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|Application / Reactivity||Human|
|Enzyme Immunoassay (EIA)||4 Antibodies|
|Flow Cytometry (FACS)||34 Antibodies|
|Immunocytochemistry (ICC)||3 Antibodies|
|Immunofluorescence (IF)||11 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||1 Antibodies|
|Immunohistochemistry (IHC)||11 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||13 Antibodies|
|Immunoprecipitation (IP)||3 Antibodies|
|Intracellular Flow Cytometry (ICFC)||2 Antibodies|
|Western Blotting (WB)||74 Antibodies|
|Antigen||Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) Antibodies|
|Conjugate||This ROR1 antibody is conjugated to APC Alternatives|
Flow Cytometry (FACS), Immunofluorescence (IF), Intracellular Flow Cytometry (ICFC)
|7 references available|
|Supplier||Log in to see|
Product Details anti-ROR1 AntibodyTarget Details ROR1 Application Details Handling References for anti-ROR1 Antibody (ABIN2658385) Images
|Purification||The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.|
Target Details ROR1Product Details anti-ROR1 Antibody Application Details Handling References for anti-ROR1 Antibody (ABIN2658385) Images back to top
|Alternative Name||ROR1 (ROR1 Antibody Abstract)|
|Background||ROR1, also known as NTRKR1, is a type I transmembrane protein and member of the ROR subfamily of surface receptors. ROR1 consists of one frizzled domain, one Ig-like C2-type domain, one kringle domain, and one kinase domain with no catalytic activity. ROR1 is expressed on embryonic tissue, in the central nervous system and on some cancer cells, and is used as a marker for B-cell chronic lymphocytic leukemia. Wnt5a has been identified as a ligand for ROR1.|
|Research Area||Neurology, Tyrosine Kinases|
|Pathways||RTK Signaling, WNT Signaling, Nuclear Receptor Transcription Pathway|
Application DetailsProduct Details anti-ROR1 Antibody Target Details ROR1 Handling References for anti-ROR1 Antibody (ABIN2658385) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-ROR1 Antibody Target Details ROR1 Application Details References for anti-ROR1 Antibody (ABIN2658385) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-ROR1 Antibody (ABIN2658385)Product Details anti-ROR1 Antibody Target Details ROR1 Application Details Handling Images back to top
Dave, Anver, Butcher et al.: "Restricted cell surface expression of receptor tyrosine kinase ROR1 in pediatric B-lineage acute lymphoblastic leukemia suggests targetability with therapeutic monoclonal antibodies." in: PLoS ONE, Vol. 7, Issue 12, pp. e52655, 2013 (PubMed).
Bicocca, Chang, Masouleh et al.: "Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia." in: Cancer cell, Vol. 22, Issue 5, pp. 656-67, 2012 (PubMed).
Baskar, Wiestner, Wilson et al.: "Targeting malignant B cells with an immunotoxin against ROR1." in: mAbs, Vol. 4, Issue 3, pp. 349-61, 2012 (PubMed).
Zhang, Chen, Cui et al.: "ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth." in: PLoS ONE, Vol. 7, Issue 3, pp. e31127, 2012 (PubMed).
Yang, Baskar, Kwong et al.: "Therapeutic potential and challenges of targeting receptor tyrosine kinase ROR1 with monoclonal antibodies in B-cell malignancies." in: PLoS ONE, Vol. 6, Issue 6, pp. e21018, 2011 (PubMed).
Uhrmacher, Schmidt, Erdfelder et al.: "Use of the receptor tyrosine kinase-like orphan receptor 1 (ROR1) as a diagnostic tool in chronic lymphocytic leukemia (CLL)." in: Leukemia research, Vol. 35, Issue 10, pp. 1360-6, 2011 (PubMed).
Grumolato, Liu, Mong et al.: "Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors." in: Genes & development, Vol. 24, Issue 22, pp. 2517-30, 2010 (PubMed).
ImagesProduct Details anti-ROR1 Antibody Target Details ROR1 Application Details Handling References for anti-ROR1 Antibody (ABIN2658385) back to top