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RYK and VANGL2 (show VANGL2 Proteins) proteins form a complex, whereas RYK also activated RhoA (show RHOA Proteins), a downstream effector of PCP (show PRCP Proteins) signaling.
Data suggest that full-length Ryk conveys Wnt5b (show WNT5B Proteins) signals in a directional manner during gastrulation.
our findings demonstrate that Ryk promotes stem cell-like and tumorigenic features to glioma cells its essential for the maintenance of glioblastoma stem cells
Wnt5A (show WNT5A Proteins)/Ryk signaling might provide novel therapeutic strategies to prevent capillary leakage in systemic inflammation and septic shock.
results corroborated previous findings of Ryk-mediated Wnt5a (show WNT5A Proteins) effect, and suggested a role for Ror2 (show ROR2 Proteins) in the Wnt5a (show WNT5A Proteins) machinery in glioblastoma
Early treatment with HGF (show HGF Proteins)/IgG complexes after myocardial ischaemia with reperfusion may rescue tissue through vasoprotection conferred by c-Met and RYK signalling
Ryk-intracellular domain pathway may impair FOXO (show FOXO3 Proteins) protective activity in mutant polyglutamine neurons, suggesting neurons unable to efficiently maintain function and resist disease from the earliest phases of the pathogenic process in Huntington disease (show HTT Proteins)
is a candidate wnt5a (show WNT5A Proteins) receptor.
The Ryk is important for the Wnt-5a (show WNT5A Proteins)-dependent induction of MMP-2 (show MMP2 Proteins) and invasive activity in glioma-derived cells and that Ryk might have a novel patho-physiological function in adult cancer invasion.
RYK interacts both physically and functionally with the E3 ubiquitin MIB1. MIB1 is sufficient to activate Wnt (show WNT2 Proteins)/CTNNB1 (show CTNNB1 Proteins) signaling and this activity depends on endogenous RYK.
RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6.
reveal a novel function of Ryk signaling in controlling motor cortex remapping after spinal cord injury in adulthood.
Ryk deficiency in hematopoietic stem cells from fetal liver reduces their quiescence, leading to proliferation-induced apoptosis and decreased self-renewal.
Wnt5a (show WNT5A Proteins) regulates HSC (show FUT1 Proteins) quiescence and hematopoietic repopulation through the Ryk receptor and that this process is mediated by suppression of reactive oxygen species.
Ryk inhibits axonal growth in response to Wnt5a (show WNT5A Proteins).
Ryk is an important mediator of ventral midbrain dopaminergic neuron development.
Ryk regulates Wnt5a (show WNT5A Proteins) signaling and planar cell polarity by modulating the degradation of Vangl2 (show VANGL2 Proteins).
RYK and VANGL2 (show VANGL2 Proteins) proteins form a complex, whereas RYK also activated RhoA (show RHOA Proteins), a downstream effector of PCP (show BMP1 Proteins) signaling.
Results identify Ryk as a multi-functional receptor that is able to transduce extrinsic cues into progenitor cells, promote GABAergic neuron formation, and inhibit oligodendrogenesis during ventral embryonic brain development.
Mammalian Ryk, unlike the Drosophila Ryk homolog Derailed, functions as a coreceptor along with Frizzled for Wnt (show WNT2 Proteins) ligands.
The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
RYK receptor-like tyrosine kinase
, tyrosine kinase RYK
, ryk receptor-like tyrosine kinase
, receptor-like tyrosine kinase
, tyrosine-protein kinase RYK
, tyrosine kinase-related protein
, tyrosine-protein kinase RYK-like
, JTK5A protein tyrosine kinase
, hydroxyaryl-protein kinase
, growth factor receptor
, kinase VIK
, met-related kinase