Browse our RASGRF1 Proteins (RASGRF1)

Full name:
Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 Proteins (RASGRF1)
On are 4 Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) Proteins from 3 different suppliers available. Additionally we are shipping RASGRF1 Antibodies (92) and RASGRF1 Kits (7) and many more products for this protein. A total of 108 RASGRF1 products are currently listed.
AI844718, cdc25, CDC25L, CDC25Mm, GNRP, Grf1, GRF55, Grfbeta, H-GRF55, p190, P190-A, p190RhoGEF, PP13187, PPP1R60, Ras-GRF1, rasgrf1
list all proteins Gene Name GeneID UniProt
RASGRF1 995 P30307
RASGRF1 19417 P27671
Rat RASGRF1 RASGRF1 192213 P28818

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RASGRF1 Proteins (RASGRF1) by Origin

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More Proteins for RASGRF1 Interaction Partners

Human Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) interaction partners

  1. Myelodysplastic syndrome -related P95 (show NBN Proteins) point mutants of SRSF2 (show SRSF2 Proteins) lead to alternative splicing of CDC25C (show CDC25C Proteins) in a manner that is not dependent on the DNA damage response.

  2. The aim of this review is to shed light on the role of four different phosphatases (PTEN, PP2A (show PPP2R4 Proteins), CDC25 and DUSP1 (show DUSP1 Proteins)) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.

  3. Endoplasmic reticulum stress triggers a localized signaling module on the ER surface involving Nox4-dependent calcium mobilization, which directs local Ras activation through ER-associated, calcium-responsive RasGRF.

  4. Data show that TRIB2 (show TRIB2 Proteins)-mediated degradation of CDC25C (show CDC25C Proteins) is associated with lysine-48-linked CDC25C (show CDC25C Proteins) polyubiquitination driven by the TRIB2 (show TRIB2 Proteins) kinase-like domain.

  5. the biology of the activation/deactivation of CDC25 by kinases/phosphatases to maintain the level of CDK (show CDK4 Proteins)-cyclin (show PCNA Proteins) activities and thus the genomic stability

  6. Data show that microRNA miR (show MLXIP Proteins)-137 directly recognized the 3'-UTR (3'-untranslated region) of the RASGRF1 (Ras protein-specific guanine nucleotide-releasing factor 1) transcript and regulated RASGRF1 expression.

  7. the knockdown of CDC25C (show CDC25C Proteins) can reduce both the radiotherapy sensitivity and the proliferation activity of EC9706 cells.

  8. results identify CDC25C (show CDC25C Proteins) as a downstream target of the mutated tyrosine kinase (show TXK Proteins) FLT3 (show FLT3 Proteins)-ITD affecting cell-cycle regulation in a model of AML (show RUNX1 Proteins)

  9. Suggest that the p53-p21-DREAM-CDE/CHR pathway regulates p53-dependent repression of Survivin, CDC25C, and PLK1 in HCT116 cells.

  10. Data indicate that nine compounds were identified with Ki values for CDC25A, -B and -C ranging from 0.01 to 4.4 muM.

Mouse (Murine) Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) interaction partners

  1. Novel mercaptoacetamide-based class II histone deacetylase (show HDAC1 Proteins) inhibitor HDACIW2 treatment regulated the levels of RasGRF1 and p-ERK (show EPHB2 Proteins), and that W2 requires RasGRF1 and ERK (show EPHB2 Proteins) signaling to alter dendritic spine formation, suggesting that W2 regulates dendritic spine formation via a RasGRF1/ERK (show EPHB2 Proteins)-dependent signaling pathway

  2. Data (including data from studies in knockout mice) suggest mechanisms involving RasGRF1 exist to regulate hypothalamic-pituitary-adrenal axis in early-adolescent females; such mechanisms appear absent in younger/older female or adolescent male mice.

  3. VLDLR (show VLDLR Proteins) requires RasGRF1/CaMKII (show CAMK2G Proteins) to alter dendritic spine formation.

  4. Study suggests a complex role of ERK (show EPHB2 Proteins)-dependent and Ras-GRF1-dependent signaling in corticostriatal plasticity, highlights differences between synaptic mechanisms in naive slices and dopamine-depleted preparations from L-DOPA-treated dyskinetic animals

  5. RasGrf1 is an important upstream component of signal transduction pathways regulating Pttg1 (show PTTG1 Proteins) expression and controlling beta cell development and physiological responses.

  6. CARD9 (show CARD9 Proteins) regulates H-Ras (show HRAS Proteins) activation by linking Ras-GRF1 to H-Ras (show HRAS Proteins), which mediates Dectin-1 (show CLEC7A Proteins)-induced extracellular signal-regulated protein kinase (show CDK7 Proteins) (ERK (show EPHB2 Proteins)) activation and proinflammatory responses when stimulated by their ligands.

  7. GRF1 is expressed in new neurons when GRF1 loss begins to effect neuronal function, promoting late stages of adult neurogenesis. GRF1 is an age-dependent regulator of adult hippocampal neurogenesis and the ability to distinguish closely related contexts.

  8. Data indicate that contextual discrimination involves term potentiation (LTP (show SCP2 Proteins)) promoted by calcium-permeable AMPA (show GRIA3 Proteins)-type glutamate (show GRIN1 Proteins) receptors, RAS-GRF1 and p38 MAP kinase (show MAPK14 Proteins).

  9. Ras-GRF1 and -GRF2 (show RASGRF2 Proteins) may act as adaptors that bind PLCgamma1 (show PLCG1 Proteins) and restrict Ca2 (show CA2 Proteins)+ signalling to the vicinity of focal adhesions, indicating a new role for these GRFs that is required for IL-1 (show IL1A Proteins) induction of the Ras-->ERK (show EPHB2 Proteins) pathway and MMP-3 (show MMP3 Proteins) expression

  10. identified the guanine nucleotide exchange factor Rasgrf1 as a direct Zac1/Plagl1 (show PLAGL1 Proteins) target gene in beta cells

Pig (Porcine) Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) interaction partners

  1. In conclusion, our results indicated that the Rasgrf1 gene shows both species- and tissue-specific variation in imprinted expression.

RASGRF1 Protein Profile

Protein Summary

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alternative names and synonyms associated with RASGRF1

  • Ras protein-specific guanine nucleotide-releasing factor 1 (RASGRF1)
  • si:ch211-234p18.3 (si:ch211-234p18.3)
  • Ras protein-specific guanine nucleotide-releasing factor 1 (rasgrf1)
  • cell division cycle 25C (CDC25C)
  • RAS protein-specific guanine nucleotide-releasing factor 1 (Rasgrf1)
  • Ras protein-specific guanine nucleotide-releasing factor 1 (Rasgrf1)
  • AI844718 protein
  • cdc25 protein
  • CDC25L protein
  • CDC25Mm protein
  • GNRP protein
  • Grf1 protein
  • GRF55 protein
  • Grfbeta protein
  • H-GRF55 protein
  • p190 protein
  • P190-A protein
  • p190RhoGEF protein
  • PP13187 protein
  • PPP1R60 protein
  • Ras-GRF1 protein
  • rasgrf1 protein

Protein level used designations for RASGRF1

Ras protein-specific guanine nucleotide-releasing factor 1 , ras-specific guanine nucleotide-releasing factor 1-like , M-phase inducer phosphatase 3 , dual specificity phosphatase CDC25C , mitosis inducer CDC25 , phosphotyrosine phosphatase , protein phosphatase 1, regulatory subunit 60 , Ras-specific guanine nucleotide-releasing factor, CDC25 homolog , Ras-specific nucleotide exchange factor CDC25 , guanine nucleotide exchange factor , guanine nucleotide-releasing factor 1 , guanine nucleotide-releasing factor, 55 kD , guanine nucleotide-releasing protein , ras-specific guanine nucleotide-releasing factor 1 , GNRP , GRF beta , Ras guanine release factor beta , guanine nucleotide releasing factor 1 , ras-specific nucleotide exchange factor CDC25 , P140 RAS-GRF , ras-GRF1

453575 Pan troglodytes
568885 Danio rerio
100014099 Monodelphis domestica
100050202 Equus caballus
100461675 Pongo abelii
100479998 Ailuropoda melanoleuca
100492267 Xenopus (Silurana) tropicalis
995 Homo sapiens
5923 Homo sapiens
19417 Mus musculus
192213 Rattus norvegicus
494866 Xenopus laevis
488774 Canis lupus familiaris
520039 Bos taurus
415578 Gallus gallus
100157221 Sus scrofa
100731687 Cavia porcellus
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