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This study describes the regulation of EMT (show ITK ELISA Kits) in RPE cells by TGF-beta1 (show TGFB1 ELISA Kits)/miR (show MLXIP ELISA Kits)-124/RHOG signaling and suggests that the supplement of miR (show MLXIP ELISA Kits)-124 exogenously would be a valuable therapeutic approach for the prevention or treatment of proliferative vitreoretinopathy.
RhoG is expressed and activated in platelets, plays an important role in GPVI (show GP6 ELISA Kits)-Fc receptor gamma-chain (show FCER1G ELISA Kits) complex-mediated platelet activation, and is critical for thrombus formation in vivo.
several Rho family small GTPases activate PI3K (show PIK3CA ELISA Kits) by an indirect cooperative positive feedback that required a combination of Rac (show AKT1 ELISA Kits), CDC42 (show CDC42 ELISA Kits), and RhoG small GTPase (show RACGAP1 ELISA Kits) activities
The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity.
The activation of RhoG recruits its effector ELMO2 (show ELMO2 ELISA Kits) and a Rac (show AKT1 ELISA Kits) GEF Dock4 (show DOCK4 ELISA Kits) to form a complex with EphA2 (show EPHA2 ELISA Kits) at the tips of cortactin (show CTTN ELISA Kits)-rich protrusions in migrating breast cancer cells.
RhoG function is mediated by signals independent of Rac1 and Cdc42 (show CDC42 ELISA Kits) activation and instead by direct utilization of a subset of common effectors
we show a novel function for the small GTPase (show RACGAP1 ELISA Kits) RhoG on the regulation of the interferon-gamma (show IFNG ELISA Kits) promoter and nuclear factor of activated T cells (NFAT (show NFATC1 ELISA Kits)) gene. RhoG also promotes T-cell spreading on fibronectin (show FN1 ELISA Kits)
C-terminal basic tail of RhoG specifically assists the recruitment of the TrioN-PH domain to specific membrane-bound phospholipids
Results suggest that RhoG contributes to the regulation of Rac1 activity in migrating cells.
RhoG is involved in caveolar trafficking. Such translocation is associated with changes in RhoG GDP/GTP (show AK3 ELISA Kits) levels and is highly dependent on lipid raft integrity and on the function of the GTPase (show RACGAP1 ELISA Kits) dynamin2.
ELMO2 (show ELMO2 ELISA Kits)-RhoG-ILK (show ILK ELISA Kits) complex has a key role in integrin-independent stabilization of the microtubule network in differentiated keratinocytes.
RhoG protein regulates platelet granule secretion and thrombus formation in mice.
Examined the role of RhoG in the invasive behavior of glioblastoma cells; found that depletion of RhoG strongly inhibits activation of the Rac1 GTPase by both HGF and EGF; also RhoG contributes to the formation of lamellipodia and invadopodia.
several Rho family small GTPases activate PI3K by an indirect cooperative positive feedback that required a combination of Rac (show AKT1 ELISA Kits), CDC42 (show CDC42 ELISA Kits), and RhoG small GTPase (show RACGAP1 ELISA Kits) activities
Results indicate that RhoG promotes neural progenitor cell proliferation through PI3K in cortical development.
different biological properties of RhoG and Rac1 can be traced to specific amino acid variations in their switch I, beta2/beta3 hairpin, alpha5 helix, and C-terminal polybasic regions.
In RhoG deficient mice, the development of B and T lymphocytes was unaffected. However, there was an increase in the level of serum IgG1 and IgG2b as well as a mild increase of the humoral immune response to thymus-dependent antigens.
define RhoG as a critical component of G protein-coupled receptor (show GPR34 ELISA Kits)-stimulated signaling cascades in murine neutrophils
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X.
ras homolog gene family, member G (rho G)
, rho-related GTP-binding protein RhoG
, aplysia ras-related homolog G (RhoG)
, ras homolog G (RhoG)
, sid 10750