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|Antigen||Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) Antibodies|
|Epitope||AA 24-403 Alternatives|
|Conjugate||This ROR1 antibody is un-conjugated Alternatives|
Cytometry by Time of Flight (CyTOF), Flow Cytometry (FACS), Simple Western (SimWes), Western Blotting (WB)
|4 references available|
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Product Details anti-ROR1 AntibodyTarget Details ROR1 Application Details Handling References for anti-ROR1 antibody (ABIN4899817) Images
|Specificity||Detects human ROR1 in direct ELISAs and Western blots. In direct ELISAs, less than 5 % cross-reactivity with recombinant human ROR2 is observed.|
|Sterility||0.2 μm filtered|
|Immunogen||Mouse myeloma cell line NS0-derived recombinant human ROR1, Ala24-Glu403, Accession # Q01973|
Target Details ROR1Product Details anti-ROR1 Antibody Application Details Handling References for anti-ROR1 antibody (ABIN4899817) Images back to top
|Alternative Name||ROR1 (ROR1 Antibody Abstract)|
|Background||Alternative Names: EC 126.96.36.199, MGC99659, neurotrophic tyrosine kinase receptor-related 1, Neurotrophic tyrosine kinase, receptor-related 1, NTRKR1, NTRKR1dJ537F10.1, receptor tyrosine kinase-like orphan receptor 1, tyrosine-protein kinase transmembrane receptor ROR1|
|Research Area||Tyrosine Kinases, Neurology|
|Pathways||RTK Signaling, WNT Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha|
Application DetailsProduct Details anti-ROR1 Antibody Target Details ROR1 Handling References for anti-ROR1 antibody (ABIN4899817) Images back to top
Western Blot 1 μg/mL
Simple Western 25 μg/mL
Flow Cytometry 0.25 μg/10^6 cells
|Restrictions||For Research Use only|
HandlingProduct Details anti-ROR1 Antibody Target Details ROR1 Application Details References for anti-ROR1 antibody (ABIN4899817) Images back to top
|Reconstitution||Reconstitute at 0.2 mg/mL in sterile PBS.|
|Buffer||Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.|
|Storage||4 °C,-20 °C,-80 °C|
|Storage Comment||Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20°C to -70°C as supplied. 1 month,2°C to 8°C under sterile conditions after reconstitution. 6 months,-20°C to -70°C under sterile conditions after reconstitution.|
|Expiry Date||12 months|
References for anti-ROR1 antibody (ABIN4899817)Product Details anti-ROR1 Antibody Target Details ROR1 Application Details Handling Images back to top
|Product cited in:||
Henry, Llamosas, Knipprath-Meszaros, Schoetzau, Obermann, Fuenfschilling, Caduff, Fink, Hacker, Ward, Heinzelmann-Schwarz, Ford: "Targeting the ROR1 and ROR2 receptors in epithelial ovarian cancer inhibits cell migration and invasion." in: Oncotarget, Vol. 6, Issue 37, pp. 40310-26, 2015 Method employed by authors: Western Blotting (WB) (Sample species: Human).
Gentile, Lazzari, Benvenuti, Trusolino, Comoglio: "Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis." in: Cancer research, Vol. 71, Issue 8, pp. 3132-41, 2011 Method employed by authors: Immunoprecipitation (IP) (Sample species: Human).
Hudecek, Schmitt, Baskar, Lupo-Stanghellini, Nishida, Yamamoto, Bleakley, Turtle, Chang, Greisman, Wood, Maloney, Jensen, Rader, Riddell: "The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor." in: Blood, Vol. 116, Issue 22, pp. 4532-41, 2010 Method employed by authors: Flow Cytometry (FACS) (Sample species: Human).
Baskar, Kwong, Hofer, Levy, Kennedy, Lee, Staudt, Wilson, Wiestner, Rader: "Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 2, pp. 396-404, 2008 Method employed by authors: Flow Cytometry (FACS) (Sample species: Human).
ImagesProduct Details anti-ROR1 Antibody Target Details ROR1 Application Details Handling References for anti-ROR1 antibody (ABIN4899817) back to top