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Rac1 and Rac2 have critical roles in skeletal metabolism.
Data indicate that cytosol-to-membrane translocation of the Nox regulatory subunit p47(phox) and the small GTPase (show RACGAP1 ELISA Kits) Rac1/2 was increased in vessels from db/db (show LEPR ELISA Kits) mice compared with db/+ mice, an effect blunted by atorvastatin.
Rac2 GTPase (show RACGAP1 ELISA Kits) is activated downstream of alpha4beta1 integrin and the MCSF (show CSF1 ELISA Kits) receptor to control tumor growth, metastasis and macrophage differentiation.
Rac2-deficient animals have higher rates of mortality in pulmonary fibrosis.
the levels of beta-catenin (show CTNNB1 ELISA Kits) were reduced and not able to prevent the negative effect of Rac2 on PLD2 (show PLD2 ELISA Kits) activity
Data show that the Phospholipase D2 (PLD2 (show PLD2 ELISA Kits))-GTPase (show RACGAP1 ELISA Kits) Rac2 protein-protein interaction is sufficient for the guanine nucleotide exchange factor (show ARHGEF12 ELISA Kits) (GEF (show ARHGEF2 ELISA Kits)) function.
Deletion of Rac1 and Rac2 in osteoclasts causes severe osteopetrosis (show CSF1 ELISA Kits).
Using Rac (show AKT1 ELISA Kits) mutants that are defective in their ability to activate NOX2 (show CYBB ELISA Kits), we show that Rac (show AKT1 ELISA Kits) regulates a redox-mediated feedback loop that mediates directional migration of neutrophils.
loss of either Rac1 or Rac2 is sufficient to impair survival and growth of transformed MLL (show MLL ELISA Kits)-AF9 (show MLLT3 ELISA Kits) leukemia
Rac2 is essential for NET formation via pathways involving ROS (show ROS1 ELISA Kits) and NO.
R665W and L845F be referred to as allomorphic rather than hypermorphic mutations of PLCG2 (show PLCG2 ELISA Kits) Rerouting of the transmembrane signals emanating from BCR (show BCR ELISA Kits) and converging on PLCgamma2 (show PLCG2 ELISA Kits) through Rac (show AKT1 ELISA Kits) in ibrutinib-resistant CLL cells may provide novel drug treatment strategies to overcome ibrutinib resistance mediated by PLCG2 (show PLCG2 ELISA Kits) mutations or to prevent its development in ibrutinib-treated CLL patients.
Study showed that RhoA/Rac2 participate in hepatocellular tumorigenesis through their upregulation by AFAP1-AS1.
RAC1/RAC2 and SFK are proximal and essential for phosphatidylinositol 3-kinase (PI3K (show PIK3CA ELISA Kits)) activation in NK cell-mediated direct cytotoxicity against Cryptococcus neoformans.
RAC2 specifically interacted with a set of mitochondrial proteins.
our present analysis reinforces the involvement in ACT of the regulatory NADPH oxidase (show NOX1 ELISA Kits) subunit RAC2 gene variant rs13058338 and, to a lesser extent of the CYBA (show CYBA ELISA Kits) gene variant rs4673.
homozygous loss-of-function RAC2 mutation in 2 patients with early-onset and progressive hypogammaglobulinemia(novel homozygous nonsense mutation in codon 56 (W56X)of RAC2 gene)
p47(phox) and Rac2 accumulate only transiently at the phagosome at the onset of NADPH (show NQO1 ELISA Kits) activity and detach from the phagosome before the end of reactive oxygen species production.
These studies imply functional importance of iNOS (show NOS2 ELISA Kits) and its interaction with Rac2 in pathogen killing by the neutrophils.
findings indicate that a chemokine-controlled pathway, consisting of Galphai2, ELMO1/Dock180, Rac1 and Rac2, regulates the actin cytoskeleton during breast cancer metastasis
Mutations in hematopoiesis-specific Rho GTPases Rac2 and RhoH lead to a wide range of human blood disorders. (Review)
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.
Ras-related C3 botulinum toxin substrate 2
, EN-7 protein
, protein EN-7
, ras-related C3 botulinum toxin substrate 2
, Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2)
, small G protein
, RAS-related C3 botulinum substrate 2
, ras-related protein