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anti-Human ROR1 antibody for Immunohistochemistry (Frozen Sections)

Recommended ROR1 Antibody (supplied by: Log in to see )

Antigen
Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) Antibodies
  • 2810404D04Rik
  • 9530021D13Rik
  • dJ537F10.1
  • mRor1
  • nmf267
  • Nr1f1
  • NTRKR1
  • Ntrkr1
  • RGD1559469
  • ROR1
  • ROR2
  • ROR3
  • sg
  • staggerer
  • tmgc26
Reactivity
Human
104
20
14
2
1
1
1
1
1
1
1
Host
Mouse
75
28
7
Clonality
Monoclonal
Conjugate
This ROR1 antibody is un-conjugated
8
8
5
4
4
2
2
2
2
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
78
54
33
13
11
11
4
4
2
2
2
1
Supplier
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Catalog No. ABIN2689893
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008821484 ABIN1860463 ICC IHC (fro) IHC (p) ELISA WB Rabbit IgG AA 540-795 Log in to see Polyclonal

Top referenced anti-ROR1 antibody for Immunohistochemistry (Frozen Sections)

Similar anti-ROR1 Antibodies

Application / Reactivity Human
ELISA 50 Antibodies
Enzyme Immunoassay (EIA) 4 Antibodies
Flow Cytometry (FACS) 34 Antibodies
Immunocytochemistry (ICC) 3 Antibodies
Immunofluorescence (IF) 11 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 1 Antibodies
Immunohistochemistry (IHC) 11 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 13 Antibodies
Immunoprecipitation (IP) 3 Antibodies
Intracellular Flow Cytometry (ICFC) 2 Antibodies
Western Blotting (WB) 74 Antibodies

General

Antigen Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) Antibodies
Reactivity Human
(104), (20), (14), (2), (1), (1), (1), (1), (1), (1), (1)
Host Mouse
(75), (28), (7)
Clonality (Clone)
Monoclonal   ( )
Conjugate This ROR1 antibody is un-conjugated
(8), (8), (5), (4), (4), (2), (2), (2), (2), (1)
Application Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
(78), (54), (33), (13), (11), (11), (4), (4), (2), (2), (2), (1)
Pubmed 5 references available
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Product Details anti-ROR1 Antibody

Target Details ROR1 Application Details Handling References for anti-ROR1 Antibody (ABIN2689893) Images
Brand BD Pharmingen™
Characteristics The 4A5 monoclonal antibody binds to the glycosylated type I membrane protein ROR1 (Receptor-tyrosine-kinase-like Orphan Receptor 1). The ROR1 and ROR2 related proteins are highly conserved evolutionarily and are primarily expressed during embryogenesis. ROR1 is not expressed on normal peripheral blood lymphocytes. ROR1 is similar to tropomyosin receptor kinase (Trk family) neurotropic receptors and shares a cysteine-rich domain with Frizzled receptors for Wnt-family signaling proteins, which are involved in the regulation of embryogenesis and carcinogenesis. Furthermore, there is mounting evidence that aberrant ROR1 expression contributes to human malignancy. ROR1 expression in human embryonal carcinoma cells. Human NCCIT cells (ATCC CRL-2073) were stained with either Purified Mouse IgG2b κ Isotype Control (Cat. No. 555740, dashed line histogram) or Purified Mouse Anti-Human ROR1 (Cat. No. 564464, solid-line histogram) monoclonal antibodies. The second-step reagent was PE Goat Anti-Mouse Ig (Multiple Adsorption) (Cat. No. 550589). The fluorescence histograms were derived from events with the forward and side light-scatter characteristics of viable NCCIT cells. Flow cytometry was performed using a BD LSRFortessa™ Flow Cytometer System.

BD Pharmingen™ Purified Mouse Anti-Human ROR1 - Purified - Clone 4A5 - Isotype Mouse IgG2b, κ - Reactivity Hu - 0.1 mg
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Human ROR1 cDNA
Clone 4A5
Isotype IgG2b, kappa

Target Details ROR1

Product Details anti-ROR1 Antibody Application Details Handling References for anti-ROR1 Antibody (ABIN2689893) Images back to top
Antigen
Alternative Name ROR1 (ROR1 Antibody Abstract)
Background Synonyms: Neurotrophic tyrosine kinase, receptor-related 1, NTRKR1
Research Area Neurology, Tyrosine Kinases
Pathways RTK Signaling, WNT Signaling, Nuclear Receptor Transcription Pathway

Application Details

Product Details anti-ROR1 Antibody Target Details ROR1 Handling References for anti-ROR1 Antibody (ABIN2689893) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-ROR1 Antibody Target Details ROR1 Application Details References for anti-ROR1 Antibody (ABIN2689893) Images back to top
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.

References for anti-ROR1 Antibody (ABIN2689893)

Product Details anti-ROR1 Antibody Target Details ROR1 Application Details Handling Images back to top
Product cited in:

Cui, Zhang, Chen, Yu, Widhopf, Fecteau, Rassenti, Kipps: "Targeting ROR1 inhibits epithelial-mesenchymal transition and metastasis." in: Cancer research, Vol. 73, Issue 12, pp. 3649-60, 2013

Zhang, Chen, Wang-Rodriguez, Zhang, Cui, Frankel, Wu, Kipps: "The onco-embryonic antigen ROR1 is expressed by a variety of human cancers." in: The American journal of pathology, Vol. 181, Issue 6, pp. 1903-10, 2012

Zhang, Chen, Cui, Chuang, Yu, Wang-Rodriguez, Tang, Chen, Basak, Kipps: "ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth." in: PLoS ONE, Vol. 7, Issue 3, pp. e31127, 2012

Broome, Rassenti, Wang, Meyer, Kipps: "ROR1 is expressed on hematogones (non-neoplastic human B-lymphocyte precursors) and a minority of precursor-B acute lymphoblastic leukemia." in: Leukemia research, Vol. 35, Issue 10, pp. 1390-4, 2011

Fukuda, Chen, Endo, Tang, Lu, Castro, Widhopf, Rassenti, Cantwell, Prussak, Carson, Kipps: "Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 8, pp. 3047-52, 2008