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|Antigen||Protein Phosphatase 3, Catalytic Subunit, gamma Isozyme (PPP3CC) Antibodies|
|Epitope||AA 17-45, N-Term Alternatives|
|Conjugate||This PPP3CC antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|3 references available|
|Supplier||Log in to see|
Product Details anti-PPP3CC AntibodyTarget Details PPP3CC Application Details Handling References for anti-PPP3CC Antibody (ABIN954277) Images
|Specificity||This antibody recognizes Human PPP3CC / CALNA3 (N-term).|
|Purification||Protein A column, followed by peptide affinity purification|
|Immunogen||KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of Human PPP3CC|
Target Details PPP3CCProduct Details anti-PPP3CC Antibody Application Details Handling References for anti-PPP3CC Antibody (ABIN954277) Images back to top
|Alternative Name||PPP3CC / CALNA3 (PPP3CC Antibody Abstract)|
|Background||Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha (CALNA1, MIM 114105), calcineurin A-beta (CALNA2, MIM 114106), and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95 % amino acid identity).Synonyms: CAM-PRP catalytic subunit, CNA3, Calcineurin testis-specific catalytic subunit, Calmodulin-dependent calcineurin A subunit gamma isoform, Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform, protein phosphatase 2B catalytic subunit gamma|
|Molecular Weight||58129 Da|
|Pathways||RTK Signaling, WNT Signaling|
Application DetailsProduct Details anti-PPP3CC Antibody Target Details PPP3CC Handling References for anti-PPP3CC Antibody (ABIN954277) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-PPP3CC Antibody Target Details PPP3CC Application Details References for anti-PPP3CC Antibody (ABIN954277) Images back to top
|Buffer||PBS containing 0.09 % (W/V) Sodium Azide as preservative|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
References for anti-PPP3CC Antibody (ABIN954277)Product Details anti-PPP3CC Antibody Target Details PPP3CC Application Details Handling Images back to top
He, Hu, Li et al.: "Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults." in: European journal of applied physiology, Vol. 110, Issue 4, pp. 761-7, 2010 (PubMed).
Saus, Brunet, Armengol et al.: "Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients." in: Journal of psychiatric research, Vol. 44, Issue 14, pp. 971-8, 2010 (PubMed).
Liu, Guo, Zhang et al.: "Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity." in: Obesity (Silver Spring, Md.), Vol. 18, Issue 12, pp. 2339-46, 2010 (PubMed).
ImagesProduct Details anti-PPP3CC Antibody Target Details PPP3CC Application Details Handling References for anti-PPP3CC Antibody (ABIN954277) back to top