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|Antigen||PTK7 Protein tyrosine Kinase 7 (PTK7) Antibodies|
|Conjugate||This PTK7 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|2 references available|
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Product Details anti-PTK7 AntibodyTarget Details PTK7 Application Details Handling References for anti-PTK7 antibody (ABIN360111) Images
|Specificity||This antibody reacts to CCK4 (PTK7).|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human CCK4.|
Target Details PTK7Product Details anti-PTK7 Antibody Application Details Handling References for anti-PTK7 antibody (ABIN360111) Images back to top
|Alternative Name||PTK7 / CCK4 (PTK7 Antibody Abstract)|
|Background||CCK4 may function as a cell adhesion molecule. Although it belongs to the insuline receptor subfamily of the Tyr protein kinases, it likely lacks the catalytic activity of a tyrosine kinase. It may be connected to the pathophysiology of colon carcinomas and/or may represent a tumor progression marker. This Type I membrane protein is highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes, but weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle, and not in colon. It is also expressed in erythroleukemia cells.Synonyms: CCK-4, Colon carcinoma kinase 4, Tyrosine-protein kinase-like 7|
|Gene ID||5754, 9606|
|Pathways||RTK Signaling, Tube Formation|
Application DetailsProduct Details anti-PTK7 Antibody Target Details PTK7 Handling References for anti-PTK7 antibody (ABIN360111) Images back to top
ELISA: 1/1,000. Western Blot: 1/50 - 1/200. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-PTK7 Antibody Target Details PTK7 Application Details References for anti-PTK7 antibody (ABIN360111) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-PTK7 antibody (ABIN360111)Product Details anti-PTK7 Antibody Target Details PTK7 Application Details Handling Images back to top
Zhang, Li, Martin, Aebersold: "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry." in: Nature biotechnology, Vol. 21, Issue 6, pp. 660-6, 2003
Park, Lee, Lee: "Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG." in: Journal of biochemistry, Vol. 119, Issue 2, pp. 235-9, 1997
ImagesProduct Details anti-PTK7 Antibody Target Details PTK7 Application Details Handling References for anti-PTK7 antibody (ABIN360111) back to top