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The CnB 5I/5D variation was found to be significantly associated with CAD. The 5-base pair deletion results in increased serum calcineurin levels.
The mRNA expressions of PPP3CB (show PPP3CB ELISA Kits) and MEF2C (show MEF2C ELISA Kits) were significantly up-regulated, and CAMK1 (show CAMK1 ELISA Kits) and PPP3R1 were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB (show PPP3CB ELISA Kits), MEF2C (show MEF2C ELISA Kits) and PLCE1 (show PLCE1 ELISA Kits) compared to aortic valve disease patients
we report that exogenous CnB is taken up by cells in a time- and concentration-dependent manner via clathrin-dependent receptor-mediated internalization. Our findings further confirm that uptake is mediated by the TLR4 (show TLR4 ELISA Kits)/MD2 (show LY96 ELISA Kits) complex together with the co-receptor CD14 (show NDUFA2 ELISA Kits)
CnB is a novel host-derived immunostimulatory factor, having a role as an agonist in monocytes, and specificity in TLR4 (show TLR4 ELISA Kits) signaling through TRAF3 (show TRAF3 ELISA Kits) and TRAF6 (show TRAF6 ELISA Kits), in response to various agonists.
Data (including data from micro-dissected trophoblasts and trophoblastic BeWo cell line) suggest that microRNA-512-3p participates in placental function by targeting PPP3R1, encoding a regulatory subunit of calcineurin B.
Further evidence that specific variations in MAPT (show MAPT ELISA Kits) (rs3785883) and PPP3R1 (rs1868402) are associated with accelerated progression of Alzheimer's disease
Expression level of PPP3R1 and GATA4 (show GATA4 ELISA Kits), and NFATC4 (show NFATC4 ELISA Kits) genes for transcription factors did not differ in studied subgroups of patients.
Pancreatic beta cells lacking Cnb1 fail to express genes revealed to be direct NFAT (show NFATC1 ELISA Kits) targets required for replication, insulin (show INS ELISA Kits) storage, and secretion.
These findings reveal a novel signaling pathway (CnB-CD11b (show ITGAM ELISA Kits)-NF-kappaB (show NFKB1 ELISA Kits)-TRAIL) regulating TRAIL expression and may help to understand the roles of the calcineurin B subunit in the regulation of innate immunity.
CnB M118K fails to enhance the activities of NF-AT and p53 induced by CnA in HeLa-s cells.
global deficiency of catalytic subunit Ppp3cb (show PPP3CB ELISA Kits), and tissue-specific ablation of regulatory subunit Ppp3r1 from skeletal muscle, but not adipose tissue or liver, led to protection from high-fat-diet-induced obesity
data demonstrate that decreasing calcineurin activity in the amygdala increases anxiety-like behaviors and to some extent depression-like behaviors.
Macrophage Wnt (show WNT2 ELISA Kits)-Calcineurin-Flt1 (show FLT1 ELISA Kits) signaling regulates mouse wound angiogenesis and repair.
intact calcineurin/NFAT (show NFATC1 ELISA Kits) signalling is critically required for p53 (show TP53 ELISA Kits) and senescence-associated mechanisms that protect against skin squamous cancer development
Mechanistically, loss of Heart-specific CnB1 reduced expression of key Ca(2 (show CA2 ELISA Kits)+)-handling genes that likely lead to arrhythmia and reduced contractility
Calcineurin B1 is essential for positive selection during thymocyte development.
gene expression of peroxisome proliferator-activated receptor gamma (show PPARG ELISA Kits) coactivator 1alpha and peroxisome proliferator-activated receptor alpha (show PPARA ELISA Kits) was reduced in the hearts of mice with cardiac-specific ablation of the Cn regulatory subunit.
interconnection exists between Notch 1 (show NOTCH1 ELISA Kits) and Calcineurin-NFAT (show NFATC1 ELISA Kits) pathways in keratinocyte growth/differentiation control
The calcineurin/Nfat (show NFATC1 ELISA Kits) pathway controls the morphologic maturation of lungs prior to birth and regulates expression of genes involved in surfactant homeostasis that are critical for adaptation to air breathing.
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
, calcineurin subunit B type 1
, protein phospatase 3 regulatory subunit B alpha isoform type 1
, protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform
, protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)
, calcineurin B, type I (19kDa)
, protein phosphatase 2B regulatory subunit 1
, protein phosphatase 2B regulatory subunit B alpha
, protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)
, calcineurin B
, protein phosphatase 3 regulatory subunit B alpha
, protein phospatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
, protein phospatase 3, regulatory subunit B, alpha isoform,type 1
, protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
, PP2B beta 1