospholipase D2 (pld2)
  • phospholipase D2 (CpipJ_CPIJ013122)
  • phospholipase D2 (VDBG_00892)
  • phospholipase D2 (Pld2)
  • PLD2 protein
  • Pldc protein

Protein level used designations for Phospholipase D2 Proteins (PLD2)

phospholipase D2 , phospholipase D2-like , PLD1C , choline phosphatase 2 , hPLD2 , phosphatidylcholine-hydrolyzing phospholipase D2 , PLD 2 , phospholipase D gene 2 , rPLD2 , mPLD2

454454 Pan troglodytes
479473 Canis lupus familiaris
565743 Danio rerio
721573 Macaca mulatta
6045991 Culex quinquefasciatus
9530787 Verticillium alfalfae VaMs.102
100391217 Callithrix jacchus
100457163 Pongo abelii
100477588 Ailuropoda melanoleuca
100601695 Nomascus leucogenys
5338 Homo sapiens
522159 Bos taurus
25097 Rattus norvegicus
18806 Mus musculus
414900 Sus scrofa
100721224 Cavia porcellus
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