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Human RHEB Protein expressed in Escherichia coli (E. coli) - ABIN666866
Tabancay, Gau, Machado, Uhlmann, Gutmann, Guo, Tamanoi: Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K. in The Journal of biological chemistry 2003
Show all 2 references for ABIN666866
Human RHEB Protein expressed in Baculovirus infected Insect Cells - ABIN2004249
Karbowniczek, Cash, Cheung, Robertson, Astrinidis, Henske: Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent. in The Journal of biological chemistry 2004
By interfering with TSC-Rheb complex, arginine relieves allosteric inhibition of Rheb by TSC. Arginine cooperates with growth factor signaling which further promotes dissociation of TSC2 from lysosomes and activation of mTORC1.
Data show that Rheb/p27 (show PAK2 Proteins) axis induces autophagy-dependent cancer cell survival under stress conditions.
Mutations in the TSC2-RHEB-mTOR (show FRAP1 Proteins) signaling axis may lead to a loss of inhibitory inputs thus conferring a survival advantage to a dividing tumor cell.
Activation of CNTF (show CNTF Proteins)/CNTFRalpha (show CNTFR Proteins) signaling pathway by hRheb(S16H) transduction of dopaminergic neurons
RGS10 (show RGS10 Proteins) could serve in a novel, and previously unknown, role by accelerating the hydrolysis of GTP (show AK3 Proteins) from Rheb in ovarian cancer cells.
In TSC2-deficient angiomyolipoma patient cells, IRF7 (show IRF7 Proteins) is a pivotal factor in the Rheb/mTOR (show FRAP1 Proteins) pathway.
These results establish CAD as a downstream effector of Rheb and suggest a possible role of Rheb in regulating de novo pyrimidine nucleotide synthesis.(Rheb small GTPases, which consist of Rheb1 and Rheb2 (also known as RhebL1 (show RHEBL1 Proteins))
In vitro data indicated that miR (show MLXIP Proteins)-155 suppressed the macrophage-mediated bacterial phagocytosis and intracellular killing of Pseudomonas aeruginosa by targeting Rheb (Ras homolog enriched in brain).
Data indicate that Rheb G63A stimulated phosphorylation of the mTORC1 substrate p70S6 kinase more strongly than wild-type, thus offering a new tool for mammalian target of rapamycin (mTOR (show FRAP1 Proteins)) signaling.
study defines Rheb as a novel physiological regulator of BACE1 (show BACE Proteins) levels and Abeta (show APP Proteins) generation, and the Rheb-BACE1 (show BACE Proteins) circuitry may have a role in brain biology and disease.
EAAT4 (show SLC1A6 Proteins) was downregulated due to the loss of Rheb1 in Purkinje cells; mTORC1 was downregulated and Akt (show AKT1 Proteins) was upregulated in Rheb1 cKO mice, suggesting that mTORC1 and Akt (show AKT1 Proteins) may be related to the downregulation of EAAT4 (show SLC1A6 Proteins); Rheb1 knockout decreased EAAT4 (show SLC1A6 Proteins) currents and slowed down the kinetics of AMPA (show GRIA3 Proteins) currents; Rheb1 deficiency did not affect the morphology of Purkinje cell layer and the development of Purkinje cells
Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.
Rheb activation disrupts neuronal spine synapse formation via syntenin (show SDCBP Proteins) accumulation in tuberous sclerosis complex.
We conclude that in contrast to TORC1 (show CRTC1 Proteins) hyper-activity, cognitive function is not very sensitive to sustained and specific down-regulation of TORC1 (show CRTC1 Proteins) activity.
Rheb protein was mainly detected in apoptotic retinal ganglion cells following light injury.
PDK4 (show PDK4 Proteins) promotes tumorigenesis through activation of the CREB (show CREB1 Proteins)-RHEB-mTORC1 signaling cascade.
The small GTPase (show RACGAP1 Proteins) Rheb is required for spermatogenesis but not oogenesis.
The paper proposed a novel pathway/mechanism involving Rheb/mTORC1/S6K (show RPS6KB1 Proteins) signaling to explain how C2-ceramide impairs insulin (show INS Proteins) signaling via Akt (show AKT1 Proteins) phosphorylation.
whereas rapid adaptation in mTORC1 activity requires Rheb, a second Rheb-independent activation mechanism exists that contributes to cell cycle progression.
miR (show MLXIP Proteins)-155 bound to the 3'-untranslated region of Ras homologue enriched in brain (Rheb), a negative regulator of autophagy, accelerated the process of autophagy and sequential killing of intracellular mycobacteria by suppressing Rheb expression.
This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.
Ras homolog enriched in brain
, RAS-homolog enriched in brain
, ras homolog enriched in brain
, GTP-binding protein rheb
, GTP-binding protein Rheb
, Ras homolog enriched in brain 2