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anti-Human ROR1 antibody for Immunoprecipitation

Recommended ROR1 Antibody (supplied by: Log in to see )

Antigen
Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) Antibodies
  • 2810404D04Rik
  • 9530021D13Rik
  • dJ537F10.1
  • mRor1
  • nmf267
  • Nr1f1
  • NTRKR1
  • Ntrkr1
  • RGD1559469
  • ROR1
  • ROR2
  • ROR3
  • sg
  • staggerer
  • tmgc26
Reactivity
Human
109
20
14
2
1
1
1
1
1
1
1
Host
Mouse
77
30
8
Clonality
Monoclonal
Conjugate
This ROR1 antibody is conjugated to PE-Cy7
8
8
5
4
4
2
2
2
1
1
Application
Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA
82
55
33
15
12
10
5
4
3
2
2
1
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Catalog No. ABIN2659390
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008945949 ABIN2689893 IHC (fro) FACS IHC (p) IP Mouse IgG2b, kappa Log in to see 4A5 5
0.0008945949 ABIN2659391 FACS IP IHC ELISA PE-Cy7 Mouse IgG1 kappa Log in to see 2A2 7

Top referenced anti-ROR1 antibody for Immunoprecipitation

Similar anti-ROR1 Antibodies

Application / Reactivity Human
ELISA 52 Antibodies
Enzyme Immunoassay (EIA) 4 Antibodies
Flow Cytometry (FACS) 34 Antibodies
Immunocytochemistry (ICC) 4 Antibodies
Immunofluorescence (IF) 12 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 1 Antibodies
Immunohistochemistry (IHC) 11 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 14 Antibodies
Immunoprecipitation (IP) 3 Antibodies
Intracellular Flow Cytometry (ICFC) 2 Antibodies
Western Blotting (WB) 78 Antibodies

General

Antigen Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) Antibodies
Reactivity Human
(109), (20), (14), (2), (1), (1), (1), (1), (1), (1), (1)
Host Mouse
(77), (30), (8)
Clonality (Clone)
Monoclonal   ( )
Conjugate This ROR1 antibody is conjugated to PE-Cy7
(8), (8), (5), (4), (4), (2), (2), (2), (1), (1)
Application Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA
(82), (55), (33), (15), (12), (10), (5), (4), (3), (2), (2), (1)
Pubmed 7 references available
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Product Details anti-ROR1 Antibody

Target Details ROR1 Application Details Handling References for anti-ROR1 Antibody (ABIN2659390) Images
Purification The antibody was purified by affinity chromatography and conjugated with PE/Cy7 under optimal conditions. The solution is free of unconjugated PE/Cy7 and unconjugated antibody.
Clone 2A2
Isotype IgG1 kappa

Target Details ROR1

Product Details anti-ROR1 Antibody Application Details Handling References for anti-ROR1 Antibody (ABIN2659390) Images back to top
Antigen
Alternative Name ROR1 (ROR1 Antibody Abstract)
Background ROR1, also known as NTRKR1, is a type I transmembrane protein and member of the ROR subfamily of surface receptors. ROR1 consists of one frizzled domain, one Ig-like C2-type domain, one kringle domain, and one kinase domain with no catalytic activity. ROR1 is expressed on embryonic tissue, in the central nervous system and on some cancer cells, and is used as a marker for B-cell chronic lymphocytic leukemia. Wnt5a has been identified as a ligand for ROR1.
Research Area Neurology, Tyrosine Kinases
Pathways RTK Signaling, WNT Signaling, Nuclear Receptor Transcription Pathway

Application Details

Product Details anti-ROR1 Antibody Target Details ROR1 Handling References for anti-ROR1 Antibody (ABIN2659390) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-ROR1 Antibody Target Details ROR1 Application Details References for anti-ROR1 Antibody (ABIN2659390) Images back to top
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-ROR1 Antibody (ABIN2659390)

Product Details anti-ROR1 Antibody Target Details ROR1 Application Details Handling Images back to top
Background publications

Dave, Anver, Butcher, Brown, Khan, Wayne, Baskar, Rader: "Restricted cell surface expression of receptor tyrosine kinase ROR1 in pediatric B-lineage acute lymphoblastic leukemia suggests targetability with therapeutic monoclonal antibodies." in: PLoS ONE, Vol. 7, Issue 12, pp. e52655, 2013

Bicocca, Chang, Masouleh, Muschen, Loriaux, Druker, Tyner: "Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia." in: Cancer cell, Vol. 22, Issue 5, pp. 656-67, 2012

Zhang, Chen, Cui, Chuang, Yu, Wang-Rodriguez, Tang, Chen, Basak, Kipps: "ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth." in: PLoS ONE, Vol. 7, Issue 3, pp. e31127, 2012

Baskar, Wiestner, Wilson, Pastan, Rader: "Targeting malignant B cells with an immunotoxin against ROR1." in: mAbs, Vol. 4, Issue 3, pp. 349-61, 2012

Uhrmacher, Schmidt, Erdfelder, Poll-Wolbeck, Gehrke, Hallek, Kreuzer: "Use of the receptor tyrosine kinase-like orphan receptor 1 (ROR1) as a diagnostic tool in chronic lymphocytic leukemia (CLL)." in: Leukemia research, Vol. 35, Issue 10, pp. 1360-6, 2011

Yang, Baskar, Kwong, Kennedy, Wiestner, Rader: "Therapeutic potential and challenges of targeting receptor tyrosine kinase ROR1 with monoclonal antibodies in B-cell malignancies." in: PLoS ONE, Vol. 6, Issue 6, pp. e21018, 2011

Grumolato, Liu, Mong, Mudbhary, Biswas, Arroyave, Vijayakumar, Economides, Aaronson: "Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors." in: Genes & development, Vol. 24, Issue 22, pp. 2517-30, 2010

Images

Product Details anti-ROR1 Antibody Target Details ROR1 Application Details Handling References for anti-ROR1 Antibody (ABIN2659390) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-ROR1 antibody (Receptor Tyrosine Kinase-Like Orphan Receptor 1)  (PE-Cy7) (ABIN2659390) anti-Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) antibody (PE-Cy7)