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Browse our RASGRF1 Proteins (RASGRF1)

Full name:
Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 Proteins (RASGRF1)
On are 4 Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) Proteins from 3 different suppliers available. Additionally we are shipping RASGRF1 Antibodies (83) and RASGRF1 Kits (7) and many more products for this protein. A total of 98 RASGRF1 products are currently listed.
AI844718, cdc25, CDC25L, CDC25Mm, GNRP, Grf1, GRF55, Grfbeta, H-GRF55, p190, P190-A, p190RhoGEF, PP13187, PPP1R60, Ras-GRF1, rasgrf1
list all proteins Gene Name GeneID UniProt
RASGRF1 995 P30307
RASGRF1 19417 P27671
Rat RASGRF1 RASGRF1 192213 P28818

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RASGRF1 Proteins (RASGRF1) by Origin

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Human Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) interaction partners

  1. Data indicate that nine compounds were identified with Ki values for CDC25A, -B and -C ranging from 0.01 to 4.4 muM.

  2. Impaired RASGRF1/ERK (show EPHB2 Proteins)-mediated GM-CSF (show CSF2 Proteins) response characterizes CARD9 (show CARD9 Proteins) deficiency in French-Canadians.

  3. These miR (show MLXIP Proteins)-142-3p functioned as a tumor suppressor by targeting CDC25C (show CDC25C Proteins).

  4. Carriers of the rs8027411 G allele in the RASGRF1 gene may be at a lower risk of high myopia in Chinese and Japanese populations. (Meta-analysis)

  5. Cdc25C (show CDC25C Proteins) negatively regulates proapoptotic ASK1 (show MAP3K5 Proteins) in a cell cycle-dependent manner and may play a role in G2/M checkpoint-mediated apoptosis.

  6. Recurrent CDC25C (show CDC25C Proteins) mutations drive malignant transformation in familial platelet disorder to acute myelogenous leukaemia.

  7. CDC25C (show CDC25C Proteins) seems important for the phenotype of AML (show RUNX1 Proteins) cells at least for a subset of patients. Many of the identified CDC25 inhibitors show cross-reactivity among the three CDC25 isoforms.

  8. Rasgrf-1 is a novel GEF (show SLC2A4RG Proteins) protein that has a role in BCR (show BCR Proteins) signaling and its overexpression further activates the Ras/Erk/MAPK (show MAPK1 Proteins) pathway in CLL specimens.

  9. In this study, there was no association of the analyzed SNPs located in RASGRF1. GJD2 (show GJD2 Proteins), and ACTC1 (show ACTC1 Proteins) with pathological myopia.

  10. for the first time, we demonstrated that CTD induced G2/M phase arrest via the inhibition of Cdc25c (show CDC25C Proteins) and cyclin A (show CCNA2 Proteins) and induced apoptosis was through death receptor (extrinsic), intrinsic (mitochondria) and ER stress pathways in A375. S2 cells.

Mouse (Murine) Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) interaction partners

  1. Data (including data from studies in knockout mice) suggest mechanisms involving RasGRF1 exist to regulate hypothalamic-pituitary-adrenal axis in early-adolescent females; such mechanisms appear absent in younger/older female or adolescent male mice.

  2. VLDLR (show VLDLR Proteins) requires RasGRF1/CaMKII (show CAMK2G Proteins) to alter dendritic spine formation.

  3. Study suggests a complex role of ERK (show EPHB2 Proteins)-dependent and Ras-GRF1-dependent signaling in corticostriatal plasticity, highlights differences between synaptic mechanisms in naive slices and dopamine-depleted preparations from L-DOPA-treated dyskinetic animals

  4. RasGrf1 is an important upstream component of signal transduction pathways regulating Pttg1 (show PTTG1 Proteins) expression and controlling beta cell development and physiological responses.

  5. CARD9 (show CARD9 Proteins) regulates H-Ras (show HRAS Proteins) activation by linking Ras-GRF1 to H-Ras (show HRAS Proteins), which mediates Dectin-1 (show CLEC7A Proteins)-induced extracellular signal-regulated protein kinase (show CDK7 Proteins) (ERK (show EPHB2 Proteins)) activation and proinflammatory responses when stimulated by their ligands.

  6. GRF1 is expressed in new neurons when GRF1 loss begins to effect neuronal function, promoting late stages of adult neurogenesis. GRF1 is an age-dependent regulator of adult hippocampal neurogenesis and the ability to distinguish closely related contexts.

  7. Data indicate that contextual discrimination involves term potentiation (LTP (show SCP2 Proteins)) promoted by calcium-permeable AMPA (show GRIA3 Proteins)-type glutamate (show GRIN1 Proteins) receptors, RAS-GRF1 and p38 MAP kinase (show MAPK14 Proteins).

  8. Ras-GRF1 and -GRF2 (show RASGRF2 Proteins) may act as adaptors that bind PLCgamma1 (show PLCG1 Proteins) and restrict Ca2 (show CA2 Proteins)+ signalling to the vicinity of focal adhesions, indicating a new role for these GRFs that is required for IL-1 (show IL1A Proteins) induction of the Ras-->ERK (show EPHB2 Proteins) pathway and MMP-3 (show MMP3 Proteins) expression

  9. identified the guanine nucleotide exchange factor Rasgrf1 as a direct Zac1/Plagl1 (show PLAGL1 Proteins) target gene in beta cells

  10. Present RasGRF1-derived peptides displaying both in vitro and in vivo Ras inhibitory properties.

Pig (Porcine) Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) interaction partners

  1. In conclusion, our results indicated that the Rasgrf1 gene shows both species- and tissue-specific variation in imprinted expression.

RASGRF1 Protein Profile

Protein Summary

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alternative names and synonyms associated with RASGRF1

  • Ras protein-specific guanine nucleotide-releasing factor 1 (RASGRF1)
  • si:ch211-234p18.3 (si:ch211-234p18.3)
  • Ras protein-specific guanine nucleotide-releasing factor 1 (rasgrf1)
  • cell division cycle 25C (CDC25C)
  • RAS protein-specific guanine nucleotide-releasing factor 1 (Rasgrf1)
  • Ras protein-specific guanine nucleotide-releasing factor 1 (Rasgrf1)
  • AI844718 protein
  • cdc25 protein
  • CDC25L protein
  • CDC25Mm protein
  • GNRP protein
  • Grf1 protein
  • GRF55 protein
  • Grfbeta protein
  • H-GRF55 protein
  • p190 protein
  • P190-A protein
  • p190RhoGEF protein
  • PP13187 protein
  • PPP1R60 protein
  • Ras-GRF1 protein
  • rasgrf1 protein

Protein level used designations for RASGRF1

Ras protein-specific guanine nucleotide-releasing factor 1 , ras-specific guanine nucleotide-releasing factor 1-like , M-phase inducer phosphatase 3 , dual specificity phosphatase CDC25C , mitosis inducer CDC25 , phosphotyrosine phosphatase , protein phosphatase 1, regulatory subunit 60 , Ras-specific guanine nucleotide-releasing factor, CDC25 homolog , Ras-specific nucleotide exchange factor CDC25 , guanine nucleotide exchange factor , guanine nucleotide-releasing factor 1 , guanine nucleotide-releasing factor, 55 kD , guanine nucleotide-releasing protein , ras-specific guanine nucleotide-releasing factor 1 , GNRP , GRF beta , Ras guanine release factor beta , guanine nucleotide releasing factor 1 , ras-specific nucleotide exchange factor CDC25 , P140 RAS-GRF , ras-GRF1

453575 Pan troglodytes
568885 Danio rerio
100014099 Monodelphis domestica
100050202 Equus caballus
100461675 Pongo abelii
100479998 Ailuropoda melanoleuca
100492267 Xenopus (Silurana) tropicalis
995 Homo sapiens
5923 Homo sapiens
19417 Mus musculus
192213 Rattus norvegicus
494866 Xenopus laevis
488774 Canis lupus familiaris
520039 Bos taurus
415578 Gallus gallus
100157221 Sus scrofa
100731687 Cavia porcellus
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