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|Application / Reactivity||Human|
|Enzyme Immunoassay (EIA)||3 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies|
|Immunofluorescence (IF)||1 Antibodies|
|Immunohistochemistry (IHC)||30 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||6 Antibodies|
|Western Blotting (WB)||85 Antibodies|
|Antigen||RYK Receptor-Like Tyrosine Kinase (RYK) Antibodies|
|Epitope||Middle Region Alternatives|
|Conjugate||This RYK antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|3 references available|
|Supplier||Log in to see|
Product Details anti-RYK AntibodyTarget Details RYK Application Details Handling References for anti-RYK Antibody (ABIN453358) Images
|Specificity||This antibody reacts to Tyrosine-protein kinase RYK.|
|Purification||Saturated Ammonium Sulfate (SAS) precipitation|
|Immunogen||KLH conjugated synthetic peptide selected from the Center region of human RYK|
Target Details RYKProduct Details anti-RYK Antibody Application Details Handling References for anti-RYK Antibody (ABIN453358) Images back to top
|Alternative Name||Tyrosine-Protein Kinase RYK (RYK Antibody Abstract)|
|Background||RYK is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. A nine nucleotide insertion in some transcripts results in the SLG variant. It is not established whether this is a product of alternative splicing or a second gene, since evidence for a second gene or pseudogene on chromosome 17 exists.Synonyms: JTK5A|
|Pathways||RTK Signaling, WNT Signaling|
Application DetailsProduct Details anti-RYK Antibody Target Details RYK Handling References for anti-RYK Antibody (ABIN453358) Images back to top
ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-RYK Antibody Target Details RYK Application Details References for anti-RYK Antibody (ABIN453358) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
References for anti-RYK Antibody (ABIN453358)Product Details anti-RYK Antibody Target Details RYK Application Details Handling Images back to top
Trivier, Ganesan: "RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6." in: The Journal of biological chemistry, Vol. 277, Issue 25, pp. 23037-43, 2002 (PubMed).
Katso, Russell, Ganesan: "Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase family." in: Molecular and cellular biology, Vol. 19, Issue 9, pp. 6427-40, 1999 (PubMed).
Wang, Katso, Butler et al.: "H-RYK, an unusual receptor kinase: isolation and analysis of expression in ovarian cancer." in: Molecular medicine (Cambridge, Mass.), Vol. 2, Issue 2, pp. 189-203, 1996 (PubMed).
ImagesProduct Details anti-RYK Antibody Target Details RYK Application Details Handling References for anti-RYK Antibody (ABIN453358) back to top