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|Application / Reactivity||Human|
|ELISA (Capture)||1 Antibodies|
|Enzyme Immunoassay (EIA)||2 Antibodies|
|Flow Cytometry (FACS)||25 Antibodies|
|Immunocytochemistry (ICC)||2 Antibodies|
|Immunofluorescence (IF)||2 Antibodies|
|Immunohistochemistry (IHC)||45 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||8 Antibodies|
|Immunoprecipitation (IP)||5 Antibodies|
|Western Blotting (WB)||74 Antibodies|
|Antigen||Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2) Antibodies|
|Epitope||AA 19-50, N-Term Alternatives|
|Conjugate||This ROR2 antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|7 references available|
|Supplier||Log in to see|
Product Details anti-ROR2 AntibodyTarget Details ROR2 Application Details Handling References for anti-ROR2 Antibody (ABIN392044) Images
|Specificity||This ROR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27~57 amino acids from the N-terminal region of human ROR2.|
|Purification||This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Immunogen||This ROR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-50 AA from the N-terminal region of human ROR2.|
Target Details ROR2Product Details anti-ROR2 Antibody Application Details Handling References for anti-ROR2 Antibody (ABIN392044) Images back to top
|Alternative Name||ROR2 (ROR2 Antibody Abstract)|
ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1). BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS). RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.
Synonyms: Tyrosine-protein kinase transmembrane receptor ROR2, Neurotrophic tyrosine kinase, receptor-related 2 NTRKR2
|Molecular Weight||104726 Da|
|Research Area||Phospho-specific antibodies, Stem Cells, Cell Signaling, Protein Modifications, Cell Structure|
|Pathways||RTK Signaling, WNT Signaling|
Application DetailsProduct Details anti-ROR2 Antibody Target Details ROR2 Handling References for anti-ROR2 Antibody (ABIN392044) Images back to top
|Application Notes||WB = 1:1000, IHC (p) = 1:10-50, FACS = 1:10-50|
|Restrictions||For Research Use only|
HandlingProduct Details anti-ROR2 Antibody Target Details ROR2 Application Details References for anti-ROR2 Antibody (ABIN392044) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.|
|Expiry Date||6 months|
References for anti-ROR2 Antibody (ABIN392044)Product Details anti-ROR2 Antibody Target Details ROR2 Application Details Handling Images back to top
|Product cited in:||
Ma, Henry, Llamosas et al.: "Validation of specificity of antibodies for immunohistochemistry: the case of ROR2." in: Virchows Archiv : an international journal of pathology, 2016 (PubMed).
OConnell, Fiori, Xu et al.: "The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma." in: Oncogene, Vol. 29, Issue 1, pp. 34-44, 2010 (PubMed).
Schwabe, Tinschert, Buschow et al.: "Distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B." in: American journal of human genetics, Vol. 67, Issue 4, pp. 822-31, 2000 (PubMed).
van Bokhoven, Celli, Kayserili et al.: "Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome." in: Nature genetics, Vol. 25, Issue 4, pp. 423-6, 2000 (PubMed).
Afzal, Rajab, Fenske et al.: "Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2." in: Nature genetics, Vol. 25, Issue 4, pp. 419-22, 2000 (PubMed).
Oldridge, Fortuna, Maringa et al.: "Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B." in: Nature genetics, Vol. 24, Issue 3, pp. 275-8, 2000 (PubMed).
Masiakowski, Carroll: "A novel family of cell surface receptors with tyrosine kinase-like domain." in: The Journal of biological chemistry, Vol. 267, Issue 36, pp. 26181-90, 1993 (PubMed).
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